刘润恒 | 中山大学附属口腔医院

刘润恒

副主任医师硕士生导师

导师简介

【学位/学历】

博士研究生 / 口腔临床医学博士

【学术简历】（注：时间正序写，从大学开始）

2009.09-2014.06 中山大学口腔医学专业获学士学位

2014.09-2019.06 中山大学口腔临床医学专业获博士学位（硕博连读）

【研究方向】

1. 口腔种植相关软硬组织再生

2. 精准种植

【主持课题】

1. 2025.07，上颌磨牙腭根即刻种植的前瞻性真实世界队列研究，企事业合作单位-临床研究，6万元

2. 2024.03，基于靶向调控巨噬细胞磷脂酰丝氨酸外翻的IL-4/EGTA-MSNs胶原膜涂层研发，广东省自然科学基金-面上项目，15万元

3. 2023.08，BAPTA-MSNs/IL4水凝胶涂层靶向调控巨噬细胞磷脂酰丝氨酸外翻强化胶原膜屏障功能的研究，国家自然科学基金-青年项目，30万元

4. 2022.12，通过靶向调控IL-13的聚多巴胺涂层调节屏障胶原膜降解性能的体内外及机制研究，广东省基础与应用基础研究基金委，区域联合基金青年基金项目，10万元

5. 2020.07，应用免疫调节策略实现屏障胶原膜的个性化降解调控，中国博士后科学基金会，面上资助，8万元

【发表论文】

1. Runheng Liu#, Shoucheng Chen#, Peina Huang, Guanqi Liu, Pu Luo, Zhipeng Li, Yin Xiao, Zhuofan Chen*, Zetao Chen*. Immunomodulation-based strategy for improving soft tissue and metal implant integration and its implications in the development of metal soft tissue materials. Advanced Functional Materials, 2020, 30, 21, 1910672.（实际第一作者，中科院大类1区，top期刊，IF=19.0）

2. Guanqi Liu#, Xiaoyan Chen, Jiahui Lin, Yuhan Hou, Runheng Liu*, Orchestrating Membranous Biomaterials Preservation: Multi-Pathway Immunomodulation of Macrophage Fusion and Membrane Stability via BAPTA-Loaded Mesoporous Silica Nanoparticles. Materials & Design, 2026, 263, 115644.（唯一通讯作者，中科院大类2区，IF=7.9）

3. Runheng Liu#, Ruidi Xia#, Linjun Zhang#, Xuejing Gan, Cuijun Li, Quan Liu, Zhuofan Chen, Zetao Chen*. The influence of guide stabilizers and their application sequences on trueness and precision of surgical guides in free end situations: An in vitro analysis. Clinical Oral Implants Research. 2024, 35, 3, 294-304.（实际第一作者，中科院大类1区，top期刊，IF=5.3）

4. Guanqi Liu#, Junda Li#, Xiaoyan Chen, Jiahui Lin, Runzhong Liu, Zhuofan Chen*, Runheng Liu*, AI-Based Evaluation of Implant Abutment Screw Torque Decay: A Periapical Radiograph Pilot Study, Journal of Periodontology. 2026.(Accepted)（最后通讯作者，中科院大类2区，top期刊，IF=3.8）

5. Guanqi Liu#, Yuanxiang Liu#, Yuhan Hou, Jiahui Lin, Xiaoyan Chen, Runheng Liu*, Immunological Features of Peri-Implant Soft Tissue After Healing Abutment Dislodgement: A Comparative Human Study. International Dental Journal, 2026.(Accepted)（唯一通讯作者，中科院大类2区，IF=3.7）

6. Guanqi Liu#, Jiahui Lin, Xiaoyan Chen, Runheng Liu*, Gingival Fibroblast Suppress the Osteogenesis Process Mediated by Bone Substitute Materials via WNT/β-catenin Signaling Pathway in vitro and in vivo. Frontiers in Bioengineering and Biotechnology, 2025, 13:1521134.（唯一通讯作者，中科院大类3区，IF=4.8）

7. Guanqi Liu#, Shudan Deng#, Jiahui Lin, Xiaoyan Chen, Runheng Liu*, Biomechanical analysis of maxillary posterior three unit bridge supported misial straight implant and distal tilted implant. Frontiers in Bioengineering and Biotechnology. 2025, 13:1546656.（唯一通讯作者，中科院大类3区，IF=4.8）

8. Guanqi Liu#, Shudan Deng#, Runzhong Liu, Yuanxiang Liu, Quan Liu, Shiyu Wu, Zhuofan Chen*, Runheng Liu*, Precise multi-factor immediate implant placement decision models based on machine learning. Scientific Reports. 2025, 15:5143.（唯一通讯作者，中科院大类3区，IF=3.9）

9. Runheng Liu#, Jiahui Lin, Xiaoyan Chen, Yuhan Hou, Guanqi Liu*, Yan Wang*, From Challenge to Competence: The Role of Learning Engagement in Mediating Stress and Performance Among Clinical Medical Students in English-Medium Dental Education. Frontiers in Medicine. 2025, 12:1675855.（唯一第一作者，中科院大类3区，IF=3.0）

10. Runheng Liu#, Yixiong Lin#, Jinying Lin#, Linjun Zhang, Xueli Mao, Baoxin Huang, Yin Xiao*, Zhuofan Chen*, Zetao Chen*, Blood Prefabrication Subcutaneous Small Animal Model for the Evaluation of Bone Substitute Materials, ACS Biomaterials Science & Engineering, 2018, 4, 7, 2516–2527.（实际第一作者，中科院大类3区，IF=5.5）

11. Runheng Liu#, Wei Qiao#, Baoxin Huang, Zetao Chen, Jinghan Fang, Zhipeng Li*, Zhuofan Chen*, Fluorination enhances osteogenic capacity of porcine hydroxyapatite, Tissue Engineering Part A, 2018, 24, 15-16, 1207-1217.（实际第一作者，中科院大类3区，IF=2.9）

12. Guanqi Liu#, Runheng Liu*. Maxillary Immediate Molar Implant Placement into Palatal Root Socket: A Case Report of 2 Year Follow Up. Cureus Journal of Medical Science, 2024,9;16(10):e71152.（唯一通讯作者，中科院大类4区，IF=1.3）

13. Jinghan Fang#, Runheng Liu#, Shoucheng Chen, Quan Liu, Huaxiong Cai, Yixiong Lin, Zetao Chen*, Zhuofan Chen*, Tuning the immune reaction to manipulate the cell-mediated degradation of a collagen barrier membrane, Acta Biomaterialia, 2020, 109, 95-108.（共同第一作者，中科院大类1区，top期刊，IF=9.6）

14. Xiongjun Xu#, Junming Feng#, Tianze Lin, Runheng Liu*, Zhuofan Chen*. miR-181a/MSC-Loaded Nano-Hydroxyapatite/Collagen Accelerated Bone Defect Repair in Rats by Targeting Ferroptosis Pathway. Journal of Functional Biomaterials, 2024, 15(12), 385.（共同通讯作者，中科院大类3区，IF=5.2）

15. Wei Qiao#, Runheng Liu#, Zhipeng Li, Xin Luo, Baoxin Huang, Kelvin W.K. Yeung, James Tsoi, Richard Yu Xiong Su, Jukka Matinlinna, Zhuofan Chen*, Contribution of the in situ release of endogenous cations from xenograft bone driven by fluoride incorporation toward enhanced bone regeneration, Biomaterials Science, 2018, 6, 2951-2964.（共同第一作者，中科院大类3区，IF=5.7）

16. Zetao Chen#, Lingling Chen#, Runheng Liu#, Yixiong Lin, Shoucheng Chen, Shifeier Lu, Zhengmei Lin, Zhuofan Chen*, Chengtie Wu*, Yin Xiao*, The osteoimmunomodulatory property of barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration, Biomaterials Science, 2018, 6, 1007-1019.（共同第一作者，中科院大类3区，IF=5.7）

17. Shoucheng Chen#, Yuanlong Guo#, Runheng Liu#, Shiyu Wu, Jinghan Fang, Baoxin Huang, Zhipeng Li, Zhuofan Chen*, Zetao Chen*, Tuning surface properties of bone biomaterials to manipulate osteoblastic cell adhesion and the downstream signaling pathways for the enhancement of early osseointegration, Colloids and Surfaces B: Biointerfaces, 2018, 164, 58-69. （共同第一作者，中科院大类2区，IF=5.6）

18. 刘润恒#, 刘于冬, 陈卓凡*. 微小RNA在骨分化过程中的作用机制[J]. 国际口腔医学杂志, 2017, 44(1):108-113.（唯一第一作者）

19. 刘润恒*. 中切牙冠折不翻瓣即刻种植即刻修复联合结缔组织移植1例附3年随访. 中国临床案例成果数据库, 2025,07(01): E2306-E2306.（唯一通讯作者）

20. 刘远翔#, 刘润恒*.单颗种植体支持两单位单端固定桥修复的研究进展. 临床口腔医学杂志，2026, 42.（已接收）（唯一通讯作者）