陈冬茹 | 中山大学附属口腔医院

陈冬茹

副主任医师硕士生导师

导师简介

【学位/学历】

博士研究生 / 口腔临床医学博士

【学术简历】

2009.09-2014.06 中山大学口腔医学专业获学士学位

2014.07-2016.06 中山大学口腔医学专业获硕士学位

2016.09-2019.06 中山大学口腔临床医学专业获博士学位

【研究方向】

1.龋病

2.细菌生物膜

3.抗菌药物

【主持课题】

1. 2024-10至2026-10，不同含氟浓度牙膏对固定矫治青少年的口腔菌群微生态及龋病影响的前瞻性研究, 中华口腔医学会青年临床科研基金, 5万元

2. 2023-01至2025-12，新型抗生物膜形成的淀粉样六肽聚合机制及构效关系解析，国家自然科学基金委员会青年项目，30万元

3. 2020.01-2021.09，变异链球菌淀粉样纤维的聚合机理及关键聚合位点研究，中国博士后科学基金第68批面上一等资助，12万元

4. 2020-01至2022-12，淀粉样蛋白C123选择性抗革兰氏阳性菌的作用机制及其效能优化，广东省基础与应用基础研究基金区域联合基金—青年基金项目，10万元

5. 2020-01至2022-12，变异链球菌来源淀粉样多肽AgII选择性抗革兰氏阳性菌的机制研究，高校基本科研业务费中山大学青年教师培育项目，5万元

【发表论文】

(1) 陈冬茹. 骨性II类下颌后缩的双期矫治病例1例. 中国临床案例成果数据库. 2025.8.14. Doi:10.3760/cma.j.cmcr20250728-03157

(2) Chen Dongru#, Liu Xiangqi#, Liu Yuanbo, Wang Xi, Zheng Jinxuan, Wu Liping*. Virtual reality used in undergraduate orthodontic education. European Journal of Dental Education. ISSN:1396-5883, [J]. 2023,;00:1-9. doi:10.1111/eje.12968.

(3) Huang Yiyi#, Wang Tingyu#, Chen Yucong, Lin Huancai*, Chen Dongru*. Amyloid hexapeptide prevent dental caries by antibiofilm formation. Journal of Dentistry, 2023.6.22. https://doi.org/10.1016/j.jdent.2023.104596

(4) Chen Dongru#, Wang Tingyu#, Huang Yiyi, Chen Yucong, Lin Huancai*, Wu Liping*. The morphology and structural features of self-aggregating hexapeptides with antibiofilm formation activity. Materials Advances, 2023,4,4110-4118，DOI: 10.1039/d3ma00014a

(5) Chen Dongru#; Liu Xiangqi#; Chen Yucong; Lin Huancai*; Amyloid peptides with antimicrobial and/or microbial agglutination activity. Applied Microbiology and Biotechnology, 2022 Dec;106(23):7711-7720. Doi: 10.1007/s00253-022-12246-w.

(6) 陈冬茹，林焕彩. 变异链球菌致龋机制研究新进展. 四川大学学报（医学版）， 2022，53(2):208-213

(7) Chen Dongru#; Li Jing#; Pan Ting; Wu Ruixue; Tao Ye; Lin Huancai*; The broad-spectrum antibiofilm activity of amyloidforming hexapeptides. Microbial Biotechnology, 2021 Mar; 14(2): 656–667, doi: 10.1111/1751-7915.13721. (IF=5.813)

(8) Li Jing#; Chen Dongru#; Lin Huancai*; Antibiofilm peptides as a promising strategy: comparative research. Applied Microbiology and Biotechnology, 2021 Feb;105(4):1647-1656, doi: 10.1007/s00253-021-11103-6. (IF=4.813)

(9) Chen Yuanyuan; Cui Guxin; Cui Yuqi; Chen Dongru*; Lin Huancai*; Small molecule targeting amyloid fibrils inhibits Streptococcus mutans biofilm formation. AMB Express, 2021. 11(1): p. 171, doi: 10.1186/s13568-021-01333-2. (IF=3.298)

(10) Chen Dongru; Cao Yina; Yu Lixia; Tao Ye; Zhou Yan; Zhi Qinghui; Lin Huancai*; Characteristics and influencing factors of amyloid fibers in S.mutans biofilm. AMB Express, 2019, 9(1): 31-39. (IF=3.298)

(11) Chen Dongru; Zhi Qinghui; Zhou Yan; Tao Ye; Wu Liping*; Lin Huancai*; Association between Dental Caries and BMI in Children: A Systematic Review and Meta-Analysis. Caries Research, 2018, 52(3): 230-245.

(12) Chen, Dongru; Wu, Liping*; Liu, Lu; Gong, Qimei; Zheng, Jinxuan; Peng, Caixia; Deng, Jianqing; Comparison of HIF1A-AS1 and HIF1A-AS2 in regulating HIF-1 alpha and the osteogenic differentiation of PDLCs under hypoxia , International Journal of Molecular Medicine, 2017, 40(5): 1529-1536.

(13) Zhang, Xueqin#; Chen, Dongru#; Zheng, Jinxuan; Deng, Lidi; Chen, Zhengyuan; Ling, Junqi*; Wu, Liping*; Effect of microRNA-21 on hypoxia-inducible factor-1α in orthodontic tooth movement and human periodontal ligament cells under hypoxia , Experimental and Therapeutic Medicine, 2019, 17(4): 2830-2836.

(14) Liu, Xiangqi#; Chen, Dongru#; Lao, Xiaomei*; Liang, Yujie*; The value of MYB as a prognostic marker for adenoid cystic carcinoma: Meta-analysis, Head and Neck-Journal for the Sciences and Specialties of the Head and Neck, 2019, 4 1(5): 1517-1524.

(15) 陈冬茹，吴莉萍. 低氧诱导因子-1α和反义低氧诱导因子-1α的研究进展. 国际口腔医学杂志, 2016. 43(05): 589-593.

其它作者

(1) Yuqi Cui, Dongru Chen, Huancai Lin, Ye Tao; The association between low birth weight and/or preterm birth and dental caries -A systematic review and meta-analysis. Int J Dent Hyg. 2022 Dec 15.

(2) Yin L, Zhu W, Chen D, et al. Small noncoding RNA sRNA0426 is involved in regulating biofilm formation in Streptococcus mutans[J]. Microbiologyopen, 2020,9(9):e1096.

(3) Cao Y, Zhou Y, Chen D, et al. Proteomic and metabolic characterization of membrane vesicles derived from Streptococcus mutans at different pH values[J]. Appl Microbiol Biotechnol, 2020,104(22):9733-9748.

(4) Chen Z, Zheng J, Hong H, Chen D, et al. lncRNA HOTAIRM1 promotes osteogenesis of hDFSCs by epigenetically regulating HOXA2 via DNMT1 in vitro[J]. J Cell Physiol, 2020,235(11):8507-8519.

(5) Chen Y, Chen D, Lin H. Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis[J]. BMC Oral Health, 2021,21(1):13.

(6) 艾婷婷，郑金绚，陈冬茹，等. CBL联合TBL教学法同步培养口腔正畸专业研究生临床和科研能力的效果研究[J]. 中华口腔医学研究杂志(电子版), 2021,15(02):114-118.

(7) Zhou Y, Chen DR, Zhi QH, Tao Y, Wang X, Feng XP, Tai B, Hu Y, Wang B, Wang C, Zheng S, Liu X, Rong W, Wang W, Si Y, Lin H*. The Prevalence and Associated Risk Indicators of Dental Fluorosis in China: Findings from the 4th National Oral Health Survey. Chin J Dent Res. 2018;21(3):205-11.

(8) Peng C, Zheng J, Chen D, Zhang X, Deng L, Chen Z, Wu L*. Response of hPDLSCs on 3D printed PCL/PLGA composite scaffolds in vitro. Mol Med Rep. 2018;18(2):1335-44.

(9) Deng L, Hong H, Zhang X, Chen D, Chen Z, Ling J*, Wu L*. Down-regulated lncRNA MEG3 promotes osteogenic differentiation of human dental follicle stem cells by epigenetically regulating Wnt pathway. Biochem Biophys Res Commun. 2018;503(3):2061-7.

(10) 邓建清，卢新华，彭彩霞，陈冬茹，吴莉萍*.安氏Ⅱ类1分类错(牙合)正畸治疗前后前牙区牙槽骨高度改变的CBCT研究. 中华口腔正畸杂志. 2018(03）