王艺羲 | 中山大学附属口腔医院

王艺羲

副主任医师硕士生导师

导师简介

【学位/学历】

博士/博士研究生

【学术简历】

2009.09-2014.06 中山大学口腔医学专业获学士学位

2014.07-2016.06 中山大学口腔临床医学（七年制）专业获硕士学位

2016.09-2019.06 中山大学口腔临床医学专业获博士学位

【研究方向】

1.口腔疾病与中枢神经系统及其他全身系统性疾病的关系研究

2.口腔正畸学

【主持课题】

1. 2021.01-2023.12：《口腔牙龈卟啉单胞菌感染通过促进神经元铁死亡损害学习记忆功能的分子机制》，国家自然科学基金-青年项目，24万

2. 2020.07-2021.11：《神经元铁死亡介导口腔Pg感染损害学习记忆功能的分子机制》，中国博士后科学基金面上项目，10万

【发表论文】

（格式：1.全部作者，论文题目，发表杂志，年卷页（作者要求：本人加粗、共一的加#、共同通讯的加*））

1. Yixi Wang, Zhuokai Wu, Yiheng Zheng, Haimeng Wang, Bin Cheng, Juan Xia. Unraveling the genetic underpinnings of mitochondrial traits and associated circulating inflammatory proteins in Alzheimer’s disease: mitochondrial HtrA2-T cell CD5 negative axis. Journal of Alzheimer’s Disease. 2025 May;105(2):505-518.

2. Zhuokai Wu#, Chixing Cheng#, Zhaoxin Li, Minyi Ren, Hongxi Cao, Weijie Huang, Jun Wang, Lixian Wu, Tingyi Lee, Sien Zhang*, Hanhao Zheng*, Yixi Wang*. Comprehensive tumour-immune profiling reveals TREM2+ tumour-associated macrophages facilitating lymph node metastasis in head and neck squamous cell carcinoma. Clinical and Translational Medicine. 2026;16:e70604.

3. Wang Yixi, Kang Xiaoning, Cao Yang, Zheng Dexiu, Lu Yeming, Pang Chunfeng, Wang Zhi, Cheng Bin, Peng Yun. Porphyromonas gingivalis induces depression via downregulating p75NTR-mediated BDNF maturation in astrocytes, Brain, Behavior, and Immunity, 2019, 81: 523-534.

4. Yixi Wang*, Haimeng Wang, Bin Cheng, Juan Xia*. Associations between triglyceride glucose index-related obesity indices and anxiety: Insights from the National Health and Nutrition Examination Survey 2007-2012. Journal of Affective Disorders. 2025 Aug 1:382:443-452.

5. Tieshi Zhu#, Yong He#, Yixi Wang*, Le Zhao*. GrimAge and GrimAge2 Age Acceleration Effectively Predict Mortality Risk: A Retrospective Cohort Study. Epigenetics.2025 20:1, 2530618.

6. Yixi Wang#, Na Zhao#, Xianwen Zhang#, Zhenhua Li, Zheng Liang, Jinrong Yang, Xingyu Liu, Yangzhe Wu, Kebing Chen, Yunfei Gao, Zhinan Yin, Dongbo Tian*, Yang Cao*, Jianlei Hao*. Bibliometric analysis of butyrophilins as immune regulators [1992-2019] and implications for cancer prognosis. Front. Immunol, 2020, 11:01187.

7. Dexiu Zheng, Xiaoning Kang, Yixi Wang, Yina Huang; Chunfeng Pang, Yuxuan Chen, Zhili Kuang, Yun Peng. Periodontal disease and emotional disorders: A meta-analysis, Journal of Clinical Periodontology, 2020, 48(2): 180-204.