贾筱诗 | 中山大学附属口腔医院

贾筱诗

副主任医师硕士生导师

导师简介

【学位/学历】

博士研究生 / 口腔临床医学博士

【学术简历】（注：时间正序写，从大学开始）

2007.09-2012.07 郑州大学口腔医学专业获学士学位

2012.09-2014.06 郑州大学口腔医学专业获硕士学位

2015.09-2018.06 武汉大学口腔临床医学专业获博士学位

【研究方向】

1. 颌面部软、硬组织缺损修复

2. 颞下颌骨关节炎发病机制探索

3. 牙周及种植体周疾病修复策略

【主持课题】

（格式：1.年月，课题名称，项目名称，金额）

1. 2020/01-2022/12，Setd7通过诱导软骨细胞凋亡同时促进成骨分化诱发颞下颌关节骨关节病的机制研究，国家自然科学基金青年项目（编号：81901025），20万元。

2. 2019/10-2022.09，Setd7通过调控软骨内氧分压并介导软骨细胞凋亡诱发颞下颌关节骨关节病的机制研究，广东省自然科学基金面上项目（编号：2019A1515011326），10万元。

3. 2019/05-2021/05，Setd7调控关节软骨内氧分压及软骨细胞凋亡的机制研究，中国博士后科学基金第65批面上资助（编号：2019M653232），8万元。

4. 2019/01-2021/12，Setd7调控高氧分压下软骨细胞凋亡和分化的机制研究，高校基本科研业务费中山大学青年教师培育项目（编号：19ykpy82），15万元。

5. 2022/04-2024/03，PCL/SF/CHA支架调控M2型巨噬细胞极化促进衰老相关骨质疏松骨缺损修复的机制研究，广州市科技计划一般项目（博士青年科技人员类）（编号：202201010992），5万元。

【发表论文】

[1] Yan YN^#, Yan QQ^#, Cai KX^#, Wang ZH, Li QL, Zhao K*, Jian YT*, Jia XS*. Silk fibroin microgrooved zirconia surfaces improve connective tissue sealing through mediating glycolysis of fibroblasts. Material Today Bio. 2024,14;27:101158. doi: 10.1016/j.mtbio.2024.101158.

[2] Wang ZH^#, Tuerxun P^#, Ng T^#, Yan YN, Zhao K*, Jian YT*, Jia XS*. Enhancing angiogenesis in peri-implant soft tissue with bioactive silk fibroin microgroove coatings on zirconia surfaces. Regenerative Biomaterials. 2024,17;11:rbae068. doi: 10.1093/rb/rbae068.

[3] Jia XS^#, Zhou J^#, Ning JQ^#, Li MQ, Yao YT, Wang XD*, Jian YT*, Zhao K*. The polycaprolactone/silk fibroin/carbonate hydroxyapatite electrospun scaffold promotes bone reconstruction by regulating the polarization of macrophages. Regenerative Biomaterials. 2022,11;9:rbac035.

[4] Li MQ^#, Ning JQ^#, Wang JW, Yan QQ, Zhao K*, Jia XS*. SETD7 regulates chondrocyte differentiation and glycolysis via the Hippo signaling pathway and HIF‑1α. International Journal of Molecular Medicine. 2021, 48(6): 210.

[5]Jia XS^#, Li MQ, Wang JW, Ning JQ, Zhao K*. SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthritis. FASEB J. 2021;35: e21283.

[6] Jia XS^#, Long QY, R.J. Miron, Yin CC, Wei Y, Zhang YF*, Wu M*. Setd2 is associated with strontium-induced bone regeneration. Acta Biomaterialia, 2017, 53:495-505.

[7] Jia XS^#, R.J. Miron, Yin CC, Xu HD, Luo T, Wang JW, Jia R, Wu M, Zhang YF, Li YH*. HnRNPL inhibits the osteogenic differentiation of PDLCs stimulated by SrCl₂ through repressing Setd2. J Cell Mol Med, 2019, doi: 10.1111/jcmm.14166.

[8] Jia XS^#, Xu HD^#, R.J. Miron, Yin CC, Zhang XX, Wu M*, Zhang YF*, EZH1 Is Associated with TCP-Induced Bone Regeneration through Macrophage Polarization, Stem Cells International, 2018, doi: 10.1155/2018/6310560.

[9] Wang JW^#, Chen JM, Zhang B, Jia XS*. IL-6 regulates the bone metabolism and inflammatory microenvironment in aging mice by inhibiting Setd7. Acta Histochem. 2021, 123(5):151718.

[10] Yao YT^#, Jia XS^#, Chen SM^#, Zhong J, Wang XD, Gong QM*, Jian Y*, Zhao K*. Extensive cell seeding densities adaptable SF/PGA electrospinning scaffolds for bone tissue engineering. Biomater Adv. 2022,137:212834.

[11] Qi Q^#, Yao YT^#, Jia XS^#, Meng Y*, Zhao K*, Jian YT*. Effects of polyethylene glycol content on the properties of a silk fibroin/nano-hydroxyapatite/polyethylene glycol electrospun scaffold. RSC Adv. 2019,22;9(58):33941-33948.

[12] Jia XS, Guo JW, Wu MD, Wang XD, Fan L, Yao YC, Deng XY, Yang L. Study on the effect of simulation-based case teaching method on the preclinical teaching of tooth defects restoration. BMC Medical Education. 2025, 25(1):487.

[13] Tuerxun P^#, Ng TK^#, Sun JD, Ou FR, Jia XS*, Zhao K*, Zhu P*. Lipoxin A4 modulates the PKA/CREB and NF-κB signaling pathway to mitigate chondrocyte catabolism and apoptosis in temporomandibular joint osteoarthritis. Exp Cell Res. 2024;442(2):114249.

[14] Yin CC, Jia XS, Miron RJ, Long QY, Xu HD, Wei Y, Wu M*, Zhang YF*, Li ZB*. Setd7 and its contribution to Boron-induced bone regeneration in Boron-mesoporous bioactive glass scaffolds. Acta Biomater. 2018;73:522-530.

[15] Zhang JL^#, Wu Q^#, Yin CC, Jia XS, Zhao ZF, Zhang XX, Yuan GH, Hu H*, Zhao Q*. Sustained calcium ion release from bioceramics promotes CaSR-mediated M2 macrophage polarization for osteoinduction. J Leukoc Biol. 2021;110(3):485-496.

[16] Jiang X^#, Jian YT^#, Zhang Y^#, Zhong J, Li QL, Wang XD, Jia XS, Wu XN, Zhao K*, Yao YT*. Dual-Mode Release of IL-4 and TCP from a PGA-SF Core-Shell Electrospinning Scaffold for Enhanced Bone Regeneration through Synergistic Immunoregulation and Osteogenesis. ACS Appl Mater Interfaces. 2024;16(43): 58148-58167.

[17] Zhang Y^#, Jian YT^#, Jiang X^#, Li XR, Wu XN, Zhong J, Jia XS, Li QL, Wang XD*, Zhao K*, Yao YT*. Stepwise degradable PGA-SF core-shell electrospinning scaffold with superior tenacity in wetting regime for promoting bone regeneration. Mater Today Bio. 2024;26:101023.

[18] Zhao ZF, Dai J, Yin CC, Wang XZ, Wang JY, Jia XS, Zhao Q, Fu H, Zhang YF*, Xia HB*. Transcription factor 7-like 2-associated signaling mechanism in regulating cementum generation by the NF-κB pathway. J Cell Physiol. 2019;234(11): 20790-20800.