【学位/学历】

博士 / 博士研究生

【学术简历】

2008.09-2013.06  中山大学口腔医学专业获学士学位

2013.09-2016.06  中山大学遗传学专业获硕士学位

2016.09-2019.06  中山大学口腔临床医学专业获博士学位

【研究方向】

1.口腔遗传病（先天缺牙、唇腭裂、釉质发育不全等）的机制研究

2.牙外伤的治疗及预后研究

【主持课题】

   1.2021-2024年：DLX3通过ENAM调控釉质发育的机制研究及釉质发育不全突变数据库的构建，广东省基础与应用基础研究基金，10万

   2.2020-2021年：DLX3基因突变引起毛发-牙-骨综合征的机制及利用光遗传学治疗的研究，中国博士后科学基金，8万

【发表论文】

1. Lu H, Shi F, Wang B, Zheng Y, Lu J, Zeng B*, Zhao W*. Molecular Biological Comparison of Pulp Stem Cells from Supernumerary Teeth, Permanent Teeth, and Deciduous Teeth for Endodontic Regeneration. INT J MOL SCI 26, (2025)

2. He Y, Tang Y, Zeng B, Chen X, Yuan L, Lu Y, Du W, Li R, Han Y, Deng F, Yu D, Zhao W. Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation. Mater Today Bio. 2024;27:101122

 3. Li P#, Zeng B#, Xie W, Xiao X, Lin L, Yu D, Zhao W. Enamel Structure Defects in Kdf1 Missense Mutation Knock-in Mice. Biomedicines. 2023;11.

 4. Xie W, Zeng B, Li P, Xu D, Yu D, Zhao W. Two Novel Mutations in Ectodysplasin-A Identified in Syndromic Tooth Agenesis. J Coll Physicians Surg Pak. 2022;32: 570-574.

 5. Zhang W#, Zeng B#, Lin H, Guan W, Mo J, Wu S, Wei Y, Zhang Q, Yu D, Li W, Chan GC. CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects. Oncoimmunology. 2021;10(1):1944553.

 6. Zhang W#, Zeng B#, Yang M, Yang H, Wang J, Deng Y, Zhang H, Yao G, Wu S, Li W. ncRNAVar: A Manually Curated Database for Identification of Noncoding RNA Variants Associated with Human Diseases. J Mol Biol. 2021;433(11):166727.

 7. Zeng B#, Li Y#, Jiang F, Wei C, Chen G, Zhang W, Zhao W, Yu D. LncRNA GAS5 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition in oral squamous cell carcinoma by regulating the miR-21/PTEN axis. Experimental cell research. 2019;374(2):365-373.

 8. Zeng B#, Liao J#, Zhang H#, Fu S, Chen W, Pan G, Li Q, Chen W, Ferrone S, Wu B, Sun S, Hu J, Ahn MH, Lin Z, Yu D, Ou Z, Wang X, Mo F, Huang N, Hamilton JA, Li J, Fan S. Novel ANO5 mutation c.1067G>T (p.C356F) identified by whole genome sequencing in a big family with atypical gnathodiaphyseal dysplasia. Head Neck. 2019;41(1):230-238.

 9. Zeng B#, Lu H#, Xiao X, Yu X, Li S, Zhu L, Yu D, Zhao W. KDF1 is a novel candidate gene of non-syndromic tooth agenesis. Archives of oral biology. 2019;97:131-136.

 10. Zeng B#, Zhao Q#, Li S, Lu H, Lu J, Ma L, Zhao W, Yu D. Novel EDA or EDAR Mutations Identified in Patients with X-Linked Hypohidrotic Ectodermal Dysplasia or Non-Syndromic Tooth Agenesis. Genes (Basel). 2017;8(10).

 11. Zeng B#, Xiao X#, Li S, Lu H, Lu J, Zhu L, Yu D, Zhao W. Eight Mutations of Three Genes (EDA, EDAR, and WNT10A) Identified in Seven Hypohidrotic Ectodermal Dysplasia Patients. Genes (Basel). 2016;7(9).

 12. Zeng B#, Lu H#, Xiao X, Zhou L, Lu J, Zhu L, Yu D, Zhao W. Novel EDA mutation in X-linked hypohidrotic ectodermal dysplasia and genotype-phenotype correlation. Oral Dis. 2015;21(8):994-1000.

 13. Zeng B, Li R, Hu Y, Hu B, Zhao Q, Liu H, Yuan P, Wang Y. A novel mutation and a known mutation in the CLCN7 gene associated with relatively stable infantile malignant osteopetrosis in a Chinese patient. Gene. 2016;576(1 Pt 1):176-81.

 14. Lin B#, Zeng B# , Zhao J, Xu T, Wang Y, Hu B, Li F, Zhao Q, Liu R, Liu J, Chen J, Huang D, Wang Y. Seven novel and three known mutations in FOXL2 in 10 Chinese families with Blepharophimosis syndrome. Current molecular medicine. 2018;3(18):152-159.

 15. Zou Z, Lu H, Zhang W, Li Y, He Y, Lin H, Zhao W, Yu D*, Zeng B*. Association of miR-155 and MIR155HG polymorphisms with cancer risk: A meta-analysis. J Cancer Res Ther. 2021;17: 1209-1218.

 16. 曾秉辉, 余东升. 口腔急诊科规范化建设的探讨. 中国口腔医学继续教育杂志. 2023;26(5):341-344.

 17. 曾秉辉, 余东升. 环状RNA研究进展及其在口腔疾病中的研究展望. 口腔疾病防治. 2017(02):123-128.

【社会兼职】

1. 广东省口腔医学会口腔急诊专业委员会常务委员

2. 中华口腔医学会口腔急诊专业委员会青年委员

【联系方式】

地址：广州市陵园路56号中山大学附属口腔医院急诊综合科

邮箱：zengbh8@mail.sysu.edu.cn