王彦 | 中山大学附属口腔医院

王彦

研究员博士生导师硕士生导师

导师简介

【学位/学历】

博士研究生 / 口腔临床医学博士

【学术简历】（注：时间正序写，从大学开始）

1996.04-2000.03 日本德岛大学口腔临床医学专业获博士学位

2000.06-2005.06 美国宾夕法尼亚大学、病毒学、博士后

2005.07-2010.02 美国宾夕法尼亚大学、病毒学、助理研究员

2010.2至今中山大学附属口腔医院、口腔基础医学、研究员/博导

【研究方向】

1. 间充质干细胞及其胞外囊泡在组织再生与疾病治疗中的应用

2. 间充质干细胞衰老机制的研究

3. 人类肿瘤病毒（KSHV、EBV）的致瘤分子机制

【主持课题】

2023-2026，牙周膜干细胞线粒体移植通过TOB2/SMAD5/PKM2赋能通路调控牙周骨稳态的机制研究，国家自然科学基金面上项目，55万

2021-2024，牙周膜干细胞外泌体miR-92a-3p通过Mfn1/ROS/HIF1α/LDHA通路调节巨噬细胞代谢和破骨分化，国家自然科学基金面上项目，55万

2016-2021，KSHV持续性感染口腔间充质干细胞与相关肿瘤发生的机制研究，国家自然科学基金重点项目（负责完成课题），327.6万

2014-2017，K8 在KSHV 流产性裂解复制中的作用及流产性裂解复制机制的研究，国家自然科学基金面上项目，70万

2012-2015，以宿主蛋白为靶点的新型抗卡波西式肉瘤相关病毒(KSHV)药物的基础研究，国家自然科学基金面上项目，58万

2010-2015，重大人类致病病毒特异性药物的研发与免疫细胞的再生工程（子项目），广东省科学技术厅广东省引进创新科研团队，100万

【发表论文】

近年发表论文

1. Shuqing Yang^# , Ming Zhang ^# , Junbin Wei ^# , Shuxuan Rong , Lingling Chen , Houze Li , Tingting Zhao, Junkun Zhan , Xiaoxiao Wang * , Yunyi Xie * and Yan Wang *. Transplantation of AQP1-overexpressing Mitochondria Attenuates Periodontitis-associated Bone Loss by Regulating Mitochondria-ER Contacts of Macrophages.Journal of Nanobiotechnology. Aceepted

2. Shuyuan Song ^# , Zhentao Lao^# , Ruotong Yu , Shan Yu , Peiyao Li, Yumeng Yan, Le Yang, Guiqing Liao* , Yan Wang *, Sien Zhang*. Immunotherapy-induced Sialadenitis: Sjögren’s syndrome or a New Sialadenitis.Frontiers in Immunology. 2026,17:1755419

3. Chuanmiao Lin，Junbin Wei，Tingting Zhao1，Lingling Chen，Shuxuan Rong，Junkun Zhan，Wenjia Lai，Yan Wang*，Yunyi Xie*，Huan Chen*. Klotho protects the osteogenic function of human periodontal ligament stem cells in periodontitis by inhibiting NOX4-mediated ferroptosis.Stem Cell Research&Therapy. 2026 Jan 16;17(1):81.

4. Yingying Peng, Tingting Zhao, Shuxuan Rong, Shuqing Yang ,Wei Teng*,Yunyi Xie* and Yan Wang*. Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics. Journal of Nanobiotechnology.2024;22(1):543

5. Niu Q^#, Lin C^#, Yang S, Rong S, Wei J, Zhao T, Peng Y, Cheng Z, Xie Y*, Wang Y*. FoxO1-Overexpressed Small Extracellular Vesicles Derived from hPDLSCs Promote Periodontal Tissue Regeneration by Reducing Mitochondrial Dysfunction to Regulate Osteogenesis and Inflammation. Int J Nanomedicine.International Journal of Nanomedicine 2024;19:8751-8768

6. Lu ZZ, Sun C, Zhang X, Peng Y, Wang Y, Zeng Y, Zhu N, Yuan Y, Zeng MS. Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis.Sci Adv2023;9(21):eadg1778.

7. Qingru Niu^#，Huan Chen^#, Qianmin Ou, Shuqing Yang, Yingying Peng, Yunyi Xie, Le Yu, Zhilan Cheng, Yang Cao*, Yan Wang*. Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy. J Orthop Surg Res. 2023;18(1):400

8. Yunyi Xie^#, Le Yu^#, Zhilan Cheng^#, Yingying Peng, Zeyuan Cao, Beichen Chen, Yihong Duan, Yan Wang*. SHED-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy. Journal of Nanobiotechnology. 2022;20(1):239.

9. Nannan Zhu, Qian Wang, Zhidong Wu, Yan Wang, Mu-Sheng Zeng, and Yan Yuan .EBV LMP1-activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties. J Virol. 2022;96(5):e0194121.

10. Qianmin Ou^#, Shaohan Zhang^#, Chuanqiang Fu, Le Yu, Peikun Xin, Zhipeng Gu,Zeyuan Cao, Jun Wu*, Yan Wang*. More natural more better: triple natural anti.oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing. Journal of Nanobiotechnology. 2021;19(1):237.

11. Lingping Tan^#, Zeyuan Cao^#, Huan Chen, Yunyi Xie, Le Yu, Chuanqiang Fu, Wei Zhao* and Yan Wang*. Curcumin reduces apoptosis and promotes osteogenesis of human periodontal ligament stem cells under oxidative stress in vitro and in vivo. Life Sciences. 2021;270 :119125.

12. Jiayuan Hu, Yan Wang, Yan Yuan. Inhibitors of APE1 redox function effectively inhibit γ-herpesvirusreplication in vitro and in vivo. Antiviral Research. 2021;185:104985.

13. Nannan Zhu, Xiaoting Xu, Yan Wang, Mu-Sheng Zeng, Yan Yun. EBV latent membrane proteins promote hybrid epithelial-mesenchymal and extreme mesenchymal states of nasopharyngeal carcinoma cells for tumorigenicity. PLOS Pathogens.2021;17(8):e1009873.

14. Yao Ding, Weikang Chen, Zhengzhou Lu,Yan Wang, Yan Yuan.Kaposi's Sarcoma-associated Herpesvirus Promotes Mesenchymal-to-Endothelial Transition by Resolving the Bivalent Chromatin of PROX1 Gene. PLOS Pathogens, PLoS Pathog. 2021;17(9):e1009847.

15. Weikang Chen,Yao Ding, Zhengzhou Lu, Yan Wang, Yan Yun. Kaposi’s sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis.PLoS Pathog. 2021;17(12): e1009600.

16. Zeyuan Cao^#, Yunyi Xie^#, Le Yu, Yi Li, and Yan Wang*. Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. Stem Cell Research & Therapy 2020;11(1):329.

17. Qianmin Ou^#, Keqing Huang^#, Chuanqiang Fu, Chunlin Huang , Yifei Fang, Zhipeng Gu*, Jun Wu, Yan Wang*. Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid hydrogel with osteoimmunomodulatory and antibacterial activity for bone regeneration. Chemical Engineering Journal, 2020;382:123019.

18. Huan Chen^#, Xiaojun Huang^#, Chuanqiang Fu, Xiayi Wu, Yingying Peng, Xuefeng Lin*, and Yan Wang*. Recombinant Klotho protects human periodontal ligament stem cells by regulating mitochondrial function and the antioxidant system during H2O2-induced oxidative stress. Oxidative Medicine and Cellular Longevity. 2019;9261565.

19. Xiaojun Huang^#, Huan Chen^#, Yunyi Xie , Zeyuan Cao, Xuefeng Lin* and Yan Wang*. FoxO1 Overexpression Ameliorates TNF-α-Induced Oxidative Damage and Promotes Osteogenesis of Human Periodontal Ligament Stem Cells via Antioxidant Defense Activation, Stem cells international. 2019;2120453.

20. Yunyi Xie^#, Enbao He^#, Zeyuan Cao, Qianmin Ou, Yan Wang*. Effect of polyvinylphosphonic acid on resin-dentin bonds and cytotoxicity of MDPC-23. Journal of Prosthetic Dentistry. 2019 ;122(5):492.e1-492.e6.

21. Suya Chen , Qianmin Ou, Yan Wang*, Xuefeng Lin*. Short Implants (5-8 mm) Versus Long Implants (≥10 mm) with Augmentation in Atrophic Posterior Jaws: A Meta-Analysis of Randomized Controlled Trials. Journal of oral rehabilitation. 2019; 46 (12), 1192-1203.

22. Suya Chen^#, Qianmin Ou^#, Xuefeng Lin*, Yan Wang*.Comparison between a computer-aided surgical template and the free-hand method: A systematic review and meta-analysis. Implant Dentistry. 2019;28 (6), 578-589.

23. Qianmin Ou^#, Yingling Miao^#, Fanqiao Yang, Xuefeng Lin, Li-Ming Zhang * and Yan Wang *.Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells. Biomaterials Science, 2019;7(5):1973-1983.

24. Siqi Yao^#, Lingping Tan^#, Huan Chen, Xiaojun Huang, Wei Zhao*, and Yan Wang*.Potential Research Tool Of Stem Cells From Human Exfoliated Deciduous Teeth: Lentiviral Bmi-1 Immortalization With EGFP Marker. Stem Cells International, 2019;3526409.