胡晓莉 | 中山大学附属口腔医院

胡晓莉

主任医师博士生导师硕士生导师

导师简介

【学位/学历】

博士研究生 / 口腔临床医学博士

【学术简历】（注：时间正序写，从大学开始）

1991.09-1996.07 武汉大学本科

1998.09-2001.07 中山大学硕士

2006.01-2010.10 National University of Singapore 博士

【研究方向】

1.牙髓根尖周病诊疗的基础及临床研究

2.生物活性材料的作用机制及临床转化

【主持课题】

1. 2018.01-2021.12 粪肠球菌定植牙本质的特异性和非特异性黏附力机制研究国家自然科学基金面上项目，64万

2. 2024.1-2026.12可注射水凝胶递释增强型外泌体靶向Smurf2激活TGF-β1/Smad2信号通路促进伤口愈合的作用机制研究经费广东省自然科学基金项目15万

3. 2022.1-2024.12 DPSC源性外泌体蛋白FGD5激活Cdc42/p38 MAPK通路促进皮肤伤口愈合的作用机制研究广东省自然科学基金项目10万

4. 2026.01-2028.12疑难牙髓根尖周病的全周期数字化序列诊疗新技术广州地区临床高新、重大和特色技术项目 20万

【发表论文】

1) Huang L, Zhang X, Shao J, Zhou Z, Chen Y, Hu X*. Nanoscale chemical and mechanical heterogeneity of human dentin characterized by AFM-IR and bimodal AFM. Journal of Advanced Research. 2020；22:163-171.

2) Lin D, Zhou Z, Zhang M, Yao S, Yuan L, Xu M, Zhang X*, Hu X*.Electrical stimulations generated by P(VDF-TrFE) films enhance adhesion forces and odontogenic differentiation of dental pulp stem cells (DPSCs). ‌ACS Applied Materials & Interfaces. 2024;16(22):28029-28040.

3) Wang S, Zhou Z, Lv K, Liu Y, Feng L, Zhang M, Toh WS*, Hu X*. MiR-486-5p-modified DPSC-derived sEVs encapsulated in GelMA hydrogel promote wound healing by enhancing angiogenesis via Smurf2/TGF-β1 pathways. ‌International Journal of Biological Macromolecules. 2026;339(Pt 1):149887.

4) Hu X*, Zhong Y, Kong Y, Chen Y, Feng J, Zheng J*. Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of microRNAs. Stem Cell Research & Therapy. 2019;10:170.

5) Lei L, Huang Z, Feng J, Huang Z, Tao Y, Hu X*, Zhang X*. Loss of receptor tyrosine kinase-like orphan receptor 2 impairs the osteogenesis of mBMSCs by inhibiting signal transducer and activator of transcription 3. Stem Cell Research & Therapy. 2020;11:137.

6) Zhou Z, Zheng J*, Lin D, Xu R, Chen Y, Hu X*. Exosomes derived from dental pulp stem cells accelerate cutaneous wound healing by enhancing angiogenesis via the Cdc42/p38 MAPK pathway. International Journal of Molecular Medicine. 2022;50:143.

7) Yuan L, Liu Y, Lv K, Zhang M, Hu X*. Effects of poly(amidoamine) as an extrafibrillar demineralization agent on dentin bonding durability of deciduous teeth. Journal of Dentistry. 2025;154:105609.

8) Hu C, Wang H, Liao Y, Hu X*. An optimized method for establishing experimental rat periodontitis using "double-ligature" technique. Methods. 2026;248:20-29.

9) Wang X, Wang S, Yuan L, Liang ZH, Zhang XY, Lin DL, Hu X*. Influence of adhesion force on croRS gene expression and antibiotic resistance of Enterococcus faecalis. Journal of Biomedical Materials Research Part A. 2024;112:44-52.

10) Feng J, Fu D, Phan S, Hu X*, Xing Q*. P. Gingivalis LPS drives osteoclastogenesis and impairs osteoblast differentiation by suppressing Sema3A/Nrp1 Via TLR-4. International Dental Journal. 2025;75:103941.

11) Xu R, Zhou Z, Lin D, Yuan L, Wang S, Xu M, Chen Y, Hu X*. Enhancing effects of immobilized chondroitin sulfate on odontogenic differentiation of dental pulp stem cells and reparative dentin formation. Journal of Endodontics. 2023;49:852-860.

12) Tao YW, Xing Q, Li D, Quan J, Gao Y, Hu X*, Zhang X*. Association between increased inducible costimulator/inducible costimulator ligand expression with bone destruction in apical periodontitis. Journal of Endodontics. 2019;45:890-897.

13) Chen Y, Zheng J, Li D, Huang Z, Huang Z, Wang X, Zhang X, Hu X*. Three-dimensional position of mandibular third molars and its association with distal caries in mandibular second molars: a cone beam computed tomographic study. Clinical Oral Investigations. 2020 Sep;24(9):3265-3273.

14) Jiang J, Zhang N, Song H, Yang Y, Li J, Hu X*. Oridonin alleviates the inhibitory effect of lipopolysaccharide on the proliferation and osteogenic potential of periodontal ligament stem cells by inhibiting endoplasmic reticulum stress and NF-κB/NLRP3 inflammasome signaling. BMC Oral Health. 2023 Mar 9;23(1):137.

15) Li D, Tao Y, Cui M, Zhang W, Zhang X, Hu X*. External root resorption in maxillary and mandibular second molars associated with impacted third molars: a cone-beam computed tomographic study. Clinical Oral Investigations. 2019 Dec;23(12):4195-4203.

16) Hu XL, Ho B, Lim CT, Hsu CS. Thermal treatments modulate bacterial adhesion to dental enamel. Journal of Dental Research. 2011 Dec;90(12):1451-6.