陈晓丹 | 中山大学附属口腔医院

陈晓丹

副主任医师硕士生导师

导师简介

【学位 / 学历】

博士/研究生

【学术简历】

2007.09-2012.06 中山大学光华口腔医学院口腔医学学士

2012.09-2015.06 中山大学光华口腔医学院口腔修复学硕士

2015.09-2018.06 中山大学光华口腔医学院口腔临床医学博士

2017.05-2018.04 University of Michigan 口腔临床医学联合培养博士

【研究方向】

1.干细胞微环境调控与骨组织修复再生

2.人工智能在口腔修复中的应用

【主持课题】

1.2020-01至2022-12 Rspo1-LGR4轴调控辐射后BMSC命运维持骨稳态的作用及机制，国家自然科学基金青年项目，19万

2.2023-01至2026-12 基于CaM/CaMKII/Drp1通路探讨辐射微环境下BMSCs命运转归的机制及其对骨稳态的影响，广东省自然科学基金面上项目，10万

3.2020-01至2022-12 BMSC通过Rspo1-LGR4轴启动辐射后防御修复的作用及机制，广东省自然科学基金面上项目，10万

4.2023-04至2026-03 骨髓间充质干细胞线粒体动力学失衡介导放射性骨损伤发生发展的作用与机制研究，广州市科技计划，5万元

5.2019-01至2021-12 Rspo2-LGR4轴调控BMSC线粒体代谢维持骨稳态的作用及机制，高校基本科研业务经费中山大学青年教师培育项目，15万元

【发表论文】

1. Lin Ren^#, Xiaodan Chen^#, Ying Zheng^#, Jiayan Li, Jiali Yu, Linlin Ou, Gen Liu, Bin Cheng^*, Wei Seong Toh^*, Juan Xia^*. Mitochondrial dysfunction in mesenchymal stem cells impairs osteogenesis in radiation-induced bone injury via Ca2+-NFATc1-Fis1 pathway. Cell Death Dis. 2025, 17(1):69. (IF 9.6, 一区)

2. Jiayan Li^#, Xiaodan Chen^#, Linlin Ou, Lin Ren, Juan Xia*, Bin Cheng*. Myofibroblast-transformed MSCs promote osteoclastogenesis via mitochondrial transfer in ORNJ. Materials & Design. (Accepted) (IF 7.9, 二区)

3. Chen Xiaodan, Chen Lingling, Tan Jiali, Zhang Liping, Xia Juan*, Cheng Bin*, Zhang Weizhen*. Rspo1-LGR4 axis in BMSCs protects bone against radiation-induced injury through the mTOR-dependent autophagy pathway. J Cell Physiol. 2021, 236(6):4273-4289. (IF 4, 三区)

4. Li Jiayan^#, Chen Xiaodan^#, Ren Lin, Xijuan Chen, Tong Wu, Yun Wang, Xianyue Ren, Bin Cheng, Juan Xia. Type H vessel/platelet-derived growth factor receptor β+ perivascular cell disintegration is involved in vascular injury and bone loss in radiation-induced bone damage. Cell Prolif. 2023;e13406. doi:10.1111/cpr.13406 (IF 5.6, 一区)

5. Ren Lin^#, Chen Xiaodan^#, Chen Xiaobing, Li Jiayan, Cheng Bin*, Xia Juan*. Mitochondrial Dynamics: Fission and Fusion in Fate Determination of Mesenchymal Stem Cells. Front Cell Dev Biol. 2020;8:580070. (IF 4.3, 二区)

6. Chen Xiaodan, Tan Jiali, Feng Yi, Huang Lijia, Zhang Mei, Cheng Bin*. Autophagy in fate determination of mesenchymal stem cells and bone remodeling. World J Stem Cells. 2020,12(8):776-786. (IF 3.6, 三区)

7. Chen Xiaodan, Song Zijun, Chen Rui, Tan Shuyi, Huang Chunhuang, Liu Yanhui *, Cheng Bin*, Fu Qiang. Lysophosphatidic acid enhanced the osteogenic and angiogenic capability of osteoblasts via LPA1/3 receptor, Connect Tissue Res, 2019, 60(2):85-94. (IF 2.1, 三区)

8. Chen L, Carlton M, Chen X, Kaur N, Ryan H, Parker TJ, Lin Z, Xiao Y, Zhou Y. Effect of fibronectin, FGF-2, and BMP4 in the stemness maintenance of BMSCs and the metabolic and proteomic cues involved. Stem Cell Res Ther. 2021, 12(1):165.

9.Ruixin Chen^#; Zhichao Hao^#; Xiaodan Chen; Qiang Fu*; Yuanyuan Ma*; Neuropeptide Y enhances chondrogenic differentiation of ATDC5 cells via Y1 receptor signaling, Neuropeptides, 2020, 20:102022.

10. Rui Chen, Yanling She, Qiang Fu, Xiaodan Chen, Huacai Shi, Si Lei, Shanyao Zhou, Jun Ou, Yulin Liu. Differentially expressed coding and non-coding RNAs in CoCl2-induced cytotoxicity of C2C12 cells, Epigenomics, 2019, 11(4):423-438.

11. Su Z, Xu L, Dai X, Zhu M, Chen X, Li Y, Li J, Ge R, Cheng B, Wang Y. Prognostic and clinicopathological value of m6A regulators in human cancers: a meta-analysis. Aging (Albany NY). 2022, 14(21):8818-8838.

12. Xie Y, Hu C, Feng Y, Li D, Ai T, Huang Y, Chen X, Huang L, Tan J. Osteoimmunomodulatory effects of biomaterial modification strategies on macrophage polarization and bone regeneration. Regen Biomater. 2020, 7(3):233-245.

13. Tan J, Zhang M, Hai Z, Wu C, Lin J, Kuang W, Tang H, Huang Y, Chen X, Liang G. Sustained Release of Two Bioactive Factors from Supramolecular Hydrogel Promotes Periodontal Bone Regeneration. ACS Nano. 2019, 13(5):5616-5622.

14. Li D, Feng Y, Tang H, Huang L, Tong Z, Hu C, Chen X, Tan J. A Simplified and Effective Method for Generation of Experimental Murine Periodontitis Model. Front Bioeng Biotechnol. 2020 May 25;8:444. doi: 10.3389/fbioe.2020.00444.

15. Li X, Li Y, Li X, Chen X, Yang G, Yang L. Comparison of case-based learning combined with Rain Classroom teaching and traditional method in complete denture course for undergraduate interns. BMC Med Educ. 2022, 22(1):610.

16. 陈晓丹；向映辉；覃峰；杨志；谭淑仪；宋子珺；付强*；血小板源性生长因子与流体剪切力对成骨细胞增殖及c-fos表达的影响，中华口腔医学杂志（电子版）， 2015, 9(2):118-122.