胡钦朝 | 中山大学附属口腔医院

胡钦朝

主治医师副研究员硕士生导师

导师简介

【学位 / 学历】

博士 / 博士研究生

【学术简历】

2009.09-2014.06 中山大学口腔医学专业获学士学位

2014.09-2019.06 中山大学口腔临床医学（硕博连读）专业获博士学位

【研究方向】

1. 衰老与口腔上皮稳态及疾病

2. 脂代谢异常与口腔上皮恶性转化

【主持课题】

1. 2021-2023年：《CD36介导上皮细胞脂代谢失衡在口腔白斑发生发展中的作用与机制研究》，国家自然科学基金青年项目，24万

2. 2021年：《CD36通过PINK1-Parkin通路调控线粒体自噬促进口腔上皮恶性转化的作用与机制研究》，中国博士后科学基金特别资助（站中），18万

3. 2020-2022年：《K-ras突变联合4NQO诱发口腔黏膜癌前病变动物模型的建立》，广东省基础与应用基础研究基金区域联合基金青年项目，10万

4. 2020-2021年：《CD36介导线粒体脂代谢失衡在口腔上皮恶性转化中的作用与机制研究》，中国博士后科学基金面上项目，8万

【发表论文】

1. Hu Q, Wang S, Zhang W, Qu J, Liu GH. Unraveling brain aging through the lens of oral microbiota. Neural Regen Res. 2025, 20(7):1930-1943.

2. Hu Q#, Zhang B#, Jing Y#, Ma S#, Hu L#, Li J, Zheng Y, Xin Z, Peng J, Wang S, Cheng B, Qu J, Zhang W, Liu GH, Wang S. Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging. Protein Cell. 2024, 15(8):612-632.

3. Hu Q#, Peng J#, Jiang L, Li W, Su Q, Zhang J, Li H, Song M, Cheng B, Xia J, Wu T*. Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma. Cell Death Dis. 2020, 11(10):925.

4. Zhang J#, Peng J#, Wang S, Wang L, Sun Y, Xia J, Cheng B, Hu Q*. Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition. Cell Death Discov. 2025;11(1):30.

5. Wang S#, Wang L#, Li H#, Zhang J, Peng J, Cheng B, Song M, Hu Q*. Correlation analysis of plasma lipid profiles and the prognosis of head and neck squamous cell carcinoma. Oral Dis, 2024,30(2):329-341.

6. Wang L#, Wang S#, Zhang J, Peng J, Cheng B, Li H, Hu Q*. Radiotherapy upregulated immune checkpoints contribute to the development of second primary OSCC. Oral Dis, 2024,30(4):2188-2201.

7. Zhou J#, Hu Z#, Wang L#, Hu Q#, Chen Z#, Lin T, Zhou R, Cai Y, Wu Z, Zhang Z, Yang Y, Zhang C, Li G, Zeng L, Su K, Li H, Su Q, Zeng G, Cheng B, Wu T*. Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma. Microbiome. 2024;12(1):193.

8. Peng J#, Hu Q#, Wang C, Zhang J, Wang S, Wang L, Xia J, Cheng B. Depletion of Gr1+ myeloid cells attenuates high-fat-diet-aggravated esophageal squamous cell carcinoma in mice. Carcinogenesis. 2023, 44(7):587-595.

9. Wang K#, Liu H#, Hu Q#, Wang L#, Liu J#, Zheng Z, Zhang W, Ren J, Zhu F, Liu G*. Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal Transduct Target Ther, 2022, 7(1): 374.

10. Peng J#, Hu Q#, Chen X, Wang C, Zhang J, Ren X, Wang Y, Tao X, Li H, Song M, Cheng B, Wu T, Xia J*. Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells. Cell Death Dis, 2021, 12(10):946.

11. 胡钦朝, 姜徕博, 彭建敏, 吴桐, 程斌, 夏娟. 利用荧光染料CFSE分选衰老细胞的探究[J]. 口腔生物医学, 2020, 11(2): 81-85.

【参编教材与论著】

2022年参编《口腔黏膜病标准数据集》科学出版社 9787030716989

【获奖及学术荣誉】

1. 2024年中华口腔医学会青年科学家报告会“二等报告”

2. 2021年全国口腔黏膜病学学术大会口腔黏膜病研究论坛“风采之星”

【社会兼职】

1. 中华口腔医学会口腔黏膜病专业委员会青年委员、工作秘书

2. 中华口腔医学会口腔生物医学专业委员会青年委员

3. 广东省口腔医学会口腔黏膜病专业委员会委员

4. 中华口腔医学会青年科研通讯员

【联系方式】

地址：广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院（510055）

电话：020-83741891

邮箱：huqch3@mail.sysu.edu.cn

【研究方向】

1. 衰老与口腔上皮稳态及疾病

2. 脂代谢异常与口腔上皮恶性转化

【主持课题】

【发表论文】

1. Hu Q, Wang S*, Zhang W*, Qu J*, Liu GH*. Unraveling brain aging through the lens of oral microbiota. Neural Regen Res. 2025, 20(7):1930-1943.

2. Hu Q#, Zhang B#, Jing Y#, Ma S#, Hu L#, Li J, Zheng Y, Xin Z, Peng J, Wang S, Cheng B, Qu J*, Zhang W*, Liu GH*, Wang S*. Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging. Protein Cell. 2024, 15(8):612-632.

3. Hu Q#, Peng J#, Jiang L, Li W, Su Q, Zhang J, Li H, Song M, Cheng B*, Xia J*, Wu T*. Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma. Cell Death Dis. 2020, 11(10):925.

4. Zhang J#, Peng J#, Wang S, Wang L, Sun Y, Xia J*, Cheng B*, Hu Q*. Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition. Cell Death Discov. 2025;11(1):30.

5. Wang S#, Wang L#, Li H#, Zhang J, Peng J, Cheng B*, Song M*, Hu Q*. Correlation analysis of plasma lipid profiles and the prognosis of head and neck squamous cell carcinoma. Oral Dis, 2024,30(2):329-341.

6. Wang L#, Wang S#, Zhang J, Peng J, Cheng B*, Li H*, Hu Q*. Radiotherapy upregulated immune checkpoints contribute to the development of second primary OSCC. Oral Dis, 2024,30(4):2188-2201.

8. Peng J#, Hu Q#, Wang C, Zhang J, Wang S, Wang L, Xia J*, Cheng B*. Depletion of Gr1+ myeloid cells attenuates high-fat-diet-aggravated esophageal squamous cell carcinoma in mice. Carcinogenesis. 2023, 44(7):587-595.

9. Wang K#, Liu H#, Hu Q#, Wang L#, Liu J#, Zheng Z, Zhang W, Ren J*, Zhu F*, Liu G*. Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal Transduct Target Ther, 2022, 7(1): 374.

10. Peng J#, Hu Q#, Chen X, Wang C, Zhang J, Ren X, Wang Y, Tao X, Li H, Song M, Cheng B*, Wu T*, Xia J*. Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells. Cell Death Dis, 2021, 12(10):946.