【学位 / 学历】

博士 / 博士研究生

【学术简历】

2008-2013 中山大学口腔医学专业获学士学位

2013-2015 中山大学口腔临床医学专业获硕士学位

2015-2016 中山大学口腔临床医学专业获博士学位

【研究方向】

口腔种植相关软硬组织再生免疫调控与转化研究

【主持课题】

2014-2025年：《CMC/ACP纳米复合体经TRPC4介导钙内流活化TLR4-MAKP/NF-κB的免疫调控机制研究》，广州市科技基础与应用基础研究专题青年博士启航项目，5万

【发表论文】

1.Liu Chengwu#, Xu Leyao#, Feng Junming#, Yang Bo, Chen Kaidi, Liu Yuanxiang, Wu Xiayi, Wu Shiyu, Li Zhipeng, Chen Shoucheng*, Chen Zhuofan*. Fluorine-Incorporated Biogenic Hydroxyapatite Enhances Socket Bone Healing via Addressing Macrophage-Mediated Inflammatory Response. Bioengineering. 2025; 12(4): 396.

2.Xie Lv#, Shan Zhengjie#, Zhang Linjun#, He Xinyi, Gui Mixiao, Zhang Yingye, Xue Junlong, Ye Chen, Zou Yang, Su Mengxi, Chen Zhuofan, Wu Shiyu*, Xiao Yin*, Chen Zetao*. Metal Ion “Adjuvant” [Si-O4] Tetrahedron Addresses Coagulation Interruption and Promotes Multi-Tissue Regeneration via Smart Ionic Capturing and Cell Membrane Transporting. Advanced Functional Materials. 2025, 35(10): 2416743.

3.Liu Guanqi#, Deng Shudan#, Liu Runzhong, Liu Yuanxiang, Liu Quan, Wu Shiyu, Chen Zhuofan*, Liu Runheng*. Precise multi-factor immediate implant placement decision models based on machine learning. Sci Rep. 2025, 15(1):5143.

4.Li Chuangji#, Su Mengxi#, Mai Meihua#, Guo Zefeng, Li Ye, Chen Shoucheng, Liu Quan, Chen Danying, Wu Xiayi, Chen Zetao*, Chen Zhuofan*, Wu Shiyu*. Calcium enrichment activity initiates extracellular calcium influx-dependent inflammatory response of biologically-derived hydroxyapatite. Materials Today Bio. 2024, 28:101231.

5.Wu Xiayi#, Xu Chunxin#, Feng Junming#, Wu Shiyu, Liu Runheng, Qiao Wei, Luo Xin, Chen Shoucheng, Li Zhipeng*, Chen Zhuofan*. Fluorinated Porcine Bone-Derived Hydroxyapatite Promotes Vascularized Osteogenesis by Coordinating Human Bone Marrow Mesenchymal Stem Cell/Human Umbilical Vein Endothelial Cell Complexes. Bioengineering (Basel). 2024, 11(12):1287.

6.Chen Kaidi#, Ha Seongmin#, Xu Leyao, Liu Chengwu, Liu Yuanxiang, Wu Xiayi, Li Zhipeng, Wu Shiyu*, Yang Bo*, Chen Zhuofan*. Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation. J Transl Med. 2024, 22(1):437.

7.Su Mengxi#, Li Chuangji#, Deng Shudan#, Xu Leyao, Shan Zhengjie, Xing Yihan, Li Xiyan, Li Ye, Liu Xingchen, Zhong Xinyi, Chen Kaidi, Chen Shoucheng, Liu Quan, Wu Xiayi, Chen Zetao*, Wu Shiyu*, Chen Zhuofan*. Balance between the CMC/ACP nanocomplex and blood assimilation orchestrates immunomodulation of the biomineralized collagen matrix. ACS Applied Materials & Interfaces. 2023, 15(50):58166-58180.

8.Li Xiyan#, Li Chuangji, Su Mengxi, Zhong Xingyi, Xing Yihan, Shan Zhengjie, Chen Shoucheng, Liu Xingchen, Wu Xiayi, Liu Quan, Li Ye, Wu Shiyu*, Chen Zhuofan*. Optimizing the biodegradability and osteogenesis of biogenic collagen membrane via fluoride-modified polymer-induced liquid precursor process. Science and Technology of Advanced Materials. 2023, 24(1):2186690.

9.Xing Yihan#, Zhong Xinyi#, Chen Shoucheng, Wu Shiyu, Chen Kaidi, Li Xiyan, Su Mengxi, Liu Xingchen, Zhong Juan, Chen Zetao, Pan Haobo*, Chen Zhuofan*, Liu Quan*. Optimized osteogenesis of porcine bone-derived xenograft through surface coating of magnesium-doped nanohydroxyapatite. Biomed Mater. 2023, 18(5).

10.Luo Pu#, Huang Ruoxuan#, Wu You#, Liu Xingchen, Shan Zhengjie, Gong Li, Deng Shudan, Liu Haiwen, Fang Jinghan, Wu Shiyu, Wu Xiayi, Liu Quan, Chen Zetao, Yeung K.W. Kelvin, Qiao Wei*, Chen Shoucheng*, Chen Zhuofan*. Tailoring the multiscale mechanics of tunable decellularized extracellular matrix (dECM) for wound healing through immunomodulation. Bioact Mater. 2023, 28:95-111.

11.Wu Shiyu#, Shan Zhengjie#, Xie Lv#, Su Mengxi, Zeng Peisheng, Huang Peina, Zeng Lingchan, Sheng Xinyue, Li Zhipeng, Zeng Gucheng*, Chen Zhuofan*, Chen Zetao*. Mesopore controls responses of blood clot-immune complex via modulating fibrin network. Advanced Science. 2022, 9(3): e2103608.

12.Wu You#，Chen Shoucheng#, Luo Pu#, Deng Shudan, Shan Zhengjie, Fang Jinghan, Liu Xingchen, Xie Jiaxin, Liu Runheng, Wu Shiyu, Wu Xiayi, Chen Zetao, Yeung K.W. Kelvin*, Liu Quan*, Chen Zhuofan*. Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite. Acta Biomaterialia. 2022, S1742-7061(22)00080-0.

13.李歆, 刘开政, 武诗语, 刘远翔, 黄宝鑫, 乔威, 潘浩波, 陈卓凡.口腔种植治疗中骨再生材料的研究现状. 中国口腔种植学杂志，2024，29(4):371-377.

14.武诗语，陈卓凡，黄宝鑫，陈泽涛，刘远翔.单纯应用低替代率异种骨增量材料行上颌窦底提升的思考. 中国口腔种植学杂志，2023，28(5):327-331.

15.苏梦溪，武诗语，单正杰，谢律，陈泽涛，陈卓凡.基于血凝块纤维网管控的凝血-免疫复合体免疫微环境重塑. 中国口腔种植学杂志，2022，27(6):365-370.

16.刘成武，刘远翔，李志鹏，刘泉，武诗语，吴夏怡，陈泽涛，黄宝鑫，陈卓凡.两种不同螺纹设计的牙种植体在犬颌骨中骨结合的对比研究. 中国口腔种植学杂志，2021，26(4): 226-231.

【社会兼职】

1. 广东省口腔医学会口腔种植学专业委员会青年委员

2. 广东省精准医学应用学会口腔修复种植分会委员

3. Regenerative medicine and dentistry青年编委

【联系方式】

地址：广东省广州市天河区华夏路49号津滨腾越大厦21楼

邮箱：wushy55@mail.sysu.edu.cn