【学位 / 学历】

博士 / 研究生

【学术简历】

1999.09-2004.06 中山大学口腔临床医学专业获学士学位

2004.07-2008.08 中山大学口腔临床医学医师

2008.09-2011.06 中山大学口腔临床医学专业获硕士学位

2011.09-2014.06 中山大学口腔临床医学专业获博士学位

2014.07-2015.12 中山大学口腔临床医学医师

2016.01-2017.12 中山大学口腔临床医学主治医师

2018.01-2022.12 中山大学口腔临床医学副主任医师

2019.08-2020.08 美国密西根大学（国家公派）基础医学访问学者

2023.01至今 中山大学口腔临床医学主任医师

【研究方向】

1. 口腔黏膜上皮恶性转化机制研究

2. 口腔黏膜病防治

【主持课题】

1. 2024-2027年：《牙龈卟啉单胞菌调控上皮代谢重编程诱导免疫微环境失

衡在口腔白斑发生发展中的作用与机制》，国家自然科学基金（面上项目），48万

2. 2022-2024年：《IL-1β-ATF4-SLC7A11轴介导氧化还原稳态失衡在口腔白斑发生发展中的作用》，广州市科技计划项目，5万

【发表论文】

1.Jiaying Zhou, Zixuan Hu , Lei Wang, Qinchao Hu, Zixu Chen, Tao Lin, Rui Zhou, Yongjie Cai, Zhiying Wu, Zhiyi Zhang, Yi Yang, Cuijuan Zhang, Guibo Li, Lingchan Zeng, Kai Su, Huan Li, Qiao Su, Gucheng Zeng, Bin Cheng, Tong Wu*. Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma. Microbiome. 2024;12(1):193.

2.Jiaying Zhou, Haoyuan Wu, Xiaojing Hong, Yunyi Huang, Bo Jia, Jiabin Lu, Bin Cheng, Meng Xu, Meng Yang, Tong Wu*. A pathology-based diagnosis and prognosis intelligent system for oral squamous cell carcinoma using semi-supervised learning. Expert Systems with Applications. 2024;2534:24242.

3.Wang W, Zheng J, Hong X, Zhou J, Xiong Y, Yang H, Li S, Chen G, Su Q, Li W, Cheng B, Fu J, Wu T*. Micro-environment triple-responsive hyaluronic acid hydrogel dressings to promote antibacterial activity, collagen deposition, and angiogenesis for diabetic wound healing. J Mater Chem B. 2024;12(19):4613-4628.

4.Chen W, Chen X, Wang L, Yang R, Zhang W, Zhang S, Xia J, Cheng B*, Wu T*, Ren X*. TIPE3 represses head and neck squamous cell carcinoma progression via triggering PGAM5 mediated mitochondria dysfunction. Cell Death Dis. 2023;14(4):251.

5.Jia-Ying Zhou, Qing-Hua Shen, Xiao-Jing Hong, Wu-Ya Zhang, Qiao Su, Wu-Guo Li, Bin Cheng, Cai-Ping Tan, Tong Wu*. Synergization of an endoplasmic reticulum-targeted iridium(III) photosensitizer with PD-L1 inhibitor for oral squamous cell carcinoma immunotherapy. Chem. Eng. J. 2023;474:145516.

6.Zhou J, Zhou R, Tan P, Cheng B, Ma L, Wu T*. Oral lichenoid lesion simultaneously associated with Castleman's disease and papillary thyroid carcinoma: a rare case report. BMC Oral Health. 2022;22(1):572.

7.Zhou JY, Wang WJ, Zhang CY, Ling YY, Hong XJ, Su Q, Li WG, Mao ZW, Cheng B, Tan CP, Wu T*. Ru(II)-modified TiO2 nanoparticles for hypoxia-adaptive photo-immunotherapy of oral squamous cell carcinoma. Biomaterials. 2022;289:121757.

8.Hu Z#, Zhou J#, Li Y, Luan Y, Li H, Jia B, Xie Z, Cheng B, Wu T*. Peripheral immune signature resembles tumor microenvironment and predicts clinical outcomes in head and neck squamous cell carcinoma. Front Immunol. 2022;13:915207.

9.Jianmin Peng; Qinchao Hu; Xijuan Chen; Chunyang Wang; Jiayu Zhang; Xianyue Ren; Yun Wang; Xiaoan Tao; Huan Li; Ming Song; Bin Cheng; Tong Wu*; Juan Xia*. Diet-induced obesity accelerates oral carcinogenesis by recruitment and functional enhancement of myeloid-derived suppressor cells. Cell Death Dis. 2021, 12(10): 946.

10.Zhang S, Ren X, Wang C, Chen X, Cao R, Liu Q, Pan X, Zhou J, Zhang W, Tang X-R, Cheng B, Wu T*. Comprehensive Characterization of Immune Landscape Based on Epithelial-Mesenchymal Transition Signature in OSCC: Implication for Prognosis and Immunotherapy. Front Oncol. 2021;11:587862.

11.Zhou J, Li H, Cheng B, Cao R, Zou F, Yang D, Liu X, Song M, Wu T*. Derivation and Validation of a Prognostic Scoring Model Based on Clinical and Pathological Features for Risk Stratification in Oral Squamous Cell Carcinoma Patients: A Retrospective Multicenter Study. Front Oncol. 2021;11:652553.

12.Hu Q, Peng J, Jiang L, Li W, Su Q, Zhang J, Li H, Song M, Cheng B, Xia J, Wu T*. Metformin as a senostatic drug enhances the anticancer efficacy of CDK4/6 inhibitor in head and neck squamous cell carcinoma. Cell Death Dis. 2020;11(10):925.

【参编教材与论著】

2022年 主编《口腔黏膜病标准数据集》科学出版社 978-7-03-071698-9

【获奖及学术荣誉】

1. 2023 年 中山大学第十一届本科教育教学成果奖一等奖

2. 2021 年 广东省2021年科技进步二等奖

【社会兼职】

1. 中华口腔医学会黏膜病学专委会委员、学术秘书

2. 广东省口腔医学会黏膜病学专委会常务委员

【联系方式】

地址：广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院（510055）

电话：020-83741891

邮箱：wutong23@mail.sysu.edu.cn