【学位 / 学历】
博士 / 研究生
【学术简历】
1985.09-1991.07 华西医科大学口腔医学院口腔医学专业学士学位
1997.09-2000.07 华西医科大学口腔医学院口腔正畸学专业获硕士学位
2000.09-2003.07 四川大学华西口腔医学院口腔正畸学专业博士学位
【研究方向】
1.正畸牙移动相关的基础及临床转化研究
2.生物力学与生物材料相关研究
3.牙周骨改建相关研究
【主持课题】
1. 2021-2024年：《凋亡小体在正畸牙移动骨改建中的作用机制研究》，国家自然科学基金面上项目，55万
2. 2020-2023年：《正畸应力作用下 IL-20 经神经-免疫通信调控破骨细胞活化的机制研究》，国家自然科学基金面上项目，55万
3. 2023.1-2028.12年：《正畸干预联合CPAP与单纯CPAP治疗阻塞性睡眠呼吸障碍的前瞻性随机对照临床研究》，中山大学5010临床研究计划项目，60万
4. 2022-2024年：《正畸牙移动中IL-20通过HIF-1α调节巨噬细胞自噬的机制研究》，广东省自然面上项目，10万
5. 2021-2024年：《4D数字化动态微笑牙移动模型引导的隐形矫治设计 》，中国牙病防治基金，27万
【发表论文】
1. Ziqi Gan, Zecong Xiao, Zhen Zhang, Yang Li, Chao Liu, Xin Chen, Yuanbo Liu, Dongle Wu, Chufeng Liu, Xintao Shuai, and Yang Cao*. Stiffness-tuned and ROS-sensitive hydrogel incorporating complement C5a receptor antagonist modulates antibacterial activity of macrophages for periodontitis treatment. Bioact Mater. 2023;25:347-359. doi: 10.1016/j.bioactmat.2023.01.011. PMID: 36852104; PMCID: PMC9958411. (Q1, IF=18, 最后通讯)
2. Bowen Meng, Benyi Yang, Yan Qu, Yuanbo Liu, Dongle Wu, Chaoran Fu, Yifan He, Xi Chen, Chufeng Liu, Xiaoxing Kou, and Yang Cao*. Dual Role of Interleukin-20 in Different Stages of Osteoclast Differentiation and Its Osteoimmune Regulation during Alveolar Bone Remodeling. Int J Mol Sci. 2023;24(4). doi: 10.3390/ijms24043810. PMID: 36835229; PMCID: PMC9961846. (Q1, IF=4.9, 最后通讯)
3. Zhengyuan Chen, Liyi Gan, Xin Chen, Jinxuan Zheng, Songtao Shi, Liping Wu, and Yang Cao*. LncRNA HOTAIRM1 promotes dental follicle stem cell-mediated bone regeneration by regulating HIF-1α/KDM6/EZH2/H3K27me3 axis. J Cell Physiol. 2023;238(7):1542-57. doi: 10.1002/jcp.31028. PMID: 37120836. (Q1, IF=4.5, 最后通讯)
4. Lidi Deng, Liping Wu, Dongru Chen and Yang Cao*. SNHG1 knockdown promotes osteogenic differentiation of hDFSCs through anti-oxidative stress mediated by autophagy. J Cell Physiol. 2024;239(6):e31283. doi: 10.1002/jcp.31283. PMID: 38651182. (Q1, IF=4.5, 最后通讯)
5. Bowen Meng, Dongle Wu, Yangfan Cheng, Peina Huang, Yuanbo Liu, Lei Gan, Chufeng Liu, and Yang Cao*. Interleukin-20 differentially regulates bone mesenchymal stem cell activities in RANKL-induced osteoclastogenesis through the OPG/RANKL/RANK axis and the NF-κB, MAPK and AKT signalling pathways. Scand J Immunol. 2020;91:e12874 . doi: 10.1111/sji.12874. PMID: 32090353 (Q2, IF=4.1, 最后通讯)
6. Dongle Wu, Xuan Sun, Yiwei Zhao, Yuanbo Liu, Ziqi Gan, Zhen Zhang, Xin Chen, and Yang Cao*. Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy. Bioengineering (Basel). 2023;10(3). doi: 10.3390/bioengineering10030365. PMID: 36978756; PMCID: PMC10045081. (Q2, IF=3.8, 最后通讯)
7. Yuanbo Liu, Yilong Ai, Xuan Sun, Bowen Meng, Xi Chen, Dongle Wu, Lei Gan, Benyi Yang, Chaoran Fu, Yilin Wu, and Yang Cao*. Interleukin-20 Acts as a Promotor of Osteoclastogenesis and Orthodontic Tooth Movement. Stem Cells Int. 2021;2021:5539962. doi: 10.1155/2021/5539962. PMID: 34122555 PMCID: PMC8172288 (Q2, IF=3.8, 最后通讯)
8. Benyi Yang, Chaoran Fu, Yilin Wu, Yuanbo Liu, Zhen Zhang, Xin Chen, Dongle Wu, Ziqi Gan, ngyuan Chen, and Yang Cao*. γ-Secretase inhibitors suppress IL-20-mediated osteoclastogenesis via Notch signalling and are affected by Notch2 in vitro. Scand J Immunol. 2022;96(2):e13169. doi: 10.1111/sji.13169. PMID: 35384009. (Q2, IF=4.1, 最后通讯)
9. Xin Chen, Chao Liu, Rongcheng Yu, Ziqi Gan, Zhen Zhang, Zhengyuan Chen, Yuanbo Liu, Dongle Wu, Xinyi Yu, Chufeng Liu, and Yang Cao*. Interaction between ferroptosis and TNF-α: Impact in obesity-related osteoporosis. FASEB J. 2023;37(6):e22947. doi: 10.1096/fj.202201958R. PMID: 37199646. (Q1, IF=4.4, 最后通讯)
10. Xi Chen, Yuanbo Liu, Bowen Meng, Dongle Wu, Yilin Wu, and Yang Cao*. Interleukin-20 inhibits the osteogenic differentiation of MC3T3-E1 cells via the GSK3β/β-catenin signalling pathway. Arch Oral Biol. 2021;125:105111. doi: 10.1016/j.archoralbio.2021.105111. PMID: 33798924 (Q2, IF=2.2, 最后通讯)
11. Chaoran Fu, Lei Gan, Benyi Yang, Yilin Wu, Bowen Meng, Dongle Wu, Jinxuan Zheng, and Yang Cao*. Inhibitory effect of infliximab on orthodontic tooth movement in male rats. Arch Oral Biol. 2022;144:105573. doi: 10.1016/j.archoralbio.2022.105573. PMID: 36341994. (Q2, IF=2.2, 最后通讯)
12. Yangfan Cheng, Peina Huang, Bowen Meng, Lei Gan, Dongle Wu and Yang Cao*. Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats. Arch Oral Biol,2019;98: 81–86.PMID: 30465937 (Q2, IF=2.2, 最后通讯)
13. Dongle Wu, Bowen Meng, Yangfan Cheng, Lei Gan, Peina Huang, and Yang Cao*. The effect of risedronate on orthodontic tooth movement in ovariectomized rats. Arch Oral Biol. 2019;105:59-64. doi: 10.1016/j.archoralbio.2019.06.002 PMID: 31276939 (Q2, IF=2.2, 最后通讯)
14. Peina Huang , Jieyun Xu, Lv Xie , Guangqi Gao, Shoucheng Chen, Zhuohong Gong, Xiaomei Lao, Zhengjie Shan, Jiamin Shi, Zhaocai Zhou, Zhuofan Chen, and Yang Cao*, Yan Wang*, Zetao Che*. Improving hard metal implant and soft tissue integration by modulating the “inflammatory-fibrous complex” response. Bioactive Materials. 2023;20:42-52. doi: 10.1016/j.bioactmat.2022.05.013. PMID: 35633873; PMCID: PMC9127122. (Q1, IF=18, 共同通讯)
15. Guanqi Liu, Xuan Zhou, Linjun Zhang, Yang Zou, Junlong Xue, Ruidi Xia, Nuerbiya Abuduxiku, Xuejing Gan, Runheng Liu, Zhuofan Chen*, Yang Cao*, and Zetao Chen*. Cell-free immunomodulatory biomaterials mediated in situ periodontal multi-tissue regeneration and their immunopathophysiological processes. Mater Today Bio. 2022;16:100432. doi: 10.1016/j.mtbio.2022.100432. PMID: 36204216; PMCID: PMC9530615. (Q1, IF=8.7, 共同通讯)
16. Yang Li, Yi Li, Chao Liu, Xinyi Yu, Ziqi Gan, Lusai Xiang, Jinxuan Zheng, Bowen Meng, Rongcheng Yu, Xin Chen, Xiaoxing Kou*, Yang Cao*, and Tingting Ai*. Mechanical force-activated CD109 on periodontal ligament stem cells governs osteogenesis and osteoclast to promote alveolar bone remodeling. Stem Cells Transl Med. 2024;13(8):812-25. doi: 10.1093/stcltm/szae035. PMID: 38885217; PMCID: PMC11328932. (Q1, IF=5.4, 共同通讯)
17. Haotian Luo, Hio Cheng Ieong, Runze Li, Delan Huang, Danying Chen, Xin Chen, Yuqing Guo, Yangqiao Qing, Bingyan Guo, Ruoyu Li, Yungshan Teng, Wenfeng Li, Yang Cao*, Chen Zhou*, and Weicai Wang*. Lhx6 deficiency causes human embryonic palatal mesenchymal cell mitophagy dysfunction in cleft palate. Mol Med. 2024;30:183. doi: 10.1186/s10020-024-00960-2. PMID: 39438838; PMCID: PMC11494960. (Q1, IF=6.0, 共同通讯)
18. Qingru Niu, Huan Chen, Qianmin Ou, Shuqing Yang, Yingying Peng, Yunyi Xie, Le Yu, Zhilan Cheng, Yang Cao*, and Yan Wang*. Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy. J Orthop Surg Res. 2023;18(1):400. doi: 10.1186/s13018-023-03849-8. PMID: 37264407; PMCID: PMC10236596. (Q1, IF=2.8, 共同通讯)
19. Haotian Luo, Danying Chen, Ruoyu Li, Runze Li, Yungshan Teng, Yang Cao*, Xuenong Zou*, Weicai Wang*, and Chen Zhou*. Genetically engineered CXCR4-modified exosomes for delivery of miR-126 mimics to macrophages alleviate periodontitis. J Nanobiotechnology. 2023;21(1):116. doi: 10.1186/s12951-023-01863-w. PMID: 36991451; PMCID: PMC10061745. (Q1, IF=10.6, 共同通讯)
20. Chen Zhou, Danying Chen, Jianhan Ren, Delan Huang, Runze Li, Haotian Luo, Chenyu Guan, Yang Cao*, and Weicai Wang*. FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. J Cell Mol Med. 2021;25(6):3051-62. doi: 10.1111/jcmm.16351. PMID: 33580754; PMCID: PMC7957265. (Q2, IF=4.3, 共同通讯)
21. R. Li, W. Li, Y. Teng, R. Li, S. Kong, X. Chen, H. Luo, D. Chen, Y. Guo, Y. Qing, H.C. Leong, B. Guo, M. Chen, Z. Pan, S. Zheng, Y. Deng, Y. Cao*, C. Zhou*, X. Zou*, and W. Wang*, Ameliorating macrophage pyroptosis via ANXA1/NLRP3/Caspase-1/GSDMD pathway: Ac2-26/OGP-loaded intelligent hydrogel enhances bone healing in diabetic periodontitis. Biofabrication 17 (2025). ( IF=8.2, 共同通讯)
22. C. Zhou, Z. Feng, J. Ren, H. Luo, H.C. Ieong, R. Li, Y. Qing, Y. Guo, B. Guo, Z. Huang, Y. Cao*, and W. Wang*, The effects of clinical crown length on the sagittal movement of maxillary central incisor in clear aligner treatment: a finite element exploration. BMC Oral Health 25 (2025) 357. ( IF=2.6, 共同通讯)
23. G. Liu, R. Xia, M. Gui, L. Zhang, X. Zhou, J. Xue, Y. Cai, Y. Cao*, Y. Xiao*, and Z. Chen*, Turn Hood into Good: Recycling Silicon from Mesoporous Silica Nanoparticles through Magnesium Modification to Lower Toxicity and Promote Tissue Regeneration. ACS Nano 18 (2024) 32932-32949. ( IF=15.8, 共同通讯)
【参编教材与论著】
1. 2021年11月 参编《无托槽隐形矫治技术拔牙病例精粹》 辽宁科学技术出版社，978-7-5591-2205-6
2. 2020年8月 参编《中国青少年隐形矫治专家共识》 四川大学出版社。9787569019629
【获奖及学术荣誉】
1. 2021年 广东医院优秀临床科主任
2. 2019年 羊城好医生
【社会兼职】
1. 中华口腔医学会正畸专业委员会副主任委员
2. 广东省口腔医学会正畸专业委员会常务副主任委员
3. 广东省医院协会口腔数字化材料技术管理专业委员会 常务副主任委员
4. 广东省精准医学会咬合颞下颌关节分会常务副主任委员
5. 中国整形协会牙颌颜面医疗美容分会常务理事
6. 广东省口腔医学会医院感染控制与管理委员会常务委员
【联系方式】
地址：广州市陵园西路56号中山大学附属口腔医院
电话：020-83802804
邮箱：caoyang@mail.sysu.edu.cn
