王彦
研究员 博士生导师
导师简介

    王彦, 博士, 现任中山大学光华口腔医学院研究员, 博士生导师，为中山大学“百人计划”引进人才。1993 年获中国卫生部日本厚生省世川医学奖学金赴日本大阪大学留学，于2000 年获医学博士学位。 2000 年至2010 年先后为美国University of Pennsylvania 博士后、Research Associate，主要从事人类肿瘤病毒（KSHV，EBV）致瘤机制的研究。在病毒DNA 复制机制的系列研究中有了重要的突破，取得了一系列原创性成果： 鉴定了KSHV 裂解期DNA复制的起始部位和重要的基因序列；鉴定并阐明了 ORF50、K8、PPF 等KSHV病毒蛋白在病毒DNA 复制过程中的作用。特别是鉴定了以Topo I/II、PARP1、MSH6、Ku86、RecQL等为代表的宿主蛋白在病毒复制过程中的重要作用，这些研究成果为研发以宿主蛋白为靶点的新型抗病毒药物提供了重要的理论依据。相关的研究成果已发表在国际一流专业杂志，并受到研究领域学者的关注。2010 年入选中山大学引进国外杰出人才“百人计划”。回国后从事教学和科研工作。主要研究方向：1、口腔干细胞分化和干性维持的分子机制及组织再生；2、人类肿瘤病毒（KSHV、EBV）致病的分子机制；3、抗病毒药物研发。回国后作为项目负责人主持国家自然科学基金面上2项、广东省科学技术厅/广东省引进创新科研团队“重大人类致病病毒特异性药物的研发与免疫细胞的再生工程”子项目以及“百人计划”启动项目等。回国后在Chemical Engineering Journal 、Oxidative Medicine and Cellular Longevity、Stem Cell Research & Therapy、Cell Proliferation、Dental Materials、Joural of Virology、Stem Cells International、PLoS Pathogens等杂志发表32篇SCI论文。

近三年代表性论文：

  1. Zeyuan Cao#, Yunyi Xie#, Le Yu, Yi Li, and Yan Wang*. Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. Stem Cell Research & Therapy 2020 Jul 31;11(1):329. (*通讯作者）
  2. Qianmin Ou#, Keqing Huang#, Chuanqiang Fu, Chunlin Huang , Yifei Fang, Zhipeng Gu*, Jun Wu, Yan Wang*. Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid hydrogel with osteoimmunomodulatory and antibacterial activity for bone regeneration. Chemical Engineering Journal, 2020; 382:123019. (*通讯作者）
  3. Huan Chen#, Xiaojun Huang#, Chuanqiang Fu, Xiayi Wu, Yingying Peng, Xuefeng Lin*, and Yan Wang*. Recombinant Klotho protects human periodontal ligament stem cells by regulating mitochondrial function and the antioxidant system during H2O2-induced oxidative stress. Oxidative Medicine and Cellular Longevity. 2019; 9261565. (*通讯作者）
  4. Xiaojun Huang#, Huan Chen#, Yunyi Xie , Zeyuan Cao, Xuefeng Lin* and Yan Wang*. FoxO1 Overexpression Ameliorates TNF-α-Induced Oxidative Damage and Promotes Osteogenesis of Human Periodontal Ligament Stem Cells via Antioxidant Defense Activation, Stem cells international. 2019;2019:2120453. (*通讯作者）
  5. Yunyi Xie#, Enbao He#, Zeyuan Cao, Qianmin Ou, Yan Wang*. Effect of polyvinylphosphonic acid on resin-dentin bonds and cytotoxicity of MDPC-23. Journal of Prosthetic Dentistry. 2019 ;122(5):492.e1-492.e6.（*通讯作者）
  6. Suya Chen , Qianmin Ou, Yan Wang*, Xuefeng Lin*. Short Implants (5-8 mm) Versus Long Implants (≥10 mm) with Augmentation in Atrophic Posterior Jaws: A Meta-Analysis of Randomized Controlled Trials. Journal of oral rehabilitation. 2019; 46 (12), 1192-1203. (*通讯作者）
  7. Suya Chen#, Qianmin Ou#, Xuefeng Lin*, Yan Wang*.Comparison between a computer-aided surgical template and the free-hand method: A systematic review and meta-analysis. Implant Dentistry. 2019;28 (6), 578-589. (通讯作者）
  8. Qianmin Ou#, Yingling Miao#, Fanqiao Yang, Xuefeng Lin, Li-Ming Zhang * and Yan Wang *.Zein/gelatin/nanohydroxyapatite nanofibrous scaffolds are biocompatible and promote osteogenic differentiation of human periodontal ligament stem cells. Biomaterials Science, 2019;7(5):1973-1983.(*共同通讯作者)
  9. Siqi Yao#, Lingping Tan#,  Huan Chen, Xiaojun Huang, Wei Zhao*, and Yan Wang*.Potential Research Tool Of Stem Cells From Human Exfoliated Deciduous Teeth: Lentiviral Bmi-1 Immortalization With EGFP Marker. Stem Cells International, 2019;3526409. (*通讯作者)
  10. Qianmin Ou#, Lingping Tan#, Xiaojun Huang, Qipei Luo, Yan Wang*,Xuefeng Lin*. Effect of matrix metalloproteinase 8 inhibitor and chlorhexidine on the cytotoxicity, oxidative stress and cytokine level of MDPC-23.Dent Materials. 2018;34(11):e301-e308.(2019IF 4.495) (*通讯作者)
  11. Qianmin Ou#, Ya Hu#, Siqi Yao, Yan Wang*, Xuefeng Lin*. Effect of matrix metalloproteinase 8 inhibitor on resin-dentin bonds. Dent Materials. 2018;34(5):756-763. (*通讯作者)
  12. Qianmin Ou#, Xiaoxiao Wang#,Yanlan Wang,Yan Wang*, Xuefeng Lin*.Oestrogen retains human periodontal ligament stem cells stemness in long-term culture. Cell Proliferation. 2018;51(2):e12396. ( *通讯作者)
  13. Yao S, Zhao W, Ou Q, Liang L, Lin X*, Wang Y*. MicroRNA-214 Suppresses Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Targeting ATF4. Stem Cells International. 2017;2017:3028647. ( *通讯作者)