高雳 | 中山大学附属口腔医院

高雳

主任医师硕士生导师

导师简介

【学位 / 学历】

博士/博士研究生

【学术简历】

2001.9-2006.6 天津医科大学口腔医学学士

2006.9-2009.6 四川大学口腔临床医学硕士

2009.9-2012.6 四川大学口腔临床医学博士

【研究方向】

1.牙周微生物免疫

2.牙周炎与全身疾病的关系

3.牙周微生态调控

【主持课题】

1.2022-2025 国家自然科学基金面上项目（82170959），55万元

2.2022-2024 广东省自然科学基金面上项目（2022A1515010855），10万元

3.2026-2028 广东省自然科学基金面上项目（2026A1515012883），10万元

【发表论文】

1.Ding J #, Tan L #, Wu L #, et al, Zhao C *, Gao L *. Regulation of tryptophan-indole metabolic pathway in Porphyromonas gingivalis virulence and microbiota dysbiosis in periodontitis. npj Biofilms Microbiomes. 2025, 11(1), 37.

2.Gao L＃, et al, Kapila YL*. Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome. npj Biofilms Microbiomes. 2022;8(1):45.

3.Zhang C#, Tan L#, et al, Gao L*, Zhao C*. REV-ERBα Inhibits Osteoclastogenesis and Protects against Alveolar Bone Loss. J Dent Res. 2025,104(2), 193–203.

4.Wu L#, Wu S#, Deng Y#, et al, Zhao C*, Gao L*. Indole-3-aldehyde preserves gingival epithelial barrier structure and function via AhR/Nrf2 signaling pathway. Inflammation. 2026, 49(1):33.

5.Ding J#, Li J#, et al, Zhao C*, Gao L*. High-Throughput Combined Analysis of Saliva Microbiota and Metabolomic Profile in Chinese Periodontitis Patients: A Pilot Study. Inflammation. 2024, 47(3):874-890.

6.Wu L#, Li X#, et al, Zhao C*, Gao L*. The role of aryl hydrocarbon receptor in the occurrence and development of periodontitis. Front Immunol. 2024, 15:1494570.

7.Huang Y＃, Zhang L＃, et al, Gao L*, Zhao C*. Interleukin-22 Inhibits Apoptosis of Gingival Epithelial Cells Through TGF-β Signaling Pathway During Periodontitis. Inflammation. 2023, Oct;46(5):1871-1886.

8.Yao J#， Zhang C#, Yu C#, et al, Li W*, Gao L*, Zhao C*. Immune microenvironment modulation for treating inflammatory periodontal bone defects using a dynamic dual-responsive hydrogel. J Mater Chem B. 2025，13(26), 7819–7837.

9.Huang P#, Gao L#, et al, Wang Y*, Yang B*. IL7-IL7R Interaction Mediates Fibroblast-Driven Macrophage-to-Osteoclast Differentiation in Periodontitis. J Inflamm Res. 2025, 18:6105-6122.

10.Gao L＃, Liu G＃, et al, Ma Y*, Hao Z*. Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading. Arch Biochem Biophys. 2023，742:109634.

11.Ding J＃, Zhao C*, Gao L*. Metabolism of periodontal pathobionts: Their regulatory roles in the dysbiotic microbiota. Mol Oral Microbiol. 2023，38(3):181-188.

12.Huang D#, et al, Gao L*, Zhao C*. JMJD3 Promotes Porphyromonas gingivalis Lipopolysaccharide-Induced Th17-Cell Differentiation by Modulating the STAT3-RORc Signaling Pathway. DNA Cell Biol. 2022，41(8):778-787.