高雳
副主任医师 硕士生导师
导师简介

学位 / 学历

博士 / 博士研究生

学术简历

2001.9-2006.6  天津医科大学口腔医学专业获学士学位

2006.9-2009.6  四川大学口腔临床医学专业获硕士学位

2009.9-2012.6  四川大学口腔临床医学专业获博士学位

研究方向

1. 牙周微生物免疫

2. 牙周炎与全身疾病的关系

3. 牙周微生态调控

主持课题

1. 2022-2025年:《牙周致病菌的色氨酸酶-吲哚代谢途径通过菌群-AhR轴调控微生态的作用及机制研究》,国家自然科学基金面上项目55万元

2. 2022-2024:《牙周菌群的色氨酸代谢产物通过芳烃受体调控牙龈上皮屏障的作用及机制研究》,广东省自然科学基金面上项目10万

发表论文

1. Ding J #, Tan L #, Wu L #, Li J, Zhang Y, Shen Z, Chi Zhang, Zhao C *, Gao L *. Regulation of tryptophan-indole metabolic pathway in Porphyromonas gingivalis virulence and microbiota dysbiosis in periodontitis. npj Biofilms Microbiomes.2025, 11(1), 37. (末位通讯, 中科院大类1区,IF:7.8)

2. Gao L#, Kuraji R, Zhang MJ, Martinez A, Radaic A, Kamarajan P, Le C, Zhan L, Ye C, Rangé H, Sailani MR, Kapila YL*. Nisin probiotic prevents inflammatory bone loss while promoting reparative proliferation and a healthy microbiome. NPJ Biofilms Microbiomes. 2022;8(1):45.(第一作者,中科院大类1区,IF:7.8)

3. Gao L#, Kang M, Zhang MJ, Reza Sailani M, Kuraji R, Martinez A, Ye C, Kamarajan P, Le C, Zhan L, Rangé H, Ho SP, Kapila YL*. Polymicrobial periodontal disease triggers a wide radius of effect and unique virome. NPJ Biofilms Microbiomes. 2020, 6(1):10. (第一作者,中科院大类1区,IF:7.8)

4. Zhang C#, Tan L#, Li J, Shen Z, Yao J, Huang Y, Wu L, Yu C, Gao L*, Zhao C*. REV-ERBα Inhibits Osteoclastogenesis and Protects against Alveolar Bone Loss. Journal of dental research,   2025,104(2), 193–203. (末二共通, 中科院大类1区,IF:5.7)

5. Ding J#, Li J#, Zhang C, Tan L, Zhao C*, Gao L*. High-Throughput Combined Analysis of Saliva Microbiota and Metabolomic Profile in Chinese Periodontitis Patients: A Pilot Study. Inflammation. 2024, 47(3):874-890. (末位通讯, 中科院大类2区,IF:4.5)

6. Wu L#, Li X#, Li J, Wang Y, Yang C, Zhao C*, Gao L*. The role of aryl hydrocarbon receptor in the occurrence and development of periodontitis. Front Immunol. 2024, 15:1494570. (末位通讯, 中科院大类2区,IF:5.7)

7. Zhao C#, Chen Q, Yu S, Xu C, Li X, Zhang C, Gao L*. Effect of interleukin-22 on osteogenic differentiation and the osteoclastogenic response of Human periodontal ligament fibroblasts in vitro. J Periodontol. 2020,91(8):1085–1097.(通讯作者,中科院大类2区,IF:4.2)

8. Huang Y#, Zhang L#, Tan L, Zhang C, Li X, Wang P, Gao L*, Zhao C*. Interleukin-22 Inhibits Apoptosis of Gingival Epithelial Cells Through TGF-β Signaling Pathway During Periodontitis. Inflammation. 2023, Oct;46(5):1871-1886. (末二共通, 中科院大类2区,IF:4.5)

9. Gao L#, Liu G#, Wu X, Liu C, Wang Y, Ma M, Ma Y*, Hao Z*. Osteocytes autopHagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading. Arch Biochem BiopHys. 2023,742:109634.(第一作者,中科院大类3区,IF:3.8)

10. Ding J#, Zhao C*, Gao L*. Metabolism of periodontal pathobionts: Their regulatory roles in the dysbiotic microbiota. Mol Oral Microbiol.  2023,38(3):181-188.(末位通讯,中科院大类3区,IF:2.8)

11. Huang D#, Zhang C, Wang P, Li X, Gao L*, Zhao C*. JMJD3 Promotes PorpHyromonas gingivalis Lipopolysaccharide-Induced Th17-Cell Differentiation by Modulating the STAT3-RORc Signaling Pathway. DNA Cell Biol. 2022,41(8):778-787.(末二共通,中科院大类4区,IF:2.6)

12. Gao L#, Ma Y, Li X, Zhang L, Zhang C, Chen Q, Zhao C*. Research on the roles of genes coding ATP-binding cassette transporters in Porphyromonas gingivalis pathogenicity. J Cell Biochem. 2020; 121(1):93-102. (第一作者,中科院大类3区,IF :3)

参编教材与论著

2023年9月  主编《光动力疗法的原理及其在口腔疾病治疗中的应用》 中国人口出版社

社会兼职

1. 中华口腔医学会牙周病学专业委员会委员

2. 广东省口腔医学会牙周病学专业委员会委员

联系方式

地址:广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院

电话:020-83742557

邮箱:gaol7@mail.sysu.edu.cn