【学位 / 学历】

博士 / 研究生

【学术简历】

2009.09-2014.06  中山大学口腔医学专业获本科学位

2014.07-2016.06  中山大学口腔医学专业获硕士学位

2016.09-2019.06  中山大学口腔临床医学专业获博士学位

【研究方向】

1. 口腔修复学

2. 口腔材料学

【主持课题】

1. 2024-2026年：《聚合物囊泡用于实现抗菌-免疫调控双功能改善牙周炎治疗效果的作用研究》，广州市科学技术局“启航”专项，5万

2. 2023-2025年：《FPHA抑制糖酵解调控巨噬细胞极化促进成骨的作用及机制研究》，广东省基础与应用基础研究基金委员会面上项目，10万

3. 2022-2023年：《ROS/Sirt1/HIF-1α介导的糖酵解减弱在FPHA抑制巨噬细胞M1极化促进骨缺损修复中的作用研究》，口腔疾病研究国家重点实验室开放课题，10万

4. 2021-2023年：《氟化猪骨源羟基磷灰石增强线粒体氧化磷酸化诱导巨噬细胞M2极化促进成骨的作用及机制》，国家自然科学基金青年科学基金，24万

5. 2020-2021年：《线粒体OXPHOS介导的巨噬细胞M2极化在FPHA促进BMSCs成骨中的作用及机制》，中国博士后科学基金面上项目，8万

6. 2020-2022年：《低pH/高ROS双响应纳米生物玻璃载甲氨蝶呤药物递释系统的构建及其抗口腔颌面恶性肿瘤活性的研究》，高校基本科研业务费中山大学青年教师培育项目，15万

【发表论文】

1.Pengjie Huang#, Li Gao#, Jiezhong Guan, Yijiao Li, Yibing Jia, Zixiang Zeng, Yurun Chen, Linge Wang, Weichang Li, Yan Wang*, Bo Yang*. IL7-IL7R Interaction Mediates Fibroblast-Driven Macrophage-to-Osteoclast Differentiation in Periodontitis. J Inflamm Res. 2025 May;18:6105-6122.

2.Pengjie Huang#, Weichang Li#, Jiezhong Guan, Yibing Jia, Dan Wang, Yurun Chen, Niu Xiao, Songyue Ou, Yan Wang*, Bo Yang*. Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions. J Funct Biomater. 2025 Jan; 16(1):25.

3.Weichang Li#, Yijiao Li#, Niu Xiao#, Manqing Liu, Deqian Tang, Songyue Ou, Li Gao, Changhao Li, Xiting Li, Yan Wang*, Bo Yang*. A promising platform of nanovesicles as a synergistic strategy for antibacterial and immunomodulation in treating periodontitis. Cell Rep Phys Sci. 2024 Sep; 5(9):102205.

4.Xuefei Pang#, Ling Li#, Xu Liu#, Yan Wang*, Bo Yang*. Application of Emerging Teaching Models in Dental Education: A Systematic Review and Meta-Analysis. Int Dent J. 2024 Dec;74(6):1185-1196.

5.Jiezhong Guan#, Xi Xu#, Guo Qiu#, Chong He#, Xiaoyue Lu, Kang Wang, Xinyu Liu, Yuanyuan Li, Zihang Ling, Xuan Tang, Yujie Liang, Xiaoan Tao*, Bin Cheng*, Bo Yang*. Cellular hierarchy framework based on single-cell/multi-patient sample sequencing reveals metabolic biomarker PYGL as a therapeutic target for HNSCC. J Exp Clin Cancer Res. 2023 Jul;42(1):162.

6.Jiezhong Guan, Xinyu Liu, Kang Wang, Yiqun Jia, Bo Yang*. Identification of a novel necroptosis-associated miRNA signature for predicting the prognosis in head and neck squamous cell carcinoma. Open Med (Wars). 2022 Oct;17(1):1682-1698.

7.Kaidi Chen#, Seongmin Ha#, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu*, Bo Yang*, Zhuofan Chen*. Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation. J Transl Med. 2024 May;22(1):437.

8.Bo Yang#, Xueling Li*, Yanshan Li, Ling Yang. Application of virtual technology to maximize esthetics and function in the restoration of anterior traumatic dental injuries. J Prosthet Dent. 2023 Oct:S0022-3913(23)00636-4.

9.Bo Yang#, Xuefei Pang#, Jiezhong Guan, Xu Liu, Xiting Li, Yan Wang*, Zhuofan Chen*, Bin Cheng*. The association of periodontal diseases and Sjogren's syndrome: A systematic review and meta-analysis. Front Med (Lausanne). 2023 Jan;9:904638.

10.Bo Yang, Wondwosen Aregawi, Ruoqiong Chen, Lin Zhang, Yan Wang*, Alex S L Fok*. Accelerated Fatigue Model for Predicting Composite Restoration Failure. J Dent Res. 2022 Dec;101(13):1606-1612.

11.Bo Yang#, Xuefei Pang#, Zhipeng Li*, Zhuofan Chen*, Yan Wang*. Immunomodulation in the treatment of periodontitis: progress and perspectives. Front Immunol. 2021 Nov;12:781378.

12.Tingting Zhang#, Bo Yang#, Ruihan Ge, Chaobiao Zhang, Hui Zhang*, Yan Wang*. Effect of a Novel 'Scan Body' on the In Vitro Scanning Accuracy of Full-Arch Implant Impressions. Int Dent J. 2024 Aug;74(4):847-854.

13.Zongtai Li#, Tao Yang#, Xiaolei Li#, Panchao Yin, Bo Yang, Dongying Li, Yan Wang*, Wei Teng*, Qianqian Yu*, Weichang Li*. A Bio-Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries. Adv Sci (Weinh). 2025 Apr:e2500088.

14.Chengwu Liu#, Leyao Xu#, Junming Feng#, Bo Yang, Kaidi Chen, Yuanxiang Liu, Xiayi Wu, Shiyu Wu, Zhipeng Li, Shoucheng Chen*, Zhuofan Chen*, Fluorine-Incorporated Biogenic Hydroxyapatite Enhances Socket Bone Healing via Addressing Macrophage-Mediated Inflammatory Response. Bioengineering (Basel). 2025 Apr;12(4):396.

15.Changhao Li, Siyu Zhang, Yichen Yao, Yanlan Wang, Cairong Xiao, Bo Yang, Jingyan Huang, Weichang Li, Chengyun Ning, Jinxia Zhai*, Peng Yu*, Yan Wang*. Piezoelectric bioactive glasses composite promotes angiogenesis by the synergistic effect of wireless electrical stimulation and active ions. Adv Healthc Mater. 2023 Feb;e2300064.

16.Yichen Lee#, Jingyan Huang#, Zhaoxia Bing, Kaiting Yuan, Jinghong Yang, Min Cai, Shiqi Zhou, Bo Yang, Wei Teng, Weichang Li*, Yan Wang*. pH-responsive cinnamaldehyde-TiO2 nanotube coating: fabrication and functions in a simulated diabetes condition. J Mater Sci Mater Med. 2022 Sep;33(9):63.

17.Min Cai#, Xiaojun Li#, Meng Xu, Shiqi Zhou, Lei Fan, Jingyan Huang, Cairong Xiao, Yichen Lee, Bo Yang, Le Wang, Ross William Crawford, Yin Xiao, Lei Zhou*, Chengyun Ning*, Yan Wang*. Injectable Tumor Microenvironment-Modulated Hydrogels with Enhanced Chemosensitivity and Osteogenesis for Tumor-Associated Bone Defects Closed-Loop Management. Chem Eng J. 2022 Jul; 450(8):138086

18.Hong Hong#, Xiaochuan Chen#, Kun Li, Nan Wang, Mengjie Li, Bo Yang, Xiaoqi Yu*, Xi Wei*. Dental follicle stem cells rescue the regenerative capacity of inflamed rat dental pulp through a paracrine pathway. Stem Cell Res Ther. 2020 Aug;11(1):333.

19.Jiawen Guo#, Bo Yang, Jiajun Yang, Brian Holmes, Alex Fok*, Jihua Chen*, Yan Wang*. Optical and mechanical factors in the temporal development of tooth-composite bond. Dent Mater. 2020 May;36(5):660-671.

【参编教材与论著】

1. 2024年 执行主编《中山大学医疗援助多米尼克纪实》中山大学出版社 987-7-306-08042-4

2. 2022年 主编《常见传染病校园防控手册》 中山大学出版社  

987-7-306-07525-3

  3. 2022年 参编《口腔修复学同步习题集》 人民卫生出版社 987-7-117-32476-2

【获奖及学术荣誉】

1. 2024 年 广东省柯麟医学教育基金会临床医学专业优秀中青年教师奖教金突出贡献奖

2. 2024 年 广东省医院协会医院管理与科技创新奖(科技类) 一等奖

3. 2024 年 广东省医院协会医院管理与科技创新奖(科技类) 二等奖

4. 2024 年 广东省健康科普大赛图文类三等奖

5. 2024 年 中山大学优秀班主任

6. 2023 年 全国高校教师教学创新大赛二等奖

7. 2023 年 新时代健康科普作品征集大赛入围奖

8. 2023 年 广东省健康科普大赛图文类一等奖

9. 2021 年 广东省科学就医公众宣教作品征集大赛图文类三等奖

【社会兼职】

1. 中华口腔医学会口腔材料专委会青年委员

2. 广东省精准医学应用学会口腔修复种植分会委员

3. 广东省整形美容协会口腔整形美容分会委员

【联系方式】

地址：广东省广州市越秀区陵园西路56号

邮箱：yangb86@mail.sysu.edu.cn