【学位 / 学历】

博士 / 博士研究生

【学术简历】

2004.09-2009.06  重庆医科大学口腔医学专业

2009.09-2012.06  四川大学口腔医学专业

2012.09-2015.06  四川大学口腔医学专业

【研究方向】

1.细胞外囊泡

2.神经化骨组织工程

3.细胞力学信号转导

【主持课题】

1. 2024年4月：《葡萄籽多酚包被机械加载的雪旺细胞外泌体通过 miR-9a-5p 调控牙周组织稳态促进牙周再生的研究》，口腔疾病防治全国重点实验室开放课题 ，10万

2. 2022年9月：《雪旺细胞外泌体通过miR-23a-3p靶向SOCS6调控骨微环境促进骨缺损修复的研究》，国家自然科学基金委 青年科学基金，30万

3. 2021年3月：《机械应力激活骨细胞自噬通过Leptin/JAK/STAT3信号通路调控骨改建的研究》，广东省基础与应用基础研究委员会 广东省自然科学基金-面上项目，10万

4. 2020年3月：《基于PI3K/AKT信号通路探讨机械应力作用下IL-6调控骨细胞自噬的研究》，广东省基础与应用基础研究委员会 区域联合基金-青年基金项目，10万

5. 2020年7月：《PI3K/AKT和ERK1/2信号通路crosstalk对机械应力下IL-6调控骨细胞凋亡的研究》，广东省卫生建设委员会 广东省医学科学技术研究基金项目，0.5万

【发表论文】

1. Merirui Ma #, Qianyi Wu#, Tianyou Wang#, Yuanyuan Ma, Le Fan , Yiqiao Wang , Liulin Jiang, Zhipeng Gu *, Zhichao Hao*. Therapeutic potential of extracellular vesicle-polyphenol nanoplatform in regenerative medicine. Nano Materials Science. Accept （IF=12.6，中科院大类1区）.

2. Yiqiao Wang#, Xiangnan Wu#, Jiawen Guo, Le Fan, Xiyun Zhang, Mingzhen Mo, Yu Zhao, Peiyan Zhou, Yuanyuan Ma*, Zhichao Hao*. Wear behavior and biological properties of 3D-printed zirconia by stereolithography apparatus after low temperature degradation. Ceramic International. 2025,51(9): 11702-11713.

3. Shujie Wu#, Tao Yang#, Meirui Ma, Le Fan, Lin Ren, Gen Li, Yiqiao Wang, Bin Cheng*, Juan Xia *, Zhichao Hao *. Extracellular vesicles meet mitochondria: Potential roles in regenerative medicine. Pharmacological Research. 2024，206:107307

4. Gen Liu#, Ling Yang#, Li Gao, Yuanyuan Ma, Xiangnan Wu, Xiaodong Wang, Zhichao Hao*. Durability of infiltrated resin application on white spot lesions after different challenges: An ex vivo study. The Journal of Prosthetic Dentistry. 2024,131(3):500-507.

5. Li Gao#,Gen Liu#,Xiangnan Wu, Chuanzi Liu, Yiqiao Wang, Meirui Ma, Yuanyuan Ma*, Zhichao Hao*. Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading. Archives of Biochemistry and Biophysics. 2023,742:109634.

6. Zhenzhen Wu, Le Fan, Cuiting Chen, Yuanyuan Ma, Xiangnan Wu, Ying Li*, Zhichao Hao*, Tao Yang*. Promotion of osteoporotic bone healing by a tannic acid modified strontium-doped biomimetic bone lamella with ROS scavenging capacity and pro-osteogenic effect. Smart Materials in Medicine,2023, 4: 590–602.

7. Xiangnan Wu#, Yiqiao Wang# , Hang Wang, Meirui Ma, Zhichao Hao* , Yuanyuan Ma*. Neuropeptide Y regulates osteocyte phenotype and function through AHNAK-Smad signal. Journal of Molecular Endocrinology. 2023,71(2):e230011.

8. Zhichao Hao#, Gen Liu#, Lin Ren#, Jiangchen Liu, Chuanzi Liu, Tao Yang, Xiangnan Wu, Xinchun Zhang, Ling Yang *, Juan Xia *, Weichang Li *. A self-healing multifunctional hydrogel system accelerates diabetic wound healing through orchestrating immunoinflammatory microenvironment. ACS Applied Materials & Interfaces. 2023,15(16):19847-19862.

9. Zhichao Hao#, Lin Ren#, Zhen Zhang#, Zaiwu Yang, Shujie Wu, Gen Liu, Bin Cheng*, Jun Wu*, Juan Xia*. A multifunctional neuromodulation platform utilizing Schwann cell-derived exosomes orchestrates bone microenvironment via immunomodulation, angiogenesis and osteogenesis. Bioactive Materials, 2023,23:206-222. (IF: 18，中科院大类1区，高被引文献)

10. Tao Yang #, Zhichao Hao #, Zhenzhen Wu #, Binxin Xu, Jiangchen Liu, Le Fan, Qinmei Wang, Yanshan Li, Dongying Li, Sangzhu Tang, Chuanzi Liu, Weichang Li *, Wei Teng *. An engineered lamellar bone mimicking full-scale hierarchical architecture for bone regeneration. Bioactive Materials. 2023,27:181-199. (IF: 18，中科院大类1区)

11. YiqiaoWang#, Ruizong Hui#, Li Gao, Yuanyuan Ma, Xiangnan Wu, Yukun Meng, Zhichao Hao*. Effect of surface treatments on bond durability of zirconia-reinforced lithium silicate ceramics: An in vitro study. The Journal of Prosthetic Dentistry. 2022,128(6):1350.e1-1350.e10.

12. Zhen Zhang#, Zhichao Hao#, Caihong Xian, Yifen Fang, Cheng Bin *, Jun Wu *, Juan Xia *. Neuro-bone tissue engineering: Multiple potential translational strategies between nerve and bone, Acta Biomaterialia. 2022,153:1-12. (IF: 9.4，中科院大类1区)

13. Ruixin Chen#, Zhichao Hao#, Xiaodan Chen, Qiang Fu*, Yuanyuan Ma*. Neuropeptide Y enhances proliferation and chondrogenic differentiation of ATDC5 cells. Neuropeptides. 2020,80:102022.

【参编教材与论著】

2021年 参编《口腔修复学精选习题集》 人民卫生出版社 9787117307970

【社会兼职】

1. 广东省生物医学工程会生物医用材料和临床应用分会长常委

2. 广东省自然医学研究会-干细胞与中医再生专委委员

【联系方式】

地址：越秀区陵园西路56号修复科

邮箱：haozhch3@mail.sysu.edu.cn