【学位 / 学历】

博士 / 博士研究生

【学术简历】

2000.07-2005.06  山西医科大学口腔医学专业获学士学位

2005.09-2008.06  中山大学口腔临床医学专业获硕士学位

2010.09-2013.06  中山大学口腔临床医学专业获博士学位

【研究方向】

1. 成骨/成牙本质分化

2. 牙髓牙本质复合体再生

3. 牙周炎发生发展机制

【主持课题】

2023.01-2025.12：《XBP1激活NLRP3炎症小体促进牙周炎进展的作用和机制》，广东省自然科学基金, 面上项目，10万

【发表论文】

1. Zhaocai Zhou; Chi Zhan; Wenchuan Li; Wenji Luo; Yufeng Liu; Feng He; Yaguang Tian; Zhengmei Lin; Zhi Song*; Monocytic myeloid-derived suppressor cells contribute to the exacerbation of bone destruction in periodontitis, Journal of Translational Medicine, 2025, 23(1): 217.

2. Jinyan Wu; Yaxian Huang; Chi Zhan; Lingling Chen; Zhengmei Lin; Zhi Song*; Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes, iScience,2023, 26(9): 107618.

3. Yaxian Huang; Jinyan Wu; Chi Zhan; Rong Liu; Zhaocai Zhou; Xin Huang; Yaguang Tian; Zhengmei Lin; Zhi Song*; TRAF-STOP alleviates osteoclastogenesis in periodontitis, Frontiers in pharmacology, 2023, 14: 1119847.

4. Feng He; Yanrui Huang; Zhi Song#; Huanjiao Jenny Zhou; Haifeng Zhan; Rachel J. Perry; Gerald I. Shulman; Wang Min; Mitophagy-mediated adipose inflammation contributes to type 2 diabetes with hepatic insulin resistance, JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 218(3).

5. Chi Zhan, Zhaocai Zhou, Yaxian Huang, Shuheng Huang, Zhengmei Lin, Feng He, Zhi Song*. Exploration of the shared gene signatures and molecular mechanisms between periodontitis and inflammatory bowel disease: evidence from transcriptome data. Gastroenterol Rep (Oxf). 2023 Jul 14;11:goad041.

6. Mengdi Li, Shuheng Huang, Yong Zhang, Zhi Song, Haijun Fu, Zhengmei Lin, Xin Huang. Regulation of the unfolded protein response transducer IRE1α by SERPINH1 aggravates periodontitis with diabetes mellitus via prolonged ER stress. Cell Signal. 2022 Mar; 91:110241

7. Mingmei Yang, Zongshan Shen, Xinfang Zhang, Zhi Song, Yong Zhang, Zhengmei Lin, Lingling Chen. Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway. Free Radic Biol Med. 2023 Nov 1;208:334-347.

【联系方式】

地址：广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院（510055）

电话：020-83861544

邮箱：492622865@qq.com