【学位 / 学历】

博士 / 博士研究生

【学术简历】

1995-2000 安徽医科大学口腔医学专业获学士学位

2005-2008 第四军医大学牙体牙髓病学硕士专业获学位学位

2009-2012 第四军医大学牙体牙髓病学专业获博士学位

【研究方向】

1. 单细胞转录组学

2. 根尖周炎和牙髓学免疫学机制

3. 口腔微生物

【主持课题】

1. 2025年：《ICAM1-PTGS2轴介导铁死亡调控巨噬细胞极化在根尖周炎中的作用机制研究》，广东省自然科学基金面上项目（2025A1515012566），10万

2. 2024年：《牙髓暂封膜在活体保髓中的应用》，中国高校产学研创新基金资助课题计划书2024GR116，5万

【发表论文】

1. Gong Qimei, Lv Xiaomin, Liao Chenxi, Liang Ailin, Luo Cuiting, Wu Jie, Zhou Yanling, Huang Yihua*, Tong Zhongchun*. Single-cell RNA sequencing combined with proteomics of infected macrophages reveals prothymosin-α as a target for treatment of apical periodontitis. Journal of Advanced Research. 2024;66:349-361. (中科院一区，IF: 11.4)

2. Tong Zhongchun#, Wu Jie#, Gong Qimei, Yuan Yifang, Wang Shengchao*, Jiang Wenkai*. Insulin-like growth factor binding protein 7 identified in aged dental pulp by single-cell RNA sequencing. Journal of Advanced Research. 2024. doi: 10.1016/j.jare.2024.12.018. Online ahead of print. (中科院一区，IF: 11.4)

3. Lv Xiaomin, Luo Cuiting, Wu Jie, Huang Yihua, Quan Jingjing, Gong Qimei*, Tong Zhongchun*. The integration of single-cell RNA sequencing of endothelial cells and proteomics unraveled the role of ICAM1–PTGS2 communication in apical periodontitis: A laboratory investigation. International Endodontic Journal. 2024;57(9):1228-1246. (中科院一区)

4. Lin Xinwei, Lv Xiaomin, Li Baoyu, Meng Qingzhen, Lai Hongbin, Gong Qimei*, Tong Zhongchun*. Heterogeneity of T cells in periapical lesions and in vitro validation of the proangiogenic effect of GZMA on HUVECs. International Endodontic Journal. 2023;56(10):1254-1269. (中科院一区)

5. Lai Hongbin, Lin Xinwei, Zhang Yuejiao, Gong Qimei, Tong Zhongchun*. Effect of different endodontic access preparations on the biomechanical behavior of lithium disilicate and resin nanoceramic onlay restorations: An in vitro and 3D finite element analysis study. Journal of Prosthetic Dentistry. 2024;131(1):64-74

6. Chi Danlu, Zhang Yuejiao, Lin Xingwei, Gong Qimei*, Tong Zhongchun*. Caspase-1 Inhibition Reduces Occurrence of PANoptosis in Macrophages Infected by E. faecalis OG1RF. Journal of Clinical Medicine. 2022;11(20):6204.

7. Lin Xinwei, Chi Danlu, Meng Qingzhen, Gong Qimei*, Tong Zhongchun*. Single-Cell Sequencing Unveils the Heterogeneity of Nonimmune Cells in Chronic Apical Periodontitis. Frontiers in Cell and Developmental Biology. 2022;9:820274. (中科院二区)

8. Gong Qimei, Huang Luo, Luo Junpan, Zhang Yuejiao, Meng Qingzhen, Quan Jingjing, Tong Zhongchun*. The practicability of different preparation of mandibular molar restored by modified endocrown with intracanal extension: Computational analysis using finite element models. Computer Methods and Programs in Biomedicine. 2022;226:107178. (中科院二区)

9. Zhang Yuejiao, Lai Hongbin, Meng Qingzhen, Gong Qimei, Tong Zhongchun*. The synergetic effect of pulp chamber extension depth and occlusal thickness on stress distribution of molar endocrowns: a 3-dimensional finite element analysis. Journal of Materials Science: Materials in Medicine. 2022 Jun 20;33(7):56

10. Lin Xinwei, Chi Danlu, Gong Qimei, Tong Zhongchun*. An in vitro study on the effects of serum proteins on Enterococcus faecalis adhesion to three types of root sealers and gutta-percha. BMC Oral Health. 2021;21(1):622 (中科院二区)

11. Meng Qingzhen, Zhang Yuejiao, Chi Danlu, Gong Qimei, Tong Zhongchun*. Resistance fracture of minimally prepared endocrowns made by three types of restorative materials: a 3D finite element analysis. Journal of Materials Science: Materials in Medicine. 2021;32(11):137.

12. Chi Danlu, Lin Xinwei, Meng Qingzhen, Tan Jiali, Gong Qimei, Tong Zhongchun*. Real-Time Induction of Macrophage Apoptosis, Pyroptosis, and Necroptosis by Enterococcus faecalis OG1RF and Two Root Canal Isolated Strains. Frontiers in Cellular and Infection Microbiology. 2021;11:720147. (中科院二区)

13. Chi Danlu, Zhang Yuejiao, Lin Xinwei, Tong Zhongchun*. Cyclic fatigue resistance for six types of nickel titanium instruments at artificial canals with different angles and radii of curvature. Dental Material Journal. 2021;40(5):1129-1135

【参编教材与论著】

1. 2025年 参编《显微牙髓治疗学》第二版 人民卫生出版社

2. 2025年 参编《口腔诊疗必备数字化技术全流程详解》 人民卫生出版社 

【联系方式】

地址：广州市越秀区陵园西路56号中山大学附属口腔医院牙体牙髓病科

邮箱：tongzhch@mail.sysu.edu.cn