李卫昌 | 中山大学附属口腔医院

李卫昌

副研究员硕士生导师

导师简介

【学位 / 学历】

博士 / 研究生

【学术简历】

2006.09-2010.06 周口师范学院化学专业获学士学位

2010.09-2013.06 暨南大学无机化学专业硕士学位

2014.09-2017.06 华南理工大学材料学专业博士学位

【研究方向】

1.组织修复与再生

2.生物材料

3.医用高分子

【主持课题】

1. 2020年：《刺激响应型生物粘合体系的制备和性能评价》，国家自然科学基金青年项目，25万

2. 2023年：《基于多模态抗菌-促矿化的新型树脂渗透陶瓷材料抗菌改性及其机制研究》，科学技术部国家重点研发计划，60万

3. 2023年：《智能响应粘合体系用于颌面部软组织损伤应急处理的关键技术研究》，广东省自然科学基金面上项目，10万

4. 2024年：《智能响应粘合体系用于颌面部软组织损伤应急处理的关键技术研究》，广东省自然科学基金青年提升项目，30万

5. 2020年：《响应型粘合体系的构建及对组织损伤应急处理的功能评价》，中国博士后科学基金面上项目，8万

【发表论文】

1.Xiaolei Li, Han Lin, Yilin Yu, Yukun Lu, Bin He, Meng Liu, Lin Zhuang, Yue Xu, Weichang Li*. In Situ Rapid‐Formation Sprayable Hydrogels for Challenging Tissue Injury Management. Advanced Materials, 2024, 36(19), 2400310.

2.Bowen Pang#, Weichang Li#, Jiaqin Li, Shangwu Yang, Taolin Sun, Qianqian Yu,* Kan Yue,* Wei Zhang.* A Microphase Separation‐Driven Supramolecular Tissue Adhesive with Instantaneous Dry/Wet Adhesion, Alcohol‐Triggered Debonding, and Antibacterial Hemostasis. Advanced Materials, 2025: 2501810.

3.Weichang Li, Xiaobo Liu, Zhishuang Deng, Yutong Chen, Qianqian Yu, Wen Tang, Tao Lin Sun, Yu Shrike Zhang, Kan Yue Tough Bonding, on-Demand Debonding, and Facile Rebonding between Hydrogels and Diverse Metal Surfaces. Advanced Materials, 2019,31,1904732.

4.Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li, Xinchun Zhang. In Situ Modulation of Dynamic Stiffness in Adaptive Hydrogel Systems for Enhanced Bone Defect Repair. Advanced Functional Materials. 2025, Accepted

5.Weichang Li, Shujie Wu, Lin Ren, Bingyu Feng, Zhipei Chen, Zongtai Li, Bin Cheng* Juan Xia*. Development of an Antiswelling Hydrogel System Incorporating M2-Exosomes and Photothermal Effect for Diabetic Wound Healing. ACS Nano. 2023, 17, 21, 22106–22120.

6.Zongtai Li, Tao Yang, Xiaolei Li, Panchao Yin, Bo Yang, Dongying Li, Yan Wang,* Wei Teng,* Qianqian Yu,* Weichang Li*. A Bio-Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries. Advanced Science, 2025, 2500088.

7.Guanming Cai, Lin Ren, Jiali Yu, Siqi Jiang, Gen Liu, Shujie Wu, Bin Cheng, Weichang Li, Juan Xia*. A Microenvironment‐Responsive, Controlled Release Hydrogel Delivering Embelin to Promote Bone Repair of Periodontitis via Anti‐Infection and Osteo‐Immune Modulation. Advanced Science, 2024, 11(34), 2403786.

8.Hui Chen, Zihan Li, Qianqian Yu, Weichang Li, Lisha Gu*. Antimicrobial and adhesive dendritic polymer coatings with real-time in situ monitoring via aggregation-induced emission. Advanced Composites and Hybrid Materials, 2025, 8(2), 1-15.

9.Tao Yang, Zhichao Hao, Zhenzhen Wu, Binxin Xu, Jiangchen Liu, Le Fan, Qinmei Wang, Yanshan Li, Dongying Li, Sangzhu Tang, Chuanzi Liu, Weichang Li, Wei Teng. An engineered lamellar bone mimicking full-scale hierarchical architecture for bone regeneration. Bioactive Materials, 2023, 27: 181-199.

10.Weichang Li, Mengjie Kong, Tao Yang, Jiaxin Li, Huaxiu Sun, Zongtai Li, Qinmei Wang, Wei Teng “one stone four birds” strategy of advanced hydrogel system based on eight-arm nanocages to promote chronic wound healing in diabetes Chemical Engineering Journal. 2023. 475. 146174.

11.Sishi Chen, Yang Qu, Zhuoran Wang, Yilin Zhang, Wenying Wang, Ruiyang Du, Weichang Li, Lisha Gu. Cerium oxide nanozymes-driven polyamine metabolic reprogramming for bone regeneration in high-fat environments. Chemical Engineering Journal, 2025, 164111.

12.Zhuoran Wang, Yilin Zhang, Sishi Chen, Yang Qu, Mengchen Tang, Wenying Wang, Weichang Li, Lisha Gu. Multifunctional CeO2 nanozymes for mitigating high-glucose induced senescence and enhancing bone regeneration in type 2 diabetes mellitus. Chemical Engineering Journal, 2024, 485, 149842.

13.Weichang Li, Laibo Jiang, Shujie Wu, Shiwen Yang, Lin Ren, Bin Cheng, Juan Xia. A shape-programmable hierarchical fibrous membrane composite system to promote wound healing in diabetic patients. Small, 2022:18(11) 2107544.

14.Zhichao Hao, Gen Liu, Lin Ren, Jiangchen Liu, Chuanzi Liu, Tao Yang, Xiangnan Wu, Xinchun Zhang, Ling Yang, Juan Xia, and Weichang Li*. A Self-Healing Multifunctional Hydrogel System Accelerates Diabetic Wound Healing through Orchestrating Immunoinflammatory Microenvironment. ACS Applied Materials & Interfaces, 2023. 15(16): 19847-19862.

15.Tingting Zhang, Jinghong Yang, Yu Lu, Yanlan Wang, Xiaoshuang Wang, Yijiao Li, Weichang Li, Yan Wang. Synergistic Functions of the Janus Fibrous Membrane for Enhanced Bone Repair. ACS Applied Materials & Interfaces, 2025, 17(10), 14873-14887.

16.Weichang Li, Yijiao Li, Niu Xiao, Manqing Liua, Deqian Tanga, Songyue Oua, Li Gaoa, Changhao Lia, Xiting Lia, Yan Wang, Bo Yang. A Promising Platform of Nano-vesicles as a Synergistic Strategy for Anti-bacterial and Immunomodulation in Treating Periodontitis. Cell Reports Physical Science. 2024. 5(9), 102205.

17.Jiufan Yao, Chi Zhang, Chuanying Yu, Lingzhi Wu, Lingping Tan, Weichang Li, Li Gao, Chuanjiang Zhao*. Immune Microenvironment Modulation for Treating Inflammatory Periodontal Bone Defects Using a Dynamic Dual-Responsive Hydrogel. Journal of Materials Chemistry B. 2025. DOI: 10.1039/D5TB00784D.

18.Jinghong Yang, Kaiting Yuan, Tingting Zhang, Shiqi Zhou, Weichang Li, Zetao Chen, Yan Wang*. Accelerated Bone Reconstruction by the Yoda1 Bilayer Membrane via Promotion of Osteointegration and Angiogenesis. Advanced Healthcare Materials, 2023: 2203105.

19.Xiaoqiong Huang, Lei Xu, Xiaoran Yu, Yiming Li, Ziqing Huang, Ruogu Xu, Wenyi Zeng, Zhengchuan Zhang, Weichang Li,* Feilong Deng.* Near-infrared light-responsive multifunctional hydrogel releasing peptide-functionalized gold nanorods sequentially for diabetic wound healing. Journal of Colloid and Interface Science, 2023, 639: 369-384.

20.Qiuxia Huang, Yang Qu, Mengchen Tang, Kaiwen Lan, Yilin Zhang, Sishi Chen, Weichang Li,*, Lisha Gu, ROS-responsive hydrogel for bone regeneration: Controlled dimethyl fumarate release to reduce inflammation and enhance osteogenesis. Acta Biomaterialia. 2025, 195(15), 183-200.

21.Jiaxin Li#, Weichang Li#, Mengjie Kong, Zongtai Li, Tao Yang, Qinmei Wang, Wei Teng. Self-healing hybrid hydrogels with sustained bioactive components release for guided bone regeneration. Journal of Nanobiotechnology, 2023, 21(1): 1-20.

22.Rui Yuan, Yuwen Zhang, Liqiong Liao, Yige Ge, Weichang Li, Qinghui Zhi. Biomineralization-Inspired Anti-Caries Strategy Based on Multifunctional Nanogels as Mineral Feedstock Carriers. International Journal of Nanomedicine, 2023: 4933-4947.

23.Peiyi Li, Yanfei Li, Tszyung Kwok, Tao Yang, Cong Liu, Weichang Li, Xinchun Zhang. A bi-layered membrane with micro-nano bioactive glass for guided bone regeneration. Colloids and Surfaces B: Biointerfaces, 2021, 205: 111886.

24.Yichen Lee, Jingyan Huang, Zhaoxia Bing, Kaiting Yuan, Jinghong Yang, Min Cai, Shiqi Zhou, Bo Yang, Wei Teng, Weichang Li, Yan Wang. pH-responsive cinnamaldehyde-TiO2 nanotube coating: fabrication and functions in a simulated diabetes condition. Journal of Materials Science: Materials in Medicine, 2022, 33(9): 1-14.

25.Pengjie Huang#, Weichang Li#, Jiezhong Guan, Yibing Jia, Dan Wang, Yurun Chen, Niu Xiao, Songyue Ou, Yan Wang, Bo Yang. Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions. Journal of Functional Biomaterials, 2025, 16(1), 25.

【参编教材与论著】

2021年参编《新型材料科学与技术》华南理工大学出版社 978-7-5623-6488-7

【社会兼职】

1. 中华口腔医学会/口腔材料专委会委员

2. Medmat青年编委

【联系方式】

地址：广东省广州市越秀区中山二路74号中山大学北校区

电话：020-83865065

邮箱：liwch57@mail.sysu.edu.cn

【研究方向】

1.组织修复与再生

2.生物材料

3.医用高分子

【主持课题】

【发表论文】

1.Xiaolei Li, Han Lin, Yilin Yu, Yukun Lu, Bin He, Meng Liu, Lin Zhuang*, Yue Xu*, Weichang Li*. In Situ Rapid‐Formation Sprayable Hydrogels for Challenging Tissue Injury Management. Advanced Materials, 2024, 36(19), 2400310.

2.Bowen Pang#, Weichang Li#, Jiaqin Li, Shangwu Yang, Taolin Sun, Qianqian Yu,* Kan Yue,* Wei Zhang.* A Microphase Separation‐Driven Supramolecular Tissue Adhesive with Instantaneous Dry/Wet Adhesion, Alcohol‐Triggered Debonding, and Antibacterial Hemostasis. Advanced Materials, 2025: 2501810.

3.Weichang Li, Xiaobo Liu, Zhishuang Deng, Yutong Chen, Qianqian Yu, Wen Tang, Tao Lin Sun, Yu Shrike Zhang*, Kan Yue* Tough Bonding, on-Demand Debonding, and Facile Rebonding between Hydrogels and Diverse Metal Surfaces. Advanced Materials, 2019,31,1904732.

4.Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li*, Xinchun Zhang*. In Situ Modulation of Dynamic Stiffness in Adaptive Hydrogel Systems for Enhanced Bone Defect Repair. Advanced Functional Materials. 2025, Accepted

5.Weichang Li, Shujie Wu, Lin Ren, Bingyu Feng, Zhipei Chen, Zongtai Li, Bin Cheng* Juan Xia*. Development of an Antiswelling Hydrogel System Incorporating M2-Exosomes and Photothermal Effect for Diabetic Wound Healing. ACS Nano. 2023, 17, 21, 22106–22120.

6.Zongtai Li, Tao Yang, Xiaolei Li, Panchao Yin, Bo Yang, Dongying Li, Yan Wang,* Wei Teng,* Qianqian Yu,* Weichang Li*. A Bio-Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries. Advanced Science, 2025, 2500088.

8.Hui Chen, Zihan Li, Qianqian Yu*, Weichang Li*, Lisha Gu*. Antimicrobial and adhesive dendritic polymer coatings with real-time in situ monitoring via aggregation-induced emission. Advanced Composites and Hybrid Materials, 2025, 8(2), 1-15.

9.Tao Yang, Zhichao Hao, Zhenzhen Wu, Binxin Xu, Jiangchen Liu, Le Fan, Qinmei Wang, Yanshan Li, Dongying Li, Sangzhu Tang, Chuanzi Liu, Weichang Li*, Wei Teng*. An engineered lamellar bone mimicking full-scale hierarchical architecture for bone regeneration. Bioactive Materials, 2023, 27: 181-199.

10.Weichang Li, Mengjie Kong, Tao Yang, Jiaxin Li, Huaxiu Sun, Zongtai Li, Qinmei Wang*, Wei Teng *“one stone four birds” strategy of advanced hydrogel system based on eight-arm nanocages to promote chronic wound healing in diabetes Chemical Engineering Journal. 2023. 475. 146174.

11.Sishi Chen, Yang Qu, Zhuoran Wang, Yilin Zhang, Wenying Wang, Ruiyang Du, Weichang Li*, Lisha Gu*. Cerium oxide nanozymes-driven polyamine metabolic reprogramming for bone regeneration in high-fat environments. Chemical Engineering Journal, 2025, 164111.

12.Zhuoran Wang, Yilin Zhang, Sishi Chen, Yang Qu, Mengchen Tang, Wenying Wang, Weichang Li*, Lisha Gu*. Multifunctional CeO2 nanozymes for mitigating high-glucose induced senescence and enhancing bone regeneration in type 2 diabetes mellitus. Chemical Engineering Journal, 2024, 485, 149842.

13.Weichang Li, Laibo Jiang, Shujie Wu, Shiwen Yang, Lin Ren, Bin Cheng*, Juan Xia*. A shape-programmable hierarchical fibrous membrane composite system to promote wound healing in diabetic patients. Small, 2022:18(11) 2107544.

15.Tingting Zhang, Jinghong Yang, Yu Lu, Yanlan Wang, Xiaoshuang Wang, Yijiao Li, Weichang Li*, Yan Wang*. Synergistic Functions of the Janus Fibrous Membrane for Enhanced Bone Repair. ACS Applied Materials & Interfaces, 2025, 17(10), 14873-14887.

17.Jiufan Yao, Chi Zhang, Chuanying Yu, Lingzhi Wu, Lingping Tan, Weichang Li*, Li Gao*, Chuanjiang Zhao*. Immune Microenvironment Modulation for Treating Inflammatory Periodontal Bone Defects Using a Dynamic Dual-Responsive Hydrogel. Journal of Materials Chemistry B. 2025. DOI: 10.1039/D5TB00784D.

18.Jinghong Yang, Kaiting Yuan, Tingting Zhang, Shiqi Zhou, Weichang Li*, Zetao Chen*, Yan Wang*. Accelerated Bone Reconstruction by the Yoda1 Bilayer Membrane via Promotion of Osteointegration and Angiogenesis. Advanced Healthcare Materials, 2023: 2203105.