职称/导师类型

研究员  博士生导师  硕士生导师

【学位/学历】

博士研究生

【学术简历】

2006.09-2010.06  周口师范学院化学专业获学士学位

2010.09-2013.06  暨南大学无机化学专业获硕士学位

2014.09-2017.06  华南理工大学材料学专业获博士学位

【研究方向】

1.组织修复与再生医学

2.生物医用材料

【主持课题】

1.2026年，国家自然科学基金面上项目，多重动态化学键分级调控的智能水凝胶用于糖尿病创面治疗研究，50万元

2.2020年，国家自然科学基金青年项目，刺激响应型生物粘合体系的制备和性能评价，25万元

3.2020年，国家自然科学基金青年项目，刺激响应型生物粘合体系的制备和性能评价，25万元

4.2023年，科学技术部国家重点研发计划，基于多模态抗菌-促矿化的新型树脂渗透陶瓷材料抗菌改性及其机制研究，60万元

5.2023年，广东省自然科学基金面上项目，智能响应粘合体系用于颌面部软组织损伤应急处理的关键技术研究，10万元

【发表论文】

1. Weichang Li, Chen Lili*. Bridging crystallinity and softness: dynamic coordination and functional integration in MOF–hydrogel hybrid materials. Progress in Materials Science, 2026, 101784.
2. Xiaolei Li, Han Lin, Yilin Yu, Yukun Lu, Bin He, Meng Liu, Lin Zhuang*, Yue Xu*, Weichang Li*. In Situ Rapid‐Formation Sprayable Hydrogels for Challenging Tissue Injury Management. Advanced Materials, 2024, 36(19), 2400310.
3. Bowen Pang#, Weichang Li#, Jiaqin Li, Shangwu Yang, Taolin Sun, Qianqian Yu,* Kan Yue,* Wei Zhang.* A Microphase Separation‐Driven Supramolecular Tissue Adhesive with Instantaneous Dry/Wet Adhesion, Alcohol‐Triggered Debonding, and Antibacterial Hemostasis. Advanced Materials, 2025: 2501810.
4. Weichang Li, Xiaobo Liu, Zhishuang Deng, Yutong Chen, Qianqian Yu, Wen Tang, Tao Lin Sun, Yu Shrike Zhang*, Kan Yue* Tough Bonding, on-Demand Debonding, and Facile Rebonding between Hydrogels and Diverse Metal Surfaces. Advanced Materials, 2019,31,1904732.
5. Meng Zhang, Silin Ye, Weichang Li*, Xinchun Zhang*, Lin Wang*. Bioorthogonal Anchor-and-Lock of Probiotic Biofilms on Diverse Biomaterials to Combat Delayed Implant-Associated Infection. Advanced Materials, 2026. e74083.
6. Yuxin Yang, Fan Yang, Lu Wang, Zongtai Li, Weichang Li*, Xinchun Zhang*. In Situ Modulation of Dynamic Stiffness in Adaptive Hydrogel Systems for Enhanced Bone Defect Repair. Advanced Science. 2026, e76920.
7. Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li*; Yunhua Chen*, Qiong Xu*. Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis. Advanced Science, 2026. e75497
8. Zongtai Li, Tao Yang, Xiaolei Li, Panchao Yin, Bo Yang, Dongying Li, Yan Wang,* Wei Teng,* Qianqian Yu,* Weichang Li*. A Bio-Responsive Hydrogel with Spatially Heterogeneous Structure for Treating Infectious Tissue Injuries. Advanced Science, 2025, 2500088.
9. Guanming Cai, Lin Ren, Jiali Yu, Siqi Jiang, Gen Liu, Shujie Wu, Bin Cheng*, Weichang Li*, Juan Xia*. A Microenvironment‐Responsive, Controlled Release Hydrogel Delivering Embelin to Promote Bone Repair of Periodontitis via Anti‐Infection and Osteo‐Immune Modulation. Advanced Science, 2024, 11(34), 2403786.
10. Weichang Li, Shujie Wu, Lin Ren, Bingyu Feng, Zhipei Chen, Zongtai Li, Bin Cheng* Juan Xia*. Development of an Antiswelling Hydrogel System Incorporating M2-Exosomes and Photothermal Effect for Diabetic Wound Healing. ACS Nano. 2023, 17, 21, 22106–22120.
11. Hui Chen, Zihan Li, Qianqian Yu*, Weichang Li*, Lisha Gu*. Antimicrobial and adhesive dendritic polymer coatings with real-time in situ monitoring via aggregation-induced emission. Advanced Composites and Hybrid Materials, 2025, 8(2), 1-15.
12. Tao Yang, Zhichao Hao, Zhenzhen Wu, Binxin Xu, Jiangchen Liu, Le Fan, Qinmei Wang, Yanshan Li, Dongying Li, Sangzhu Tang, Chuanzi Liu, Weichang Li*, Wei Teng*. An engineered lamellar bone mimicking full-scale hierarchical architecture for bone regeneration. Bioactive Materials, 2023, 27: 181-199.
13. Zequn Lin, Fangrong Tan, Zhanglu Lei, Yangtian Bian, Hongtao Qi, Weichang Li*, Qianqian Yu*. A cascade-responsive fibrous platform combining nanozyme and NO donor therapy for infected diabetic wound healing. Chemical Engineering Journal, 2026, 530(15), 173230.
14. Weichang Li, Mengjie Kong, Tao Yang, Jiaxin Li, Huaxiu Sun, Zongtai Li, Qinmei Wang*, Wei Teng *“one stone four birds” strategy of advanced hydrogel system based on eight-arm nanocages to promote chronic wound healing in diabetes Chemical Engineering Journal. 2023. 475. 146174.
15. Sishi Chen, Yang Qu, Zhuoran Wang, Yilin Zhang, Wenying Wang, Ruiyang Du, Weichang Li*, Lisha Gu*. Cerium oxide nanozymes-driven polyamine metabolic reprogramming for bone regeneration in high-fat environments. Chemical Engineering Journal, 2025, 164111.
16. Zhuoran Wang, Yilin Zhang, Sishi Chen, Yang Qu, Mengchen Tang, Wenying Wang, Weichang Li*, Lisha Gu*. Multifunctional CeO2 nanozymes for mitigating high-glucose induced senescence and enhancing bone regeneration in type 2 diabetes mellitus. Chemical Engineering Journal, 2024, 485, 149842.
17. Weichang Li, Laibo Jiang, Shujie Wu, Shiwen Yang, Lin Ren, Bin Cheng*, Juan Xia*. A shape-programmable hierarchical fibrous membrane composite system to promote wound healing in diabetic patients. Small, 2022:18(11) 2107544.
18. Jingyan Huang, Dongheng Lu, Yixuan Liu, Taras Vladimirovich Furtsev, Peng Yu, Chenye Hou, Xiaoshuang Wang, Weichang Li*, Yan Wang*. Advances in osteogenic niche engineering: integrating topography and electrical cues for bone repair and regeneration. Journal of Nanobiotechnology, 2026.
19. Jinghong Yang, Runli Li, Xiaoshuang Wang, Dongheng Lu, Weichang Li*, Yan Wang*. Mechanically tunable fiber-based hydrogel activates PIEZO1–integrin axis for enhanced bone repair. Journal of Nanobiotechnology. 2025, 23(1), 603.
20. Jiaxin Li#, Weichang Li#, Mengjie Kong, Zongtai Li, Tao Yang, Qinmei Wang*, Wei Teng*. Self-healing hybrid hydrogels with sustained bioactive components release for guided bone regeneration. Journal of Nanobiotechnology, 2023, 21(1), 1-20.
21. Zhichao Hao, Gen Liu, Lin Ren, Jiangchen Liu, Chuanzi Liu, Tao Yang, Xiangnan Wu, Xinchun Zhang, Ling Yang*, Juan Xia*, and Weichang Li*. A Self-Healing Multifunctional Hydrogel System Accelerates Diabetic Wound Healing through Orchestrating Immunoinflammatory Microenvironment. ACS Applied Materials & Interfaces, 2023. 15(16): 19847-19862.
22. Tingting Zhang, Jinghong Yang, Yu Lu, Yanlan Wang, Xiaoshuang Wang, Yijiao Li, Weichang Li*, Yan Wang*. Synergistic Functions of the Janus Fibrous Membrane for Enhanced Bone Repair. ACS Applied Materials & Interfaces, 2025, 17(10), 14873-14887.
23. Weichang Li, Yijiao Li, Niu Xiao, Manqing Liua, Deqian Tanga, Songyue Oua, Li Gaoa, Changhao Lia, Xiting Lia, Yan Wang, Bo Yang. A Promising Platform of Nano-vesicles as a Synergistic Strategy for Anti-bacterial and Immunomodulation in Treating Periodontitis. Cell Reports Physical Science. 2024. 5(9), 102205.
24. Han Lin, Jingyan Huang, Xiaoqi Xie, Qianqian Yu, Weicai Wang*, Weichang Li*, A pH-Responsive Nanozyme-Integrated Fibrous Biointerface for Chemodynamic Antibacterial Therapy and Infected Wound Healing. Colloids and Surfaces B: Biointerfaces, 2026.
25. Jiufan Yao, Chi Zhang, Chuanying Yu, Lingzhi Wu, Lingping Tan, Weichang Li*, Li Gao*, Chuanjiang Zhao*. Immune Microenvironment Modulation for Treating Inflammatory Periodontal Bone Defects Using a Dynamic Dual-Responsive Hydrogel. Journal of Materials Chemistry B. 2025. 13(26), 7819-7837.
26. Jinghong Yang, Kaiting Yuan, Tingting Zhang, Shiqi Zhou, Weichang Li*, Zetao Chen*, Yan Wang*. Accelerated Bone Reconstruction by the Yoda1 Bilayer Membrane via Promotion of Osteointegration and Angiogenesis. Advanced Healthcare Materials, 2023: 2203105.
27. Xiaoqiong Huang, Lei Xu, Xiaoran Yu, Yiming Li, Ziqing Huang, Ruogu Xu, Wenyi Zeng, Zhengchuan Zhang, Weichang Li,* Feilong Deng.* Near-infrared light-responsive multifunctional hydrogel releasing peptide-functionalized gold nanorods sequentially for diabetic wound healing. Journal of Colloid and Interface Science, 2023, 639: 369-384.
28. Qiuxia Huang, Yang Qu, Mengchen Tang, Kaiwen Lan, Yilin Zhang, Sishi Chen, Weichang Li,*, Lisha Gu, ROS-responsive hydrogel for bone regeneration: Controlled dimethyl fumarate release to reduce inflammation and enhance osteogenesis. Acta Biomaterialia. 2025, 195(15), 183-200.
29. Rui Yuan, Yuwen Zhang, Liqiong Liao, Yige Ge, Weichang Li*, Qinghui Zhi*. Biomineralization-Inspired Anti-Caries Strategy Based on Multifunctional Nanogels as Mineral Feedstock Carriers. International Journal of Nanomedicine, 2023: 4933-4947.
30. Peiyi Li, Yanfei Li, Tszyung Kwok, Tao Yang, Cong Liu, Weichang Li*, Xinchun Zhang*. A bi-layered membrane with micro-nano bioactive glass for guided bone regeneration. Colloids and Surfaces B: Biointerfaces, 2021, 205: 111886.
31. Yichen Lee, Jingyan Huang, Zhaoxia Bing, Kaiting Yuan, Jinghong Yang, Min Cai, Shiqi Zhou, Bo Yang, Wei Teng, Weichang Li*, Yan Wang*. pH-responsive cinnamaldehyde-TiO2 nanotube coating: fabrication and functions in a simulated diabetes condition. Journal of Materials Science: Materials in Medicine, 2022, 33(9): 1-14.
32. Pengjie Huang#, Weichang Li#, Jiezhong Guan, Yibing Jia, Dan Wang, Yurun Chen, Niu Xiao, Songyue Ou, Yan Wang*, Bo Yang*. Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions. Journal of Functional Biomaterials, 2025, 16(1), 25.

【近五年参编教材与论著】

（格式：1.主编/副主编/参编，书名，出版社，出版年月，ISBN）

1.参编，新型材料科学与技术，华南理工大学出版社，2021，978-7-5623-6488-7

【社会兼职】

1. 中华口腔医学会口腔材料专委会委员
2. 新质力材料发展联盟常务理事
3. 国际健康纤维电子前沿技术及应用会学术委员
4. 中西部地区生物制造及材料发展论坛组织委员
5. Medmat青年编委
6. Nano-Micro Letters (IF=36.3)青年编委
7. Regenerative Biomaterials (IF=8.1)青年编委
8. Interdisciplinary Medicine (IF = 13.6)青年编委

【联系方式】

地址：广东省广州市越秀区中山二路74号中山大学北校区

电话：020-83865065

邮箱：liwch57@mail.sysu.edu.cn