【学位 / 学历】

博士 / 博士研究生

【学术简历】

2009.09-2014.06 中山大学口腔医学专业获学士学位

2014.09-2019.06 中山大学口腔临床医学专业获博士学位

【研究方向】

1. 口腔种植相关生物材料

2. 精准种植

【主持课题】

1. 2024年：《基于靶向调控巨噬细胞磷脂酰丝氨酸外翻的IL-4/EGTA-MSNs胶原膜涂层研发》，广东省自然科学基金-面上项目，15万

2. 2023年：《BAPTA-MSNs/IL4水凝胶涂层靶向调控巨噬细胞磷脂酰丝氨酸外翻强化胶原膜屏障功能的研究》，国家自然科学基金青年项目，30万

3. 2022年：《通过靶向调控IL-13的聚多巴胺涂层调节屏障胶原膜降解性能的体内外及机制研究》，广东省基础与应用基础研究基金委，区域联合基金青年基金项目，10万

4. 2020年：《应用免疫调节策略实现屏障胶原膜的个性化降解调控》，中国博士后科学基金面上资助，8万

【发表论文】

1. Runheng Liu#, Shoucheng Chen#, Peina Huang, Guanqi Liu, Pu Luo, Zhipeng Li, Yin Xiao, Zhuofan Chen*, Zetao Chen*. Immunomodulation-based strategy for improving soft tissue and metal implant integration and its implications in the development of metal soft tissue materials. Advanced Functional Materials, 2020, 30, 21, 1910672.

2.Fang Jinghan#, Runheng Liu#, Shoucheng Chen, Quan Liu, Huaxiong Cai, Yixiong Lin, Zetao Chen*, Zhuofan Chen*. Tuning the immune reaction to manipulate the cell-mediated degradation of a collagen barrier membrane, Acta Biomaterialia, 2020, 109, 95-108.

3.Guanqi Liu#, Xuan Zhou#, Linjun Zhang#, Yang Zou, Junlong Xue, Ruidi Xia, Nuerbiya Abuduxiku, Xuejing Gan, Runheng Liu, Zhuofan Chen*, Yang Cao*, Zetao Chen*. Cell-free immunomodulatory biomaterials mediated in situ periodontalmulti-tissue regeneration and their immunopathophysiological processes. Materials today bio. 2022, 16, 100432.

4.You Wu#, Shoucheng Chen#, Pu Luo#, Shudan Deng, Zhengjie Shan, Jinghan Fang, Xingchen Liu, Jiaxin Xie, Runheng Liu, Shiyu Wu, Xiayi Wu, Zetao Chen, Kelvin W.K. Yeung∗, Quan Liu∗, Zhuofan Chen∗. Optimizing the bio-degradability and biocompatibility of a biogenic collagen membrane through cross-linking and zinc-doped hydroxyapatite. Acta Biomaterialia, 2022, 143, 159-172.

5.Shoucheng Chen#, Zhuwei Huang#, Rahul Madathiparambil Visalakshan, Haiwen Liu, Akash Bachhuka, You Wu, Panthihage Ruvini L Dabare, Pu Luo, Runheng Liu, Zhuohong Gong, Yin Xiao, Krasimir Vasilev*, Zhuofan Chen*, Zetao Chen*. Plasma polymerized bio-interface directs fibronectin adsorption and functionalization to enhance “epithelial barrier structure”formation via FN-ITGβ1-FAK-mTOR signaling cascade. Biomaterials research. 2022, 26, 88.

6.Quan Liu, Yuanxiang Liu, Danying Chen, Xiayi Wu, Ruoxuan Huang, Runheng Liu, Zetao Chen, Zhuofan Chen*. Placement accuracy and primary stability of implants in the esthetic zone using dynamic and static computer-assisted navigation: A retrospective case-control study. The Journal of prosthetic dentistry. 2024, 131, 3, 427-435.

7.Runheng Liu#, Ruidi Xia#, Linjun Zhang#, Xuejing Gan, Cuijun Li, Quan Liu, Zhuofan Chen, Zetao Chen*. The influence of guide stabilizers and their application sequences on trueness and precision of surgical guides in free end situations: An in vitro analysis. Clinical oral implants research. 2024, 35, 3, 294-304.

8.Xinchen Liu#, Shudang Deng#, Xiyan Li#, Haiwen Liu, Zhixin Li, You Wu, Pu Luo, Xinyi Zhong, Ruoxuan Huang, Runheng Liu, Xiayi Wu, Baoxin Huang, Zetao Chen*, Zhuofan Chen*. Shoucheng Chen*. A Standardized Rat Model to Study Peri-implantitis of Transmucosal Osseointegrated Implants. Biomaterials research. 2024, 28, 0021.

9.Mengru Shi#, Zhuohong Gong#, Peisheng Zeng#, Dawei Xiang, Gengbin Cai, Hengyi Liu, Shijie Chen, Runheng Liu, Zhuofan Chen*, Xinchun  Zhang*, Zetao  Chen*. Multi-Quantifying Maxillofacial Traits via a Demographic Parity-Based AI Model. BMEF, 2024,13:5:0054.

10.Guanqi Liu, Runheng Liu*. Maxillary Immediate Molar Implant Placement into Palatal Root Socket: A Case Report of 2 Year Follow Up. Cureus Journal of Medical Science, 2024,9;16(10):e71152.

11.Xiayi Wu, Chunxin Xu, Junming Feng, Shiyu Wu, Runheng Liu, Wei Qiao, Xin Luo, Shoucheng Chen, Zhipeng Li , Zhuofan Chen. Fluorinated Porcine Bone-Derived Hydroxyapatite Promotes Vascularized Osteogenesis by Coordinating Human Bone Marrow Mesenchymal Stem CellHuman Umbilical Vein Endothelial Cell Complexes. Bioengineering, 2024, 11, 1287. 1-22.

12.Xiongjun Xu, Junming Feng, Tianze Lin, Runheng Liu*, Zhuofan Chen*. miR-181a/MSC-Loaded Nano-Hydroxyapatite/Collagen Accelerated Bone Defect Repair in Rats by Targeting Ferroptosis Pathway. Journal of Functional Materials, 2024, 15(12), 385.

13.Guanqi Liu, Jiahui Lin, Xiaoyan Chen, Runheng Liu*, Gingival Fibroblast Suppress the Osteogenesis Process Mediated by Bone Substitute Materials via WNT/β-catenin Signaling Pathway in vitro and in vivo. Frontiers in Bioengineering and Biotechnology, 2025, 13:1521134.

14.Guanqi Liu#, Shudan Deng#, Runzhong Liu, Yuanxiang Liu, Quan Liu, Shiyu Wu, Zhuofan Chen*, Runheng Liu*, Precise multi-factor immediate implant placement decision models based on machine learning. Scientific Reports. 2025, 15:5143.

15.Guanqi Liu#, Shudan Deng#, Jiahui Lin, Xiaoyan Chen, Runheng Liu*, Biomechanical analysis of maxillary posterior three unit bridge supported misial straight implant and distal tilted implant. Frontiers in Bioengineering and Biotechnology. 2025, 13:1546656.

16.李志鹏, 刘远翔, 黄若萱, 刘成武, 刘润恒, 刘泉, 黄宝鑫, 陈泽涛, 陈卓凡*. 氟化猪骨羟基磷灰石修复犬植体周骨缺损的显微CT与组织形态学评价[J]. 中华口腔医学杂志, 2020, 55(11):908-914.

【参编教材与论著】

1. 2023年 参编《中国口腔种植临床精萃2023年卷》 辽宁科学技术出版社 978-7-5591-2890-4 

2. 2024年 参编《单颗后牙种植修复决策路径及操作实践》 人民卫生出版社 978-7-1173-6825-4

【获奖及学术荣誉】

2020年 2020年中华口腔医学会口腔医学科研管理分会第五次学术年会青年科学家论坛“最具风采”报告

【社会兼职】

1. 广东省口腔急诊专委会委员

2. 中华口腔医学会口腔生物医学专业委员会青年委员

3. 广东省口腔种植专委会青年委员青年委员

【联系方式】

地址：广州市越秀区陵园西路56号

电话：020-38092041

邮箱：liurh28@mail.sysu.edu.cn