【学位 / 学历】

博士 / 博士研究生

【学术简历】

2009.09-2014.06 中山大学口腔医学专业获学士学位

2014.08-2017.06 中山大学口腔临床医学专业获硕士学位

2017.09-2020.06 中山大学口腔基础医学专业获博士学位

【研究方向】

1.牙周组织的重建与再生

2.口腔生物材料

3.口腔正畸学

【主持课题】

1. 2025.01.01-2027.12.31：《FA-Mg-MSNs靶向调控巨噬细胞线粒体-内质网触点重塑衰老微环境促进牙周再生的研究》，广东省自然科学基金-面上项目 ，10万

2. 2023.01.01- 2025.12.31：《叶酸修饰的Mg-MSNs靶向调控巨噬细胞线粒体功能稳态促进牙周复合体再生的研究》，国自然青年项目，30万元

3. 2020.10-2023.09：《基于免疫微环境调控牙周多组织再生的镁基纳米支架的研发及机制研究》 ，广东省基础与应用基础研究：区域联合基金-青年基金项目 ，10万

4. 2020.10-2022.06：《基于免疫微环境调控促进牙槽骨-牙周纤维-牙骨质复合体再生的研究》，中国博士后科学基金面上项目，12万

【发表论文】

1.Guanqi Liu#, Junlong Xue#, Xuan Zhou#, Mixiao Gui, Ruidi Xia, Yanshu Zhang, Yihua Cai, Shuhua Li, Songtao Shi, Xueli Mao*, Zetao Chen*,The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering, Bioactive Materials, 2025, 49:418-436.

2.Xuan Zhou#, Junlong Xue#, Yanshu Zhang#, Ruidi Xia, Zhengjie Shan, Linjun Zhang, Mixiao Gui, Guanqi Liu*, Zetao Chen*. Evolution of Biological Hydroxyapatite Modification Strategy: Anti-Inflammation Approach Rescues the Calcium–NOD-Like Receptor–Inflammation Axis-Mediated Periodontal Redevelopment Failure. Biomater Res. 2025;29:0131.

3.Guanqi Liu#, Ruidi Xia#, Mixiao Gui#, Linjun Zhang, Xuan Zhou, Junlong Xue,Yihua Cai, Yang Cao*, Yin Xiao*, Zetao Chen*.Turn Hood into Good: Recycling Silicon from Mesoporous Silica Nanoparticles through Magnesium Modification to Lower Toxicity and Promote Tissue Regeneration. ACS Nano 2024 18 (47), 32932-32949

4.Guanqi Liu, Jiahui Lin, Xiaoyan Chen, Runheng Liu*, Gingival Fibroblast Suppress the Osteogenesis Process Mediated by Bone Substitute Materials via WNT/β-catenin Signaling Pathway in vitro and in vivo. Frontiers in Bioengineering and Biotechnology, 2025, 13:1521134.

5.Guanqi Liu#, Shudan Deng#, Runzhong Liu, Yuanxiang Liu, Quan Liu, Shiyu Wu, Zhuofan Chen*, Runheng Liu*, Precise multi-factor immediate implant placement decision models based on machine learning. Scientific Reports. 2025, 15:5143.

6.Guanqi Liu#, Shudan Deng#, Jiahui Lin, Xiaoyan Chen, Runheng Liu*, Biomechanical analysis of maxillary posterior three unit bridge supported misial straight implant and distal tilted implant. Frontiers in Bioengineering and Biotechnology. 2025, 13:1546656.

7.Guanqi Liu#, Linjun Zhang#, Xuan Zhou#, Junlong Xue, Ruidi Xia, Xuejing Gan, Chunxiao Lv, Yanshu Zhang, Xueli Mao, Xiaoxing Kou, Songtao Shi*, Zetao Chen*, Inducing the “re-development state” of periodontal ligament cells via tuning macrophage mediated immune microenvironment, Journal of Advanced Research, 2023, 18: S2090-1232(23)00225-4

8.Guanqi Liu#, Xuan Zhou#, Linjun Zhang#, Yang Zou, Junlong Xue, Ruidi Xia, Nuerbiya Abuduxiku, Xuejing Gan, Runheng Liu, Zhuofan Chen*, Yang Cao*, Zetao Chen*, Cell-free immunomodulatory biomaterials mediated in situ periodontal multi-tissue regeneration and their immunopathophysiological processes, Materials Today Bio, 2022, 16: 100432

9.Guanqi Liu#, Xiaoshuang Wang, Xuan Zhou, Linjun Zhang, Jiaomei Mi, Zhengjie Shan, Baoxin Huang, Zhuofan Chen*, Zetao Chen*, Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications, Theranostics, 2020, 10(3): 1074-1089

12.Lingling Chen; Guanqi Liu(共一); Jinyan Wu; Xuan Zhou; Yiming Zhao; Zetao Chen; Zhengmei Lin; Yin Xiao ; Multi-faceted effects of mesenchymal stem cells (MSCs) determined by immune microenvironment and their implications on MSC/biomaterial-based inflammatory disease therapy, Applied Materials Today, 2020, 18: 100485

13. Runheng Liu#, Shoucheng Chen#, Peina Huang, Guanqi Liu, Pu Luo, Zhipeng Li, Yin Xiao, Zhuofan Chen*, Zetao Chen*. Immunomodulation-based strategy for improving soft tissue and metal implant integration and its implications in the development of metal soft tissue materials. Advanced Functional Materials, 2020, 30, 21, 1910672.

10.Guanqi Liu, Runheng Liu*. Maxillary Immediate Molar Implant Placement into Palatal Root Socket: A Case Report of 2 Year Follow Up. Cureus Journal of Medical Science, 2024,9;16(10):e71152.

 【参编教材与论著】

1. 2020年 参编《口腔基础研究导论》 人民卫生出版社 978-7-117-29325-9

2. 2024年 参编《单颗后牙种植修复决策路径及操作实践》 人民卫生出版社 978-7-1173-6825-4

【获奖及学术荣誉】

1. 2024年 2023年广东省本科高校“新医科”视域下课程思政案例三等奖

2. 2024年 2024年光华园丁奖一等奖

3. 2023年 中山大学第十一届本科教育教学成果奖一等奖

【社会兼职】

广东省精准医学应用学会口腔修复种植分会委员

【联系方式】

地址：广州市越秀区陵园西路56号

电话：020-83866394

邮箱：liugq5@mail.sysu.edu.cn