刘冠琪 | 中山大学附属口腔医院

刘冠琪

副主任医师硕士生导师

导师简介

【学位 / 学历】

博士研究生

【学术简历】

2009.09-2014.06 中大大学口腔医学学士

2014.08-2017.06 中山大学口腔临床医学硕士

2017.09-2020.06 中山大学口腔基础医学博士

【研究方向】

1.牙周组织的重建与再生

2.口腔生物材料

3.口腔正畸学

【主持课题】

1.2025-01-01至2027-12-31，FA-Mg-MSNs靶向调控巨噬细胞线粒体-内质网触点重塑衰老微环境促进牙周再生的研究，广东省自然科学基金-面上项目，10万元

2.2023-01-01 至 2025-12-31，叶酸修饰的Mg-MSNs靶向调控巨噬细胞线粒体功能稳态促进牙周复合体再生的研究，国自然青年项目，30万元

3.2020-10 至 2023-09 ，基于免疫微环境调控牙周多组织再生的镁基纳米支架的研发及机制研究，广东省基础与应用基础研究：区域联合基金-青年基金项目，10万元

4.2020-10 至 2022-06，基于免疫微环境调控促进牙槽骨-牙周纤维-牙骨质复合体再生的研究，中国博士后科学基金面上项目，12万元

【发表论文】

1. Guanqi Liu#, Junlong Xue#, Xuan Zhou#, Mixiao Gui, Ruidi Xia, Yanshu Zhang, Yihua Cai, Shuhua Li, Songtao Shi, Xueli Mao*, Zetao Chen*,The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering, Bioactive Materials, 2025, 49:418-436.

2. Guanqi Liu#, Xiaoyan Chen, Jiahui Lin, Yuhan Hou, Runheng Liu*. Host-Targeted Immunomodulation via BAPTA@MSNs Nanoplatform Enhances Collagen Membrane Barrier Function by Regulating Macrophage Fusion and Phosphatidylserine Externalization. Materials & Design, 2026, 263: 115644.

3.Xuan Zhou#, Junlong Xue#, Yanshu Zhang#, Ruidi Xia, Zhengjie Shan, Linjun Zhang, Mixiao Gui, Guanqi Liu*, Zetao Chen*. Evolution of Biological Hydroxyapatite Modification Strategy: Anti-Inflammation Approach Rescues the Calcium–NOD-Like Receptor–Inflammation Axis-Mediated Periodontal Redevelopment Failure. Biomater Res. 2025;29:0131.

4.Guanqi Liu#, Ruidi Xia#, Mixiao Gui#, Linjun Zhang, Xuan Zhou, Junlong Xue,Yihua Cai, Yang Cao*, Yin Xiao*, Zetao Chen*.Turn Hood into Good: Recycling Silicon from Mesoporous Silica Nanoparticles through Magnesium Modification to Lower Toxicity and Promote Tissue Regeneration. ACS Nano 2024 18 (47), 32932-32949

5.Guanqi Liu, Jiahui Lin, Xiaoyan Chen, Runheng Liu*, Gingival Fibroblast Suppress the Osteogenesis Process Mediated by Bone Substitute Materials via WNT/β-catenin Signaling Pathway in vitro and in vivo. Frontiers in Bioengineering and Biotechnology, 2025, 13:1521134.

6.Guanqi Liu#, Shudan Deng#, Runzhong Liu, Yuanxiang Liu, Quan Liu, Shiyu Wu, Zhuofan Chen*, Runheng Liu*, Precise multi-factor immediate implant placement decision models based on machine learning. Scientific Reports. 2025, 15:5143.

7.Guanqi Liu#, Shudan Deng#, Jiahui Lin, Xiaoyan Chen, Runheng Liu*, Biomechanical analysis of maxillary posterior three unit bridge supported misial straight implant and distal tilted implant. Frontiers in Bioengineering and Biotechnology. 2025, 13:1546656.

8.Guanqi Liu#, Linjun Zhang#, Xuan Zhou#, Junlong Xue, Ruidi Xia, Xuejing Gan, Chunxiao Lv, Yanshu Zhang, Xueli Mao, Xiaoxing Kou, Songtao Shi*, Zetao Chen*, Inducing the “re-development state” of periodontal ligament cells via tuning macrophage mediated immune microenvironment, Journal of Advanced Research, 2023, 18: S2090-1232(23)00225-4

9.Guanqi Liu#, Xuan Zhou#, Linjun Zhang#, Yang Zou, Junlong Xue, Ruidi Xia, Nuerbiya Abuduxiku, Xuejing Gan, Runheng Liu, Zhuofan Chen*, Yang Cao*, Zetao Chen*, Cell-free immunomodulatory biomaterials mediated in situ periodontal multi-tissue regeneration and their immunopathophysiological processes, Materials Today Bio, 2022, 16: 100432

10.Guanqi Liu#, Xiaoshuang Wang, Xuan Zhou, Linjun Zhang, Jiaomei Mi, Zhengjie Shan, Baoxin Huang, Zhuofan Chen*, Zetao Chen*, Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications, Theranostics, 2020, 10(3): 1074-1089

11.Lingling Chen; Guanqi Liu(共一); Jinyan Wu; Xuan Zhou; Yiming Zhao; Zetao Chen; Zhengmei Lin; Yin Xiao ; Multi-faceted effects of mesenchymal stem cells (MSCs) determined by immune microenvironment and their implications on MSC/biomaterial-based inflammatory disease therapy, Applied Materials Today, 2020, 18: 100485

12. Runheng Liu#, Shoucheng Chen#, Peina Huang, Guanqi Liu, Pu Luo, Zhipeng Li, Yin Xiao, Zhuofan Chen*, Zetao Chen*. Immunomodulation-based strategy for improving soft tissue and metal implant integration and its implications in the development of metal soft tissue materials. Advanced Functional Materials, 2020, 30, 21, 1910672.

13.Guanqi Liu, Runheng Liu*. Maxillary Immediate Molar Implant Placement into Palatal Root Socket: A Case Report of 2 Year Follow Up. Cureus Journal of Medical Science, 2024,9;16(10):e71152.

14.Runheng Liu^#, Jiahui Lin, Xiaoyan Chen, Yuhan Hou, Guanqi Liu*, Yan Wang*. From challenge to competence: the role of learning engagement in mediating stress and performance among clinical medical students in English-medium dental education. Frontiers in Medicine. 2025,12:1675855.

15.刘润恒#, 刘冠琪*. 无托槽隐形矫治治疗闭锁性深覆𬌗拔牙病例1例. 中国临床案例成果数据库. 2025,07(01):E2025-E2025.