【学位 / 学历】

博士 / 博士研究生

【学术简历】

1989.09-1996.07  华西医科大学口腔医学院口腔医学七年制专业获硕士学位

1997.09-2000.07  华西医科大学口腔医学院口腔内科学专业获博士学位

【研究方向】

1.口腔细菌之间以及细菌与宿主之间相互作用的研究

2.口腔微生物群落结构及功能的研究

3.口腔致病菌在远隔器官疾病中的致病机制研究

【主持课题】

2017年1月-2020年12月：《具核梭杆菌与口腔链球菌之间相互作用的分子机制研究》，国家自然科学基金面上项目（批准号：81670982）58万（直接费用）

【发表论文】

1. Zhou J, Yuan Z, Yang R, Liu T, Lu X, Huang W, Guo L，Coaggregated E. faecalis with F. nucleatum regulated environmental stress responses and inflammatory effects，Appl Microbiol Biotechnol，2024;108(1):336

2. Yang R., Liu T., Pang C., Cai Y., Lin Z., Guo L*, Wei X，The Regulatory Effect of Coaggregation between Fusobacterium nucleatum and Streptococcus gordonii on the Synergistic Virulence to Human Gingival Epithelial Cells，Frontiers in Cellular and Infection Microbiology，2022;12:879423

3. Lu XJ, Liu TJ, Zhou JN, Liu J, Yuan ZJ, Guo L，Subgingival microbiome in periodontitis and type 2 diabetes mellitus: an exploratory study using metagenomic sequencing，Journal of Periodontal & Implant Science，2022;52(4):282-297

4. Liu T.J., Yang R.Q., Zhou J.N., Lu X.J., Yuan Z.J., Wei X, Guo L， Interactions between Streptococcus gordonii and Fusobacterium nucleatum altered bacterial transcriptional profiling and attenuated the immune responses of macrophages，Frontiers in Cellular and Infection Microbiology，2022;11:783323

5. Zou JN, Liu TJ, Guo L，Effectiveness of XP-Endo Finisher and passive ultrasonic irrigation on intracanal medicament removal from root canals:a systematic review and meta-analysis，BMC Oral Health，2021; 21(1):294

6. Liu TJ, Zou JN, Guo L，Impact of different regenerative techniques and materials on the healing outcome of endodontic surgery: a systematic review and meta-analysis. International Endodontic Journal，2021;54(4):536-555

7. Fan C, Guo L, Gu H, Huo Y, Lin H. Alterations in oral-nasal-pharyngeal microbiota and salivary proteins in mouth breathing children，Frontiers in Microbiology，2020;11:575550

8. Cao Y, Zhou Y, Chen D, Wu R, Guo L*,Lin H，Proteomic and metabolic characterization of membrane vesicles derived from Streptococcus mutans at different pH values. Appl Microbiol Biotechnol， 2020;104(22):9733-9748

9. Liu TJ, Liu J, Liu JW, Yang RQ, Lu XJ, He X, Shi W, Guo L，Interspecies interactions between Streptococcus mutans and Streptococcus agalactiae in vitro. Front Cell Infect Microbiol，2020；10:344

【联系方式】

地址：广州市越秀区陵园西路56号中山大学附属口腔医院牙体牙髓病科

邮箱：guolh5@sysu.edu.cn