【学位 / 学历】

博士 / 博士研究生

【学术简历】

1878-1983 佳木斯大学口腔医学专业获学士学位

1985-1988 白求恩医科大学口腔修复学专业硕士学位

1996-2000 日本德岛大学齿学部口腔正畸学专业获博士学位

2000-2005 美国宾夕法尼亚大学肿瘤病毒学博士后

【研究方向】

口腔干细胞与细胞外囊泡在骨组织再生及口腔疾病治疗中的基础研究与临床转化

【主持课题】

1. 2021.01.01-2024.12.31：《牙周膜干细胞外泌体miR-92a-3p通过Mfn1/ROS/HIF1α/LDHA通路调节巨噬细胞代谢和破骨分化》，国家自然科学基金、面上项目，55万

2. 2023.01.01-2026.12.31：《牙周膜干细胞线粒体移植通过TOB2/SMAD5/PKM2赋能通路调控牙周骨稳态的机制研究》，国家自然科学基金、面上项目，52万

【发表论文】

1.Yingying Peng, Tingting Zhao, Shuxuan Rong, Shuqing Yang ,Wei Teng*,Yunyi Xie* and Yan Wang*.Y. Young small extracellular vesicles rejuvenate replicative senescence by remodeling Drp1 translocation-mediated mitochondrial dynamics. Journal of  Nanobiotechnology. 2024 ;22(1):543

2.Niu Q#, Lin C#, Yang S, Rong S, Wei J, Zhao T, Peng Y, Cheng Z, Xie Y*, Wang Y*. FoxO1-Overexpressed Small Extracellular Vesicles Derived from hPDLSCs Promote Periodontal Tissue Regeneration by Reducing Mitochondrial Dysfunction to Regulate Osteogenesis and Inflammation. Int J Nanomedicine. 2024 ;19:8751-8768

3.Deqian Tang1# , Manqing Liu1# , Shenghan Gao , Haipeng Sun , Yingying Peng , Yi Li 1 , Yan Wang, Xiaoxiao Wang,*, Huan Chen*.Thermally engineered MSC-derived exosomes ameliorate colitis in mice by restoring the imbalanced Th17/Treg cell ratio. International Immunopharmacology. 2023 ;125:111077

4.Qingru Niu#，Huan Chen#, Qianmin Ou, Shuqing Yang, Yingying Peng, Yunyi Xie, Le Yu, Zhilan Cheng, Yang Cao*, Yan Wang*. Klotho enhances bone regenerative function of hPDLSCs via modulating immunoregulatory function and cell autophagy. J Orthop Surg Res. 2023;18(1):400

5.Lu ZZ, Sun C, Zhang X, Peng Y, Wang Y, Zeng Y, Zhu N, Yuan Y, Zeng MS. Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis.Sci Adv2023;9(21):eadg1778.

6.Nannan Zhu, Qian Wang, Zhidong Wu, Yan Wang, Mu-Sheng Zeng, and Yan Yuan .EBV LMP1-activated mTORC1 and mTORC2 Coordinately Promote Nasopharyngeal Cancer Stem Cell Properties. J Virol. 2022;96(5):e0194121.

Yunyi Xie1#, Le Yu1#, Zhilan Cheng1#, Yingying Peng1, Zeyuan Cao1, Beichen Chen1, Yihong Duan1, Yan Wang*. SHED-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy. Journal of Nanobiotechnology. 2022 May 21;20(1):239.

7.Weikang,Yao Ding, Zhengzhou Lu, Yan Wang, Yan Yun. Kaposi’s sarcoma-associated herpesvirus vFLIP promotes MEndT to generate hybrid M/E state for tumorigenesis.PLoS Pathog. 2021;17(12): e1009600.

8.Nannan Zhu, Xiaoting Xu, Yan Wang, Mu-Sheng Zeng, Yan Yun. EBV latent membrane proteins promote hybrid epithelial-mesenchymal and extreme mesenchymal states of nasopharyngeal carcinoma cells for tumorigenicity. PLOS Pathogens.2021Aug 18;17(8):e1009873.

Yao Ding, Weikang Chen, Zhengzhou Lu, Yan Wang, Yan Yuan. Kaposi's Sarcoma-associated Herpesvirus Promotes Mesenchymal-to-Endothelial Transition by Resolving the Bivalent Chromatin of PROX1 Gene. PLOS Pathogens, PLoS Pathog. 2021;17(9):e1009847.

9.Qianmin Ou#, Shaohan Zhang#, Chuanqiang Fu, Le Yu, Peikun Xin, Zhipeng Gu,Zeyuan Cao, Jun Wu*, Yan Wang*. More natural more better: triple natural anti.oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing. Journal of Nanobiotechnology. 2021 ;19(1):237.

10.Jiayuan Hu, Yan Wang, Yan Yuan. Inhibitors of APE1 redox function effectively inhibit γ-herpesvirusreplication in vitro and in vivo. Antiviral Research. 2021;185:104985.

11.Lingping Tan#, Zeyuan Cao#, Huan Chen, Yunyi Xie, Le Yu, Chuanqiang Fu, Wei Zhao* and Yan Wang*. Curcumin reduces apoptosis and promotes osteogenesis of human periodontal ligament stem cells under oxidative stress in vitro and in vivo. Life Sciences, 2021;270:  119125.

12.Zeyuan Cao#, Yunyi Xie#, Le Yu, Yi Li, and Yan Wang*. Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. Stem Cell Research & Therapy 2020 Jul 31;11(1):329.

13.Qianmin Ou, Keqing Huang , Chuanqiang Fu, Chunlin Huang , Yifei Fang, Zhipeng Gu *, Jun Wu, Yan Wang*. Nanosilver-incorporated halloysite nanotubes/gelatin methacrylate hybrid hydrogel with osteoimmunomodulatory and antibacterial activity for bone regeneration. Chemical Engineering Journal, 2020;382:123019.

14.Xiayi Wu#, Zeyuan Cao#, Huan Chen, Qianmin Ou, Xiaojun Huang, Yan Wang*. Downregulation of Linc-RNA Activator of Myogenesis lncRNA participates in FGF2 mediated-proliferation of human periodontal ligament stem cells. Running title: Linc-RAM participates in PDLSCs . Journal of Periodontology, 2020;91(3):422–427.

15.Qian Wang#, Nannan Zhu#, Jiayuan Hu, Yan Wang, Jun Xu, Qiong Gu, Paul M Lieberman,Yan Yuan. The mTOR Inhibitor Manassantin B Reveals a Crucial Role of mTORC2 Signaling in Epstein-Barr Virus Reactivation. J Biol Chem. 2020,22;295(21):7431-7441.

【社会兼职】

《中华口腔医学（电子版）》杂志特邀编委

【联系方式】

地址：广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院（510055）

电话：020-87330592

邮箱：wang93@mail.sysu.edu.cn