【学位 / 学历】
博士 / 研究生
【学术简历】
1999.09-2003.07 中国农业大学生物学院生物科学专业获学士学位
2003.09-2008.06 中国农业大学生物学院生理学专业 获博士学位
【研究方向】
1. 口腔颅颌面罕见遗传病及头颈肿瘤相关疾病的发生机制与防治干预研究
2. 环境不良因素诱导颅颌面组织损伤的发生机制及缺损修复再生研究
【主持课题】
1. 2018.01-2021.12：《mTORC1和eIF2α信号通路参与cohesin基因突变导致的颅颌面部成骨缺陷的发生》，国家自然科学基金面上项目，54万元
2. 2020.01-2023.12：《核糖体DNA拷贝丢失提高RNA聚合酶I与mTOR靶向药联合治疗头颈鳞癌疗效的机制研究》，国家自然科学基金面上项目，55万元
3. 2021.01-2023.12：《染色体粘合素基因突变通过内质网应激介导的PERK-eIF2α-ATF4通路导致颅颌面与四肢骨发育缺陷的生物学机制研究？，广东省自然科学基金委-面上项目，10万元
4. 2023.01-2025.12：《NLRP3炎症小体激活和自噬功能障碍参与重金属镉诱导骨质疏松的作用及机制研究》，广东省基础与应用基础研究基金项，10万元
5. 2023.11-2026.10：《头颈鳞癌核糖体DNA拷贝数丢失对mTOR信号通路抑制剂与RNA聚合酶I抑制剂联合抗癌的促进作用及机制研究》，广东省基础与应用基础研究基金项目区域联合基金-地区培育项目。30万元
6. 2020.01-2021.12：《 染色体粘合素基因突变通过核仁应激损伤导致颅颌面与四肢骨发育缺陷的研究》，中央高校基本科研业务费中山大学青年教师重点培育项目，30万元
7. 2020.01-2022.12：《核仁应激在Cohesin突变导致颅颌面与四肢骨发育畸形中的作用及其机制研究》，广东省“登峰计划”一流医院建设科研培育项目，30万元
8. 2020.01-2020.12：《染色体粘合素基因突变通过核仁应激损伤导致颅颌面与四肢骨发育缺陷的研究》，四川大学华西口腔疾病研究国家重点实验室2020年开放课题，15万元
【发表论文】
1. Pengchao Zheng, Shanwei Shi, Zheng Wang, Yuna Ji，Huigen Luo, Huiya Ouyang, Yuhan Shi, Yihan Xing, Dingji Li, Jianbo Sun, Chengnong Guan, Baoshan Xu*. Dihydroartemisinin Inhibits Oral Cancer Cell Migration, associated with Impairment of Cytoskeleton Organization and Cell Membrane Fluidity. Food Bioscience, Volume 68, June 2025, 106648.
2. Renjie Hu#, Huigen Luo#, Yuna Ji#, Zheng Wang, Pengchao Zheng, Huiya Ouyang, Xinchen Wang, Yun Wang, Baicheng Bao, Guiqing Liao, Baoshan Xu*. Activation of NLRP3 signaling contributes to cadmium-induced bone defects, associated with autophagic flux obstruction. Science of the Total Environment. 2023 June 13; 893:164787.
3. Yuna Ji, Pengchao Zheng, Xinchen Wang, Renjie Hu, Huigen Luo, Baoshan Xu*. Oral administration of alpha-ketoglutarate partially ameliorates Cadmium-compromised BMSC mobilization and cranial bone repair. Food Bioscience. Volume 66, April 2025, 106169.
4. Xinchen Wang#, Yue Zhou#, Chuyi Luo#, Jianxin Zhao, Yuna Ji, Zheng Wang, Pengchao Zheng, Dingji Li, Yuhan Shi, Aki Nishiura, Naoyuki Matsumoto, Yoshitomo Honda, Baoshan Xu*, Fang Huang*. Senolytics ameliorate the failure of bone regeneration through the cell senescence-related inflammatory signalling pathway. Biomedicine & Pharmacotherapy, Volume 175, June 2024, 116606
5. Zheng Wang#, Yuhan Shi#, Pengchao Zheng, Xinchen Wang, Yihan Xing, Dingji Li, Hua Tu, Baoshan Xu*. Improving diabetic wound healing: The therapeutic potential of allulose supplement in diabetic skin tissue repair and inflammation modulation. Food Bioscience, Volume 62, December 2024, 105439.
6. Shanwei Shi#, Huigen Luo#, Yuna Ji#, Huiya Ouyang#, Zheng Wang, Xinchen Wang, Renjie Hu, Lihong Wang, Yun Wang, Juan Xia, Bin Cheng, Baicheng Bao, Xin Li, Guiqing Liao, Baoshan Xu*. Repurposing Dihydroartemisinin to Combat Oral Squamous Cell Carcinoma, Associated with Mitochondrial Dysfunction and Oxidative Stress. Oxid Med Cell Longev. 2023 Feb 16:2023:9595201.
7. Huigen Luo, Renjie Gu, Huiya Ouyang, Lihong Wang, Shanwei Shi, Yuna Ji, Baicheng Bao, Guiqing Liao, Baoshan Xu*. Cadmium exposure induce osteoporosis and adipogenesis through cellular senescence, associated with activation of NF-κB pathway and mitochondrial dysfunction. Environment Pollution. 2021 Aug 24; 290:118043.
8. Weihuai Gu#, Lihong Wang#, Renjie Gu, Huiya Ouyang, Baicheng Bao, Liwei Zheng, Baoshan Xu*. Defects of cohesin loader lead to bone dysplasia associated with transcriptional disturbance. Journal of Cellular Physiology. 2021 Jun 25.
9. Shanwei Shi, Huigen Luo, Lihong Wang, Hua Li, Yujie Liang, Juan Xia, Zhi Wang, Bin Cheng, Linfeng Huang, Guiqing Liao*, Baoshan Xu*. Combined inhibition of RNA polymerase I and mTORC1/2 synergize to combat oral squamous cell carcinoma. Biomedicine & Pharmacotherapy, 2021 Jan; 133:110906.
10. Leonardo Gomes de Lima, Edmund Howe, Vijay Pratap Singh, Tamara Potapova, Hua Li, Baoshan Xu, Jemma Castle, Steve Crozier, Christine J Harrison, Steve C Clifford, Karen H Miga, Sarra L Ryan, Jennifer L Gerton*. PCR amplicons identify widespread copy number variation in human centromeric arrays and instability in cancer. Cell Genomics. 2021 Dec;1(3):100064.
):e2307601. (IF: 27.4)
【社会兼职】
1. 中华口腔医学会口腔遗传病与罕见病专业委员会常务委员
2. 中华口腔医学会口腔生物医学专业委员会会员
3. 中华口腔医学会会员
4. International Association for Dental Research Member
【联系方式】
地址：广州市越秀区中山二路74号，中山大学（北校区），光华口腔医学院，口腔医学研究所（邮政编码：510080）
电话：020-87330589
邮箱：xubsh3@mail.sysu.edu.cn
