寇晓星 | 中山大学附属口腔医院

研究员博士生导师硕士生导师

【学位 / 学历】

2000-2005 西安交通大学口腔医学专业获学士学位

2006-2011 北京大学口腔颌面外科学（硕博连读）专业获博士学位

2011-2014 北京大学口腔医学院口腔正畸科博士后

1. 2024年：《干细胞及囊泡与炎症微环境调控和组织再生修复》，广州市科技菁英“领航”项目，30万

2. 2022 年：《杰青培育项目》，院内资助人才培养计划，50万

3. 2021 年：《Caveolin-1介导的囊泡释放与內吞在牙龈间充质干细胞功能调控和组织再生中的作用及机制研究》，国自然面上项目，55万

4. 2021 年：《国家高层次人才青年项目》，国家级人才项目，140万

5. 2020 年：《颅颌干细胞免疫调节及组织再生在牙周病治疗中的新策略-第一子项目》，“珠江人才计划”引进创新创业团队，400万

1. 2024年全球前2%顶尖科学家榜单- Elsevier

2. 2023年 2022年度广东省精准医学科学技术奖科技创新奖-科技进步二等奖

3. 2020年 “珠江人才计划”青年拔尖人才项目-广东省科技厅

4. 2019年广东省医学青年杰出人才-广东省卫健委

1. 中华口腔医学会口腔生物医学专委会委员

2. 中国生物医学工程学会组织工程与再生医学分会委员

3. 广东省生物医学工程学会生物3D打印与再生医学分会常委

4. International Journal of Oral Scienc 编委

5. 中华口腔医学研究杂志（电子版）编委

地址：中山大学北校园光华口腔医学院；中山大学附属口腔医院正畸科

【研究方向】

1. 骨代谢调控及生物力作用机理

2. 骨及软骨损伤修复与再生

3. 干细胞及胞外囊泡与组织再生和疾病治疗

【主持课题】

【发表论文】

1. Shao, Y.; Du, Y.; Chen, Z.; Xiang, L.; Tu, S.; Feng, Y.; Hou, Y.; Kou, X.*; Ai, H.*, Mesenchymal stem cell-mediated adipogenic transformation: a key driver of oral squamous cell carcinoma progression. Stem cell research & therapy 2025, 16 (1), 12.

2. Yang, Y.; Wang, J.; Lin, X.; Zhang, Z.; Zhang, M.; Tang, C.; Kou, X.*; Deng, F.*, TNF-alpha-licensed exosome-integrated titaniumaccelerated T2D osseointegration by promoting autophagy-regulated M2 macrophage polarization. Biochem Biophys Res Commun 2024, 727, 150316.

3. Xiang, L.; An, Z.; Wu, X.; Wang, J.; Cai, S.; Lu, Y.; Li, L.; Huang, W.; Wu, D.; Lu, L.; Shi, S.; Bi, H.*; Kou, X.*, Carbon Dot-Loaded Apoptotic Vesicles Improve the Liver Kupffer Cell-Mediated Antibacterial Effect to Synergistically Alleviate Sepsis. ACS Nano 2024, 18 (26), 16726-16742.

4. Li, Y.; Li, Y.; Liu, C.; Yu, X.; Gan, Z.; Xiang, L.; Zheng, J.; Meng, B.; Yu, R.; Chen, X.; Kou, X.*; Cao, Y.*; Ai, T.*, Mechanical force-activated CD109 on periodontal ligament stem cells governs osteogenesis and osteoclast to promote alveolar bone remodeling. Stem Cells Transl Med 2024.

5. Huang, W.; Wang, B.; Ou, Q.; Zhang, X.; He, Y.; Mao, X.; Wei, X.*; Kou, X.*, ASC-expressing pyroptotic extracellular vesicles alleviate sepsis by protecting B cells. Mol Ther 2024, 32 (2), 395-410.

6. Yang, B.; Li, X.; Fu, C.; Cai, W.; Meng, B.; Qu, Y.; Kou, X. *; Zhang, Q.*, Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint. Front Endocrinol (Lausanne) 2023, 14, 1158744.

7. Meng, B.; Yang, B.; Qu, Y.; Liu, Y.; Wu, D.; Fu, C.; He, Y.; Chen, X.; Liu, C.; Kou, X.*; Cao, Y.*, Dual Role of Interleukin-20 in Different Stages of Osteoclast Differentiation and Its Osteoimmune Regulation during Alveolar Bone Remodeling. Int J Mol Sci 2023, 24 (4).

8. Ma, L.; Chen, C.; Liu, D.; Huang, Z.; Li, J.; Liu, H.; Kin Kwok, R. T.; Tang, B.; Sui, B.; Zhang, X.; Tang, J.; Mao, X.; Huang, W.; Shi, S.*; Kou, X.*, Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair. Bioact Mater 2023, 19, 626-641.

9. Lei, F.; Huang, Z.; Ou, Q.; Li, J.; Liu, M.; Ma, L.; Tan, L.; Lin, Z.*; Kou, X.*, Apoptotic vesicles rejuvenate mesenchymal stem cells via Rab7-mediated autolysosome formation and alleviate bone loss in aging mice. Nano Research 2023.

10. Chen, L.; Ou, Q.; Kou, X., Extracellular vesicles and their indispensable roles in pathogenesis and treatment of inflammatory bowel disease: A comprehensive review. Life sciences 2023, 327, 121830.

11. Cao, Z.; Li, P.; Li, Y.; Zhang, M.; Hao, M.; Li, W.; Mao, X.; Mo, L.; Yang, C.; Ding, X.; Yang, Y. Y.; Yuan, P.*; Shi, S.*; Kou, X.*, Encapsulation of Nano-Bortezomib in Apoptotic Stem Cell-Derived Vesicles for the Treatment of Multiple Myeloma. Small 2023, e2301748.

12. Wu, D.; Zhao, L.; Sui, B.; Tan, L.; Lu, L.; Mao, X.; Liao, G.; Shi, S.; Cao, Y.*; Yang, X.*; Kou, X.*, An Appearance Data-Driven Model Visualizes Cell State and Predicts Mesenchymal Stem Cell Regenerative Capacity. Small Methods 2022, e2200087.

13. Ou, Q.; Tan, L.; Shao, Y.; Lei, F.; Huang, W.; Yang, N.; Qu, Y.; Cao, Z.; Niu, L.; Liu, Y.; Kou, X.*; Shi, S.*, Electrostatic Charge-Mediated Apoptotic Vesicle Biodistribution Attenuates Sepsis by Switching Neutrophil NETosis to Apoptosis. Small 2022, e2200306.

14. Kou, X.*; Liu, J.; Wang, D.; Yu, M.; Li, C.; Lu, L.; Chen, C.; Liu, D.; Yu, W.; Yu, T.; Liu, Y.; Mao, X.; Naji, A.; Cai, T.; Sun, L.*; Shi, S.*, Exocrine pancreas regeneration modifies original pancreas to alleviate diabetes in mouse models. Sci Transl Med 2022, 14 (656), eabg9170.

15. He, Y.; Qu, Y.; Meng, B.; Huang, W.; Tang, J.; Wang, R.; Chen, Z.; Kou, X.*; Shi, S.*, Mesenchymal stem cells empower T cells in the lymph nodes via MCP-1/PD-L1 axis. Cell Death Dis 2022, 13 (4), 365.

16. Wang, P.; Zhao, Y.; Wang, J.; Wu, Z.; Sui, B.; Mao, X.; Shi, S.; Kou, X., Dephosphorylation of Caveolin-1 Controls C-X-C Motif Chemokine Ligand 10 Secretion in Mesenchymal Stem Cells to Regulate the Process of Wound Healing. Front Cell Dev Biol 2021, 9, 725630.

17. Wang, J.; Cao, Z.; Wang, P.; Zhang, X.; Tang, J.; He, Y.; Huang, Z.; Mao, X.; Shi, S.; Kou, X., Apoptotic Extracellular Vesicles Ameliorate Multiple Myeloma by Restoring Fas-Mediated Apoptosis. ACS Nano 2021, 15 (9), 14360-14372.

18. He, D.; Liu, F.; Cui, S.; Jiang, N.; Yu, H.; Zhou, Y.*; Liu, Y.*; Kou, X.*, Mechanical load-induced H2S production by periodontal ligament stem cells activates M1 macrophages to promote bone remodeling and tooth movement via STAT1. Stem cell research & therapy 2020, 11 (1), 112.

【获奖及学术荣誉】

【社会兼职】

【联系方式】

1. Shao, Y.; Du, Y.; Chen, Z.; Xiang, L.; Tu, S.; Feng, Y.; Hou, Y.; Kou, X.; Ai, H., Mesenchymal stem cell-mediated adipogenic transformation: a key driver of oral squamous cell carcinoma progression. Stem cell research & therapy 2025, 16 (1), 12.

2. Yang, Y.; Wang, J.; Lin, X.; Zhang, Z.; Zhang, M.; Tang, C.; Kou, X.; Deng, F., TNF-alpha-licensed exosome-integrated titaniumaccelerated T2D osseointegration by promoting autophagy-regulated M2 macrophage polarization. Biochem Biophys Res Commun 2024, 727, 150316.

3. Xiang, L.; An, Z.; Wu, X.; Wang, J.; Cai, S.; Lu, Y.; Li, L.; Huang, W.; Wu, D.; Lu, L.; Shi, S.; Bi, H.; Kou, X., Carbon Dot-Loaded Apoptotic Vesicles Improve the Liver Kupffer Cell-Mediated Antibacterial Effect to Synergistically Alleviate Sepsis. ACS Nano 2024, 18 (26), 16726-16742.

4. Li, Y.; Li, Y.; Liu, C.; Yu, X.; Gan, Z.; Xiang, L.; Zheng, J.; Meng, B.; Yu, R.; Chen, X.; Kou, X.; Cao, Y.; Ai, T.*, Mechanical force-activated CD109 on periodontal ligament stem cells governs osteogenesis and osteoclast to promote alveolar bone remodeling. Stem Cells Transl Med 2024.

5. Huang, W.; Wang, B.; Ou, Q.; Zhang, X.; He, Y.; Mao, X.; Wei, X.; Kou, X., ASC-expressing pyroptotic extracellular vesicles alleviate sepsis by protecting B cells. Mol Ther 2024, 32 (2), 395-410.

6. Yang, B.; Li, X.; Fu, C.; Cai, W.; Meng, B.; Qu, Y.; Kou, X. ; Zhang, Q., Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint. Front Endocrinol (Lausanne) 2023, 14, 1158744.

7. Meng, B.; Yang, B.; Qu, Y.; Liu, Y.; Wu, D.; Fu, C.; He, Y.; Chen, X.; Liu, C.; Kou, X.; Cao, Y., Dual Role of Interleukin-20 in Different Stages of Osteoclast Differentiation and Its Osteoimmune Regulation during Alveolar Bone Remodeling. Int J Mol Sci 2023, 24 (4).

8. Ma, L.; Chen, C.; Liu, D.; Huang, Z.; Li, J.; Liu, H.; Kin Kwok, R. T.; Tang, B.; Sui, B.; Zhang, X.; Tang, J.; Mao, X.; Huang, W.; Shi, S.; Kou, X., Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair. Bioact Mater 2023, 19, 626-641.

9. Lei, F.; Huang, Z.; Ou, Q.; Li, J.; Liu, M.; Ma, L.; Tan, L.; Lin, Z.; Kou, X., Apoptotic vesicles rejuvenate mesenchymal stem cells via Rab7-mediated autolysosome formation and alleviate bone loss in aging mice. Nano Research 2023.

11. Cao, Z.; Li, P.; Li, Y.; Zhang, M.; Hao, M.; Li, W.; Mao, X.; Mo, L.; Yang, C.; Ding, X.; Yang, Y. Y.; Yuan, P.; Shi, S.; Kou, X.*, Encapsulation of Nano-Bortezomib in Apoptotic Stem Cell-Derived Vesicles for the Treatment of Multiple Myeloma. Small 2023, e2301748.

12. Wu, D.; Zhao, L.; Sui, B.; Tan, L.; Lu, L.; Mao, X.; Liao, G.; Shi, S.; Cao, Y.; Yang, X.; Kou, X.*, An Appearance Data-Driven Model Visualizes Cell State and Predicts Mesenchymal Stem Cell Regenerative Capacity. Small Methods 2022, e2200087.

13. Ou, Q.; Tan, L.; Shao, Y.; Lei, F.; Huang, W.; Yang, N.; Qu, Y.; Cao, Z.; Niu, L.; Liu, Y.; Kou, X.; Shi, S., Electrostatic Charge-Mediated Apoptotic Vesicle Biodistribution Attenuates Sepsis by Switching Neutrophil NETosis to Apoptosis. Small 2022, e2200306.

14. Kou, X.; Liu, J.; Wang, D.; Yu, M.; Li, C.; Lu, L.; Chen, C.; Liu, D.; Yu, W.; Yu, T.; Liu, Y.; Mao, X.; Naji, A.; Cai, T.; Sun, L.; Shi, S.*, Exocrine pancreas regeneration modifies original pancreas to alleviate diabetes in mouse models. Sci Transl Med 2022, 14 (656), eabg9170.

15. He, Y.; Qu, Y.; Meng, B.; Huang, W.; Tang, J.; Wang, R.; Chen, Z.; Kou, X.; Shi, S., Mesenchymal stem cells empower T cells in the lymph nodes via MCP-1/PD-L1 axis. Cell Death Dis 2022, 13 (4), 365.

18. He, D.; Liu, F.; Cui, S.; Jiang, N.; Yu, H.; Zhou, Y.; Liu, Y.; Kou, X.*, Mechanical load-induced H2S production by periodontal ligament stem cells activates M1 macrophages to promote bone remodeling and tooth movement via STAT1. Stem cell research & therapy 2020, 11 (1), 112.