林正梅 | 中山大学附属口腔医院

林正梅

教授主任医师博士生导师硕士生导师

导师简介

【学位 / 学历】

博士 / 博士研究生

【学术简历】

1984-1990 中山医科大学口腔临床医学专业获学士学位

1995-1998 中山医科大学口腔临床医学专业获硕士学位

2004-2007 中山大学口腔临床医学专业获博士学位

【研究方向】

口颌系统炎性疾病的免疫应答与修复机制、微环境重塑及组织再生策略研究

【主持课题】

1. 2023年：《3D培养牙源性干细胞外泌体标准化制备体系构建及其在牙槽骨再生中的应用研究》，广东省科技厅国际科技合作项目，50万

2. 2021年：《牙髓干细胞外泌体miR-1246重塑衰老微环境中巨噬细胞抗炎表型促进牙槽骨损伤修复的机制》，国家自然科学基金面上项目，55万

【发表论文】

1.Zhengmei Lin#, Dingming Huang#, Shuheng Huang#, Zhi Chen, Qing Yu, Benxiang Hou, Lihong Qiu, Wenxia Chen, Jiyao Li, Xiaoyan Wang, Zhengwei Huang, Jinhua Yu, Jin Zhao, Yihuai Pan, Shuang Pan, Deqin Yang, Weidong Niu, Qi Zhang, Shuli Deng, Jingzhi Ma, Xiuping Meng, Jian Yang, Jiayuan Wu, Lan Zhang, Jin Zhang, Xiaoli Xie, Jinpu Chu, Kehua Que, Xuejun Ge, Xiaojing Huang, Zhe Ma, Lin Yue, Xuedong Zhou, Junqi Ling*. Expert consensus on intentional tooth replantation. International Journal of Oral Science. (2025) 17:16.

2.Xiaotong Guo#, Zhu Huang#, Fan Wu#, Wentao Jiang, Yiyang Li, Tao Wang, Simon D Tran, Zhengmei Lin, Xinyun Su. Exosomes of human adipose stem cells mitigate irradiation injury to salivary glands by inhibiting epithelial-mesenchymal transition through miR-199a-3p targeting Twist1 and regulating TGFβ1/Smad3 pathway. Theranostics, 2025, 15(5): 1622-41.

3.Peimeng Zhan#, Zhu Huang#, Zhuo Xie, Xinfang Zhang, Zongshan Shen, Lingling Chen, Shuheng Huang, Qiting Huang, Zhengmei Lin, Runfu Wang. FoxO1 mediates odontoblast differentiation of hDPSCs via B cell-derived ANGPTL1 in dental caries: A laboratory investigation. Int Endod J. 2025 May;58(5):757-775.

4. Hui Liu, Zhuo Xie, Xianling Gao, Linhesheng Wei, Mengdi Li, Zhengmei Lin, Xin Huang. Lysosomal dysfunction-derived autophagy impairment of gingival epithelial cells in diabetes-associated periodontitis with altered protein acetylation.Cell Signal. 2024 Sep:121:111273.

5. Yiyang Li# Xiaotong Guo#, Peimeng Zhan, Shuheng Huang , Jiayao Chen , Yujie Zhou, Wentao Jiang, Lingling Chen, Zhengmei Lin. TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2. Inflammation. 2024 Dec;47(6):2041-2056.

6. Xin Huang#, Linhesheng Wei#, Mengdi Li, Yong Zhang, Shuhong Kuang, Zongshan Shen, Hui Liu, Zhengmei Lin*. Diabetic Macrophage Exosomal miR-381-3p Inhibits Epithelial Cell Autophagy Via NR5A2. International Dental Journal. 2024 Aug;74(4):823-835.

7. Jiayao Chen #, Shuhong Kuang #, Jietao Cen, Yong Zhang, Zongshan Shen, Wei Qin, Qiting Huang, Zifeng Wang, Xianling Gao, Fang Huang, Zhengmei Lin. Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure. International Journal of Oral Science. 2024 May 22;16(1):41.

8. Zelin Liang#, Junda Li#, Hongkun Lin, Sien Zhang, Fan Liu, Zilong Rao, Jiaxin Chen, Yuwen Feng, Kexin Zhang, Daping Quan, Zhengmei Lin, Ying Bai, Qiting Huang*. Understanding the multi-functionality and tissue-specificity of decellularized dental pulp matrix hydrogels for endodontic regeneration. Acta biomaterialia. 2024;181:202-221.

9. Zhuo Xie, Peimeng Zhan, Xinfang Zhang, Shuheng Huang, Xuetao Shi, Zhengmei Lin, Xianling Gao*. Providing biomimetic microenvironment for pulp regeneration via hydrogel-mediated sustained delivery of tissue-specific developmental signals. Mater Today Bio. 2024 May 27:26:101102.

10. Zhuo Xie#, Wentao Jiang#, Hui Liu, Lingling Chen, Chengkai Xuan, Zhenxing Wang, Xuetao Shi, Zhengmei Lin, Xianling Gao*.Antimicrobial Peptide- and Dentin Matrix-Functionalized Hydrogel for Vital Pulp Therapy via Synergistic Bacteriostasis, Immunomodulation, and Dentinogenesis. Adcanced Healthcare Materials. 2024 Mar 2:e2303709.

11.Wentao Jiang#, Zhuo Xie#, Shuheng Huang , Qiting Huang, Lingling Cheng, Xianling Gao, Zhengmei Lin*. Targeting cariogenic pathogens and promoting competitiveness of commensal bacteria with a novel pH-responsive antimicrobial peptide. Journal of Oral Microbiology. 2023;15(1): 2159375

12. Zongshan Shen#, Shuhong Kuang#, Yong Zhang#, Jiayao Chen, Shuting Wang, Congfei Xu, Yunjia Huang, Min Zhang, Shuheng Huang, Jun Wang, ChuanJiang Zhao, Zhengmei Lin, Xuetao Shi, Bin Cheng*. Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nhigh astrocytes in the hippocampus. The Innovation. 2024 Jan, 5(1).

13. Peimeng Zhan#, Xinfang Zhang#, Zhuo Xie#, Lingling Chen, Shuheng Huang, Qiting Huang, Zhengmei Lin, Runfu Wang. Nicotinamide riboside modulates HIF-1 signaling to maintain and enhance odontoblastic differentiation in human dental pulp stem cells. Stem Cells, sxad083.

14.Mingmei Yang#, Zongshan Shen#, Xinfang Zhang#, Zhi Song, Yong Zhang, Zhengmei Lin, Lingling Chen. Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway. Free Radical Biology and Medicine. .2023 Aug22;208:334-347.

15. Jinyan Wu#; Yaxian Huang#; Chi Zhang, Lingling Chen, Zhengmei Lin, Zhi Song. Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes. iScience. 2023, 11;26(9):107618.

16 Yaxian Huang#, Jinyan Wu#, Chi Zhan#, Rong Liu#, Zhaocai Zhou, Xin Huang , Yaguang Tian, Zhengmei Lin, Zhi Song. TRAF-STOP alleviates osteoclasto-genesis in periodontitis. Frontiers in Pharmacology. 2023,15:14:1119847.

17. Fangcao Lei, Zhiyuan Huang, Qianmin Ou, Jiaqi Li, Manqing Liu, Lan Ma, Lingping Tan, Zhengmei Lin, Xiaoxing Kou. Apoptotic vesicles rejuvenate mesenchymal stem cells via Rab7-mediated autolysosome formation and alleviate bone loss in aging mice. Nano Research. 2023,16(1):822-833.

18. Haijun Fu#, Jiayu Yang#, Zongshan Shen, Yong Zhang, Shuhong Kuang, Lifeng Li, Zhengmei Lin, Xuetao Shi. Antibacterial, wet adhesive, and healingpromoting nanosheets for the treatment of oral ulcers. Biomaterials Science. 2023, 2;11(9):3214-3226.

19. Mengdi Li#,Shuheng Huang#, Yong Zhang, Zhi Song, Haijun Fu, Zhengmei Lin, Xin Huang. Regulation of the unfolded protein response transducer IRE1α by SERPINH1 aggravates periodontitis with diabetes mellitus via prolonged ER stress. Cell Signal. 2022, 91:110241.

20.Yong Zhang#, Jiayao Chen#, Haijun Fu#, Shuhong Kuang, Feng He, Min Zhang, Zongshan Shen, Wei Qin, Zhengmei Lin, Shuheng Huang. Exosomes derived from 3D-cultured MSCs improve therapeutic effects inperiodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium. International Journal of Oral Science.2021;13(1):43.

21. Shuhong Kuang#, Feng He#, Guihua Liu#, Xiangzhou Sun, Jian Dai, Ani Chi, Yali Tang, Zhuoran Li, Yong Gao, Chunhua Deng, Zhengmei Lin, Haipeng Xiao, Min Zhang*. CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis. Biomaterials. 2021;275:120963.

22. Xianling Gao#, Meiliang Guan#, Xuemin Liu#, Hockin H. K. Xu, Qiting Huang, Lingling Chen, Shuheng Huang, Yin Xiao, Xuetao Shi, Zhengmei Lin*. Sustained delivery of growth factors and alendronate using partially demineralized dentin matrix for endogenous periodontal regeneration. Applied Materials Today.2021,100922.

23. Zongshan Shen#, Shuhong Kuang#, Min Zhang#, Xin Huang, Jiayao Chen, Meiliang Guan, Wei Qin, Hockin HK Xu, Zhengmei Lin*. Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties. Cellular & Molecular Immunology. 2021; 18(9): 2224-2235.

24. Minxia Liu, Lingling Chen, Jinyan Wu, Zhengmei Lin, Shuheng Huang. Long noncoding RNA MEG3 expressed in human dental pulp regulates LPS-Induced inflammation and odontogenic differentiation in pulpitis. Exp Cell Res. 2021;400(2):112495.

25. Qiting Huang#, Zelin Liang, Junda Li, Ying Bai, Jingwei He, Zhengmei Lin*. Size Dependence of Particulate Calcium Phosphate Fillers in Dental Resin Composites. ACS Omega. 2021;6(50):35057-35066.

26. Lingling Chen, Morgan Carlton, Xiaodan Chen, Navdeep Kaur, Hollie Ryan, Tony J Parker, Zhengmei Lin, Yin Xiao, Yinghong Zhou*. Effect of fibronectin, FGF-2, and BMP4 in the stemness maintenance of BMSCs and the metabolic and proteomic cues involved. Stem Cell Research & Therapy. 2021;6;12(1):165.

27. Zhuo Xie#, Zongshan Shen#, Peimeng Zhan, Jiayu Yang, Qiting Huang, Shuheng Huang, Lingling Chen, Zhengmei Lin. Functional Dental Pulp Regeneration: Basic Research and Clinical Translation. International Journal of Molecular Sciences. 2021 Aug 20;22(16):8991.

【参编教材与论著】

1. 2025年主编《2025口腔内科学同步习题集》人民卫生出版社 9787117356046

2. 2020年副主编《口腔基础研究导论》人民卫生出版社 9787117293259

3. 2024年副主编《牙体牙髓病多学科诊疗病例精粹》人民卫生出版社 978-7-117-35991-7

4. 副主编《牙体牙髓病学》第六版电子板人民卫生出版社

【获奖及学术荣誉】

1. 2023年高等学校科学研究优秀成果奖科学技术进步奖二等奖

2. 2023年宝钢优秀教师

3. 2022年广东省医师奖

4. 2022年广东省教育教学成果奖一等奖

5. 2021年广东省本科高校课程思政改革示范团队

【社会兼职】

1. 中华口腔医学会口腔医学教育专委会常务委员

2. 中华口腔医学会老年口腔医学委员会常务委员

3. 中华口腔医学会牙体牙髓病学专业委员会常务委员

4. 广东省口腔医学会牙体牙髓病学专业委员会副主任委员

5. 广东省口腔医师协会会长

6. 广东省口腔医学会常务理事

【联系方式】

地址：广州市陵园西路56号

邮箱：linzhm@mail.sysu.edu.cn

【研究方向】

口颌系统炎性疾病的免疫应答与修复机制、微环境重塑及组织再生 策略研究

【主持课题】

【发表论文】

4. Hui Liu, Zhuo Xie, Xianling Gao, Linhesheng Wei, Mengdi Li, Zhengmei Lin*, Xin Huang*. Lysosomal dysfunction-derived autophagy impairment of gingival epithelial cells in diabetes-associated periodontitis with altered protein acetylation.Cell Signal. 2024 Sep:121:111273.

5. Yiyang Li# Xiaotong Guo#, Peimeng Zhan, Shuheng Huang , Jiayao Chen , Yujie Zhou, Wentao Jiang, Lingling Chen*, Zhengmei Lin*. TRPV1 Regulates Proinflammatory Properties of M1 Macrophages in Periodontitis Via NRF2. Inflammation. 2024 Dec;47(6):2041-2056.

6. Xin Huang#, Linhesheng Wei#, Mengdi Li, Yong Zhang, Shuhong Kuang, Zongshan Shen, Hui Liu, Zhengmei Lin*. Diabetic Macrophage Exosomal miR-381-3p Inhibits Epithelial Cell Autophagy Via NR5A2. International Dental Journal. 2024 Aug;74(4):823-835.

9. Zhuo Xie, Peimeng Zhan, Xinfang Zhang, Shuheng Huang, Xuetao Shi*, Zhengmei Lin*, Xianling Gao*. Providing biomimetic microenvironment for pulp regeneration via hydrogel-mediated sustained delivery of tissue-specific developmental signals. Mater Today Bio. 2024 May 27:26:101102.

11.Wentao Jiang#, Zhuo Xie#, Shuheng Huang , Qiting Huang, Lingling Cheng, Xianling Gao, Zhengmei Lin*. Targeting cariogenic pathogens and promoting competitiveness of commensal bacteria with a novel pH-responsive antimicrobial peptide. Journal of Oral Microbiology. 2023;15(1): 2159375

13. Peimeng Zhan#, Xinfang Zhang#, Zhuo Xie#, Lingling Chen, Shuheng Huang, Qiting Huang, Zhengmei Lin*, Runfu Wang*. Nicotinamide riboside modulates HIF-1 signaling to maintain and enhance odontoblastic differentiation in human dental pulp stem cells. Stem Cells, sxad083.

14.Mingmei Yang#, Zongshan Shen#, Xinfang Zhang#, Zhi Song, Yong Zhang, Zhengmei Lin*, Lingling Chen*. Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway. Free Radical Biology and Medicine. .2023 Aug22;208:334-347.

15. Jinyan Wu#; Yaxian Huang#; Chi Zhang, Lingling Chen, Zhengmei Lin*, Zhi Song*. Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis with diabetes. iScience. 2023, 11;26(9):107618.

16 Yaxian Huang#, Jinyan Wu#, Chi Zhan#, Rong Liu#, Zhaocai Zhou, Xin Huang , Yaguang Tian, Zhengmei Lin*, Zhi Song*. TRAF-STOP alleviates osteoclasto-genesis in periodontitis. Frontiers in Pharmacology. 2023,15:14:1119847.

17. Fangcao Lei, Zhiyuan Huang, Qianmin Ou, Jiaqi Li, Manqing Liu, Lan Ma, Lingping Tan, Zhengmei Lin*, Xiaoxing Kou*. Apoptotic vesicles rejuvenate mesenchymal stem cells via Rab7-mediated autolysosome formation and alleviate bone loss in aging mice. Nano Research. 2023,16(1):822-833.

18. Haijun Fu#, Jiayu Yang#, Zongshan Shen, Yong Zhang, Shuhong Kuang, Lifeng Li, Zhengmei Lin*, Xuetao Shi*. Antibacterial, wet adhesive, and healingpromoting nanosheets for the treatment of oral ulcers. Biomaterials Science. 2023, 2;11(9):3214-3226.

19. Mengdi Li#,Shuheng Huang#, Yong Zhang, Zhi Song, Haijun Fu, Zhengmei Lin*, Xin Huang*. Regulation of the unfolded protein response transducer IRE1α by SERPINH1 aggravates periodontitis with diabetes mellitus via prolonged ER stress. Cell Signal. 2022, 91:110241.

24. Minxia Liu, Lingling Chen, Jinyan Wu, Zhengmei Lin*, Shuheng Huang*. Long noncoding RNA MEG3 expressed in human dental pulp regulates LPS-Induced inflammation and odontogenic differentiation in pulpitis. Exp Cell Res. 2021;400(2):112495.