【学位 / 学历】

博士 / 博士研究生

【学术简历】

1988.09-1993.07  四川大学华西口腔医学院口腔医学专业获学士学位

1993.09-1996.06  上海交通大学口腔医学院口腔医学专业获硕士学位

1998.03-2000.03  香港大学牙医学院保存齿科学专业获硕士学位

2004.09-2007.06  中山大学光华口腔医学院口腔医学专业获博士学位

【研究方向】

1. 牙髓损伤修复的机制研究

2. 牙髓病和根尖周病的病因与防治

3. 龋病病因与微生态防治

【主持课题】

1. 2024-2027年：《硅酸钙活化的小细胞外囊泡诱导巨噬细胞线粒体自噬免疫调控牙髓炎的机制研究》，国家自然科学基金项目，48万

2. 2020-2023年：《牙囊干细胞外泌体传递效应miRNA调控牙髓炎免疫的机制及智能递释体系的构建》，国家自然科学基金项目，57万

3. 2020-2022年：《活髓保存治疗防控恒牙龋源性牙髓损伤的随机对照前瞻性研究》，广东省财政高水平医院重点科研培育项目，100万

4. 2017-2020年：《牙囊干细胞旁分泌重塑牙髓炎症微环境的免疫调节机制研究》，国家自然科学基金项目，58万

5. 2017-2021年：《牙髓干细胞免疫调控损伤牙髓命运转换的机制研究》，省自然重大基础研究培育项目，100万

【发表论文】

1. Tian J, Lou Y, Li M, Duan Y, Liu H, Chen C, Qiu Y, Chen W, Pang C, Xiong Y, Shen Y*, Wei X*. Dental follicle stem cell-derived small extracellular vesicles ameliorate pulpitis by reprogramming macrophage metabolism. Bioactive Materials 2025; 51:179–96.

2. Wang B, Li W, Huang W, Li X, Li J, Shi S, Mao X*, Wei X*. Multiple cell death modalities and immune response in pulpitis. Int Endod J 2025; 58(1): 111–27.

3. Huang Q, Zeng Q, Wang X, Wang X, Huang Q, Zheng J, Peng Z, Lin Z, Mai S, Wei X. Customized Virtual Simulation Platform for Practicing Root Canal Filling in Undergraduate Preclinical Course. J Dent Educ 2025: e13901.

4. Zhang Y, Li X, Wei X, Xiao J, Zhang Q, Mai S. A pilot study on the application of a digital dental teaching evaluation system in Class II cavity preparation teaching. BMC Oral Health 2025; 25(1): 372.

5. Wang H, Xu X, Bian Z, Liang J, Chen Z, Hou B, Qiu L, Chen W, Wei X, Hu K, Wang Q, Wang Z, Li J, Huang D, Wang X, Huang Z, Meng L, Zhang C, Xie F, Yang D, Yu J, Zhao J, Pan Y, Pan S, Yang D, Niu W, Zhang Q, Deng S, Ma J, Meng X, Yang J, Wu J, Du Y, Ling J, Yue L, Zhou X, Yu Q. Expert consensus on apical microsurgery. Int J Oral Sci 2025; 17(1): 2.

6. Xia L, Zhou C, Mei P, Jin Z, He H, Wang L, Bai Y, Chen L, Li W, Wang J, Hu M, Song J, Cao Y, Liu Y, Hou B, Wei X, Niu L, Lu H, Ma W, Wang P, Zhang G, Guo J, Li Z, Lu H, Ren L, Xu L, Wu X, Lu Y, Hu J, Yue L, Zhang X, Fang B. Expert consensus on the prevention and treatment of enamel demineralization in orthodontic treatment. Int J Oral Sci 2025; 17(1): 13.

7. Zhang L, Lin C, Chen Z, Yue L, Yu Q, Hou B, Ling J, Liang J, Wei X, Chen W, Qiu L, Li J, Niu Y, Lin Z, Cheng L, He W, Wang X, Huang D, Huang Z, Niu W, Zhang Q, Zhang C, Yang D, Yu J, Zhao J, Pan Y, Ma J, Deng S, Xie X, Meng X, Yang J, Zhou X, Chen Z. Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis. Int J Oral Sci 2025; 17(1): 4.

8. Liu J, Kang J, Zou T, Hu M, Zhang Y, Lin S, Liang Y, Zhong J, Zhao Y, Wei X, Zhang C. Functional cobalt-doped hydrogel scaffold enhances concurrent vascularization and neurogenesis. J Nanobiotechnology 2025; 23(1): 179.

9. Li M, Tian J, Yu K, Liu H, Yu X, Wang N, Gong Q*, Li K*, Shen Y*, Wei X*. A ROS-responsive hydrogel incorporated with dental follicle stem cell-derived small extracellular vesicles promotes dental pulp repair by ameliorating oxidative stress. Bioact Mater 2024; 36: 524–40.

10. Huang W, Wang B, Ou Q, Zhang X, He Y, Mao X, Wei X*, Kou X*. ASC-expressing pyroptotic extracellular vesicles alleviate sepsis by protecting B cells. Mol Ther 2024; 32(2): 395–410.

11. Cui C, Lu C, Cai Y, Xiong Y, Duan Y, Lan K, Fan Y, Zhou X*, Wei X*. PTH1R Suppressed Apoptosis of Mesenchymal Progenitors in Mandibular Growth. Int J Mol Sci 2024; 25(23).

12. Zeng Q, Chen M, Zheng S, Wei X*, Liu H*. Efficacy of vital pulp therapy for carious pulp injury in permanent teeth: a study protocol for an open-label randomized controlled noninferiority trial. Trials 2024; 25(1): 700.

13. Chen Z, Lu Y, Xu Z, Wu L, Wei X*, Cai Y*. Evaluation of a Burkholderia ambifaria strain from plants as a novel promising probiotic in dental caries management. J Oral Microbiol 2024; 16(1): 2420612.

14. Huang D, Wang X, Liang J, Ling J, Bian Z, Yu Q, Hou B, Chen X, Li J, Ye L, Cheng L, Xu X, Hu T, Wu H, Guo B, Su Q, Chen Z, Qiu L, Chen W, Wei X, Huang Z, Yu J, Lin Z, Zhang Q, Yang D, Zhao J, Pan S, Yang J, Wu J, Pan Y, Xie X, Deng S, Huang X, Zhang L, Yue L, Zhou X. Expert consensus on difficulty assessment of endodontic therapy. Int J Oral Sci 2024; 16(1): 22.

15. Huang X, Lou Y, Duan Y, Liu H, Tian J, Shen Y*, Wei X*. Biomaterial scaffolds in maxillofacial bone tissue engineering: A review of recent advances. Bioact Mater 2024; 33: 129–56.

16. Zou X, Zheng X, Liang Y, Zhang C, Fan B, Liang J, Ling J, Bian Z, Yu Q, Hou B, Chen Z, Wei X, Qiu L, Chen W, He W, Xu X, Meng L, Zhang C, Chen L, Deng S, Lei Y, Xie X, Wang X, Yu J, Zhao J, Shen S, Zhou X, Yue L. Expert consensus on irrigation and intracanal medication in root canal therapy. Int J Oral Sci 2024; 16(1): 23.

17. Ye L, Li S, Li C, Wang C, Wei X, Zhou W, Du Y. Pulp calcification identification on cone beam computed tomography: an artificial intelligence pilot study. BMC Oral Health 2024; 24(1): 1132.

18. Xu X, Zheng X, Lin F, Yu Q, Hou B, Chen Z, Wei X, Qiu L, Wenxia C, Li J, Chen L, Wang Z, Wu H, Lu Z, Zhao J, Liang Y, Zhao J, Pan Y, Pan S, Wang X, Yang D, Ren Y, Yue L, Zhou X. Expert consensus on endodontic therapy for patients with systemic conditions. Int J Oral Sci 2024; 16(1): 45.

19. Zeng Q, Zhou C, Li M, Qiu Y, Wei X*, Liu H*. Concentrated growth factor combined with iRoot BP Plus promotes inflamed pulp repair: an in vitro and in vivo study. BMC Oral Health 2023; 23(1): 225.

20. Wei X#, Du Y#, Zhou X, Yue L, Yu Q, Hou B, Chen Z, Liang J, Chen W, Qiu L, Huang X, Meng L, Huang D, Wang X, Tian Y, Tang Z, Zhang Q, Miao L, Zhao J, Yang D, Yang J, Ling J. Expert consensus on digital guided therapy for endodontic diseases. Int J Oral Sci 2023; 15(1): 54.

21. Liu B, Zhou X, Yue L, Hou B, Yu Q, Fan B, Wei X, Qiu L, Huang Z, Xia W, Sun Z, Wang H, Meng L, Peng B, Zhang C, Deng S, Lu Z, Yang D, Hou T, Jiang Q, Xie X, Liu X, Li J, Wang Z, Lyu H, Xue M, Ge J, Du Y, Zhao J, Liang J. Experts consensus on the procedure of dental operative microscope in endodontics and operative dentistry. Int J Oral Sci 2023; 15(1): 43.

22. Qiu Y, Tian J, Kong S, Feng Y, Lu Y, Su L, Cai Y, Li M, Chang J*, Yang C*, Wei X*. SrCuSi(4) O(10) /GelMA Composite Hydrogel-Mediated Vital Pulp Therapy: Integrating Antibacterial Property and Enhanced Pulp Regeneration Activity. Adv Healthc Mater 2023; 12(24): e2300546.

23. Tian J, Chen W, Xiong Y, Li Q, Kong S, Li M, Pang C, Qiu Y, Xu Z, Gong Q*, Wei X*. Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis. Bioact Mater 2023; 22: 326–42.

24. Hong H, Zeng K, Zhou C, Chen X, Xu Z, Li M, Liu L, Zeng Q, Tao Q*, Wei X*. The pluripotent factor OCT4A enhances the self-renewal of human dental pulp stem cells by targeting lncRNA FTX in an LPS-induced inflammatory microenvironment. Stem Cell Res Ther 2023; 14(1): 109.

25. Wei X, Yang M, Yue L, Huang D, Zhou X, Wang X, Zhang Q, Qiu L, Huang Z, Wang H, Meng L, Li H, Chen W, Zou X, Ling J. Expert consensus on regenerative endodontic procedures. Int J Oral Sci 2022; 14(1): 55.

26. Fan Y, Cui C, Rosen CJ, Sato T, Xu R, Li P, Wei X, Bi R, Yuan Q, Zhou C. Klotho in Osx(+)-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair. Signal Transduct Target Ther 2022; 7(1): 155.

27. Wei X, Mai S. New Materials and Their Applications: Perspectives in Restorative Dentistry and Endodontics. Materials (Basel) 2022; 15(17).

28. Lu Y, Lei L, Deng Y, Zhang H, Xia M, Wei X, Yang Y, Hu T. RNase III coding genes modulate the cross-kingdom biofilm of Streptococcus mutans and Candida albicans. Front Microbiol 2022; 13: 957879.

29. Yang R, Liu T, Pang C, Cai Y, Lin Z, Guo L*, Wei X*. The Regulatory Effect of Coaggregation Between Fusobacterium nucleatum and Streptococcus gordonii on the Synergistic Virulence to Human Gingival Epithelial Cells. Front Cell Infect Microbiol 2022; 12: 879423.

30. Yang X, Tian J, Li M, Chen W, Liu H, Wang Z, Haapasalo M, Shen Y*, Wei X*. Biocompatibility of a New Calcium Silicate-Based Root Canal Sealer Mediated via the Modulation of Macrophage Polarization in a Rat Model. Materials (Basel) 2022; 15(5).

31. Yang R, Tian J, Huang X, Lei S, Cai Y, Xu Z, Wei X. A comparative study of dentinal tubule penetration and the retreatability of EndoSequence BC Sealer HiFlow, iRoot SP, and AH Plus with different obturation techniques. Clin Oral Investig 2021; 25(6): 4163–73.

32. Liu T, Yang R, Zhou J, Lu X, Yuan Z, Wei X, Guo L. Interactions Between Streptococcus gordonii and Fusobacterium nucleatum Altered Bacterial Transcriptional Profiling and Attenuated the Immune Responses of Macrophages. Front Cell Infect Microbiol 2021; 11: 783323.

33. Tian J, Kou X, Wang R, Jing H, Chen C, Tang J, Mao X, Zhao B, Wei X*, Shi S*. Autophagy controls mesenchymal stem cell therapy in psychological stress colitis mice. Autophagy 2021; 17(9): 2586–603.

34. Yang R, Han Y, Liu Z, Xu Z, Liu H*, Wei X*. Comparison of the efficacy of laser-activated and ultrasonic-activated techniques for the removal of tricalcium silicate-based sealers and gutta-percha in root canal retreatment: a microtomography and scanning electron microscopy study. BMC Oral Health 2021; 21(1): 275.

35. Peng Z, Liu L, Zhang W, Wei X. Pluripotency of Dental Pulp Cells and Periodontal Ligament Cells Was Enhanced through Cell-Cell Communication via STAT3/Oct-4/Sox2 Signaling. Stem Cells Int 2021; 2021: 8898506.

36. Wang N, Yu K-K, Li K, Li M-J, Wei X*, Yu X-Q*. Plant-Inspired Multifunctional Fluorescent Hydrogel: A Highly Stretchable and Recoverable Self-Healing Platform with Water-Controlled Adhesiveness for Highly  Effective Antibacterial Application and Data Encryption-Decryption. ACS Appl Mater Interfaces 2020; 12(52): 57686–94.

37. Zheng J, Kong Y, Hu X, Li Z, Li Y, Zhong Y, Wei X*, Ling J*. MicroRNA-enriched small extracellular vesicles possess odonto-immunomodulatory properties for modulating the immune response of macrophages and promoting  odontogenesis. Stem Cell Res Ther 2020; 11(1): 517.

38. Hong H, Chen X, Li K, Wang N, Li M, Yang B, Yu X*, Wei X*. Dental follicle stem cells rescue the regenerative capacity of inflamed rat dental pulp through a paracrine pathway. Stem Cell Res Ther 2020; 11(1): 333.

39. 刘红艳,郑思怡,韦曦.不可复性牙髓炎的活髓保存治疗：生物学基础与临床进展.口腔医学,2024,44(06):401-407.

40. 韦曦,曾凯.数字化导航技术在牙髓根尖周病诊疗中的应用进展及临床决策.牙体牙髓牙周病学杂志,2024,29(06):311-319.

41. 崔晨,权晶晶,韦曦.临床导向的机用镍钛预备器械研究新进展.华西口腔医学杂志,2024,42(06):699-705.

42. 杜宇,麦穗,龚启梅,权晶晶,韦曦. PICO循证医学原则在牙体牙髓病科住院医师病例报告中的应用效果评价.中华医学教育探索杂志,2024,23(08):1139-1143.

43. 韦曦,蓝凯文.牙隐裂的诊断流程与临床干预策略.中华口腔医学杂志,2024,59(08):863-870.

44. 蔡艳玲,权晶晶,田俊,黄湘雅,韦曦.显微根管治疗线上线下混合式教学的应用调查.中华口腔医学杂志,2024,59(06):610-616.

45. 刘红艳,韦曦,凌均棨.人工智能在龋病诊疗中的应用与探索.中华口腔医学杂志,2024,59(01):37-44.

46. 刘红艳,韦曦,凌均棨.根管封药的应用现状及研究进展.中华口腔医学研究杂志（电子版）,2023,17(2):69-74.

47. 龚启梅,凌均棨,韦曦.氟牙症发生机制的研究新进展.中华口腔医学杂志,2023,58(3):217-223.

48. 黄湘雅,韦曦,凌均棨.数字化技术在牙发育异常诊疗中的应用.中华口腔医学杂志,2023,58(1):31-39.

49. 张琦,陈灏,王若旬,亓益品,韦曦,高燕,麦穗.整体思维培养在牙体牙髓病科实习教学中的实践.中华医学教育探索杂志,2022,21(12):1700-1704.

50. 龚启梅,麦穗,权晶晶,黄丽佳,刘红艳,韦曦.牙体牙髓病学智慧课堂教学模式的建设和应用初探.中华口腔医学杂志,2022,57(12):1237-1242.

51. 周灿,曾倩,韦曦.浓缩生长因子在活髓保存治疗中的应用前景.国际口腔医学杂志,2022,49(6):684-689.

52. 黄湘雅,张辉,韦曦.数字化导板技术在靶向显微根尖手术中的应用一例.中国口腔医学继续教育杂志,2022,25(2):65-71.

53. 权晶晶,龚启梅,郭敏,卢嘉蕊,麦穗,古丽莎,韦曦.新冠疫情防控期间口腔医学在线教育培训的应用效果分析.医学教育研究与实践,2022,30(1):30-34.

54. 杨小倩,杨蕊琦,田俊,韦曦.以生物陶瓷材料为封闭剂的单尖充填法应用现状与展望.中华口腔医学杂志, 2022,57(04):424-429.

55. 杜宇,韦曦,凌均棨.动静态导航技术在牙髓根尖周病治疗中的应用及展望.中华口腔医学杂志, 2022,57(1):23-30.

56. 陈伟洋,田俊,韦曦.硅离子在骨组织修复再生领域的作用.中华口腔医学研究杂志(电子版),2021,15(06):375-381.

57. 麦穗,韦曦,凌均棨.复合树脂充填材料的研发策略和进展.中华口腔医学杂志, 2021,56:51-56.

58. 王奔,许喆桢,韦曦.数字化微创技术在牙髓根尖周病学中的应用与进展.国际口腔医学杂志, 2021,48:110-118.

59. 黄湘雅,蔡艳玲,韦曦.显微根尖手术的全周期管理.口腔疾病防治, 2021,29:649-655.

60. 郭敏,麦穗,卢嘉蕊,韦曦.橡皮障隔离下显微根管治疗教学模具的制备与应用.中华口腔医学研究杂志（电子版）, 2021,15:241-244.

61. 曾凯密,韦曦,黄湘雅,伍婉翠.不同镍钛系统结合触控启动技术预备模拟弯曲根管的成形效果研究.中华口腔医学研究杂志（电子版）, 2021,15:6-12.

62. 郑健茂,刘佳,韦曦,麦穗.以“光华杯”口腔临床技能竞赛为契机不断提高牙体牙髓病学实践教学质量.中华口腔医学研究杂志(电子版),2020,14(03):181-186.

63. 古丽莎,韦曦,凌均棨.氟牙症的病因、诊断与防治.中华口腔医学杂志,2020(05):296-301.

64. 权晶晶,刘红艳,麦穗,黄奕华,许喆桢,雷书翔,韩雨晴,韦曦.口腔手术显微镜在牙体牙髓病学实验教学中的应用.中华医学教育杂志,2020,40(08):615-618.

65. 古丽莎,龚启梅,周玉竹,韦曦.新型冠状病毒肺炎疫情期间对急性牙痛临床诊疗工作的防控建议.中华口腔医学研究杂志·电子版,2020;14(1):9-13.

66. 周玉竹,龚启梅,韦曦,古丽莎.新型冠状病毒肺炎疫情期间口腔治疗喷溅操作中气溶胶污染的管理与防控建议.广东医学,2020:1-5.

【参编教材与论著】

1. 2025年 副主编《显微牙髓治疗学》第2版 人民卫生出版社 9787117376976

2. 2024年 主编《牙体牙髓病临床治疗新技术》 科学技术文献出版社 9787523507155

3. 2024年 副主编《牙体牙髓病多学科诊疗病例精粹》 人民卫生出版社 9787117359917

4. 2020年 编委《牙体牙髓病学》第5版 人民卫生出版社 9787117293709

5. 2020年 主编《中山大学光华口腔医学院·附属口腔医院牙体牙髓病病例精解》 科学技术文献出版社 9787518961115

【获奖及学术荣誉】

1. 2022年 广东省科学技术奖二等奖（第1完成人）

2. 2022年 广东省医院协会医院管理创新奖（第1完成人）

3. 2022年 广东省教育教学成果奖一等奖（第5完成人）

4. 2020年 广东省教育教学成果一等奖（第1完成人）

5. 2020年 校级教学成果特等奖（第1完成人）

【社会兼职】

1. 中华口腔医学会牙体牙髓病学专业委员会常委

2. 广东省口腔医学会牙体牙髓病学专业委员会主任委员

3. 广东省口腔医学会副秘书长

4. 国际牙医师学院院士

5. 国家医师资格考试口腔类别试题开发专委会委员

6. 广东省专业学位研究生教育指导委员会主任委员

7. JOE Scientific Advisory Board member委员

8. 《中华口腔医学杂志》编委

9. 《牙体牙髓牙周病学杂志》副主编

10. 《华西口腔医学杂志》编委

11. 《中国实用口腔科杂志》编委

12. 《Chinese Journal of Dental Research》编委

13. 《上海口腔医学》编委

14. 《中华口腔医学研究杂志(电子版 ) 》编委

15. 《上海口腔医学》编委

16. 《中华口腔医学研究杂志（电子版）》编委

【联系方式】

地址：广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院（510055）

电话：020-83880049

邮箱：weixi@mail.sysu.edu.cn