【学位 / 学历】

博士 / 博士研究生

【学术简历】

1988-1993  武汉大学口腔医学专业获学士学位

1993-1996  武汉大学生物化学专业获硕士学位

2000-2003  武汉大学口腔临床医学专业获博士学位

【研究方向】

1. 牙髓根尖周病的致病机制

2. 牙髓细胞分化的表观遗传调控机制

3. 牙髓根尖周病疑难病例的临床诊治

【主持课题】

1. 2023年：《NAT10调控牙髓炎中巨噬细胞HIF-1α/乳酸轴影响牙髓干细胞分化的机制研究》，国家自然科学基金面上项目48万

2. 2024年：《N-乙酰转移酶NAT10通过Nox2-ROS- NF-κB通路调控巨噬细胞糖代谢重编程的机制研究》，广东省自然科学基金面上项目，15万

3. 2022年：《m⁶A甲基转移酶METTL3通过PGC1β介导的线粒体能量代谢促进破骨细胞分化的分子机制》，广东省自然科学基金面上项目，10万

4. 2017年：《DNA甲基化对LPS诱导牙髓细胞炎症反应的影响及调控机制》，国家自然科学基金面上项目，57万

【发表论文】

1. Zhan DJ, Wang F, Zeng DL, Hao LL, Ye Li, Qi YP* , Xu Q*. Development of a radiomic model to detect the retromolar canal on panoramic radiographs. Discov Med, 2025，37(193):383-393.

2. He JL#, Zhao YQ#, Zhang YW, Zhang ZQ, Li D*, Xu Q*. FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions. Cell Signal, 2024, 117:111098

3. Zhang WJ#, Bai YJ#, Hao LL#, Zhao YQ, Zhang LJ, Ding WQ, Qi YP, Xu Q*. One-carbon metabolism supports s-adenosylmethionine and m6A methylation to control the osteogenesis of BMSCs and bone formation. J Bone Miner Res, 2024，39(9): 1356-1370  

4. Bai YJ#, Zhang WJ#, Hao LL#, Zhao YQ, Tsai I-Chen, Qi YP,* Xu Q*. Acetyl-CoA-dependent ac4C acetylation promotes the osteogenic differentiation of LPS-stimulated BMSCs. Int Immunopharmacol, 2024,133:112124

5. Zhang LJ#, Tsai I-Chen# , Ni ZH, Chen BC, Zhang SY, Cai LH, Xu Q*. Copper chelation therapy attenuates periodontitis inflammation through cuproptosis/ autophagy/lysosome axis. Int J Mol Sci, 2024, 25(11):5890

6. Zhao YQ#, Ding WQ#, Cai YJ, Li QM, Zhang WJ, Bai YJ, Zhang YW, Xu Q*, Feng ZH*. The m6A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation. Biochim Biophys Acta Mol Basis Dis, 2024, 1870(7):167354

7. Zhang YW#, Kong YP#, Zhang WJ#, He JL, Zhang ZQ, Cai YJ, Zhao YQ，Xu Q*. METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis. Clin Epigenetics, 2024,16(1):18.

8. Zhang ZQ, Zhang YW, Cai YJ, Li D, He JL, Feng ZH*, Xu Q*. NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF-κB pathway in macrophages. Biochim Biophys Acta Mol Cell Res, 2023,1870(7):119521.

9. Cai YJ#, Yu RQ#, Zhang ZQ, Li D, Yi BC, Feng ZH,* Xu Q*. Mettl3/Ythdf2 regulate macrophage inflammation and ROS generation by controlling Pyk2 mRNA stability. Immunology Letters, 2023, 264 (2023): 64-73

10. Li D#, He JL#, Fang CH, Zhang YW, He ML, Zhang ZQ, Hou JS*, Xu Q*. METTL3 regulates osteoclast biological behaviors via iNOS/NO-Mediated mitochondrial dysfunction in inflammatory conditions. Int J Mol Sci, 2023, 24(2):1403.

11. He ML#, Li D#, Fang CH, Xu Q*. YTHDF1 regulates endoplasmic reticulum stress, NF-κB, MAPK and PI3K-AKT signaling pathways in inflammatory osteoclastogenesis. Arch Biochem Biophys, 2022, 732:109464

12. Cai LH, Li D, Feng ZH, Gu XF, Xu Q*, Li Q*. YTHDF2 regulates macrophage polarization through NF-κB and_MAPK signaling pathway inhibition or p53 degradation. Dis Markers, 2022:3153362

13. Yang Y, Lin Y, Xu R, Zhang Z, Zeng W, Xu Q*, Deng F*. Micro/Nanostructured Topography on Titanium Orchestrates Dendritic Cell Adhesion and Activation via β2 Integrin-FAK Signals. Int J Nanomedicine, 2022,1;17: 5117-5136.

14. Cai Y#, Yu R#, Kong Y, Feng Z, Xu Q*. METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway. Cell Signal, 2022;93:110283.

15. Kong Y#, Zhang Y#, Cai Y, Li D, Yi B, Xu Q*. METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation. Cell Signal, 2022; 95:110335.

16. Fang C#, He M#, Li D, Xu Q*. YTHDF2 mediates LPS-induced osteoclastogenesis and inflammatory response via the NF-κB and MAPK signaling pathways. Cell Signal, 2021, 85: 110060.

17. Feng Z#, Meng R #, Li Q, Li D, Xu Q*. 5-aza-2’-deoxycytidine may regulate the inflammatory response of human odontoblast-like cells through the NF-κB pathway. Int Endod J, 2021;54(7):1105-1117

18. Pang L, Li X, Wang K, Tao Y, Cui T, Xu Q*, Lin H *. Interactions with the aquaporin 5 gene increase the susceptibility to molar-incisor hypomineralization. Arch Oral Biol, 2020;111:104637.

19. Li Q#, Li J#, Feng Z, Lin H *, Xu Q*. Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells. Bioengineered,2020,11(1):449-462

20. Li D#, Cai L#, Meng R, Feng Z, Xu Q*. METTL3 modulates osteoclast differentiation and function by controlling RNA stability and nuclear export. Int J Mol Sci, 2020, 21(5): 1660.

21. Gu X#, Zhang Y#, Li D, Cai H, Cai L, Xu Q*. N6-methyladenosine demethylase FTO promotes M1 and M2 macrophage activation. Cell Signal, 2020, 69:109553.

22. Zhang Y#, Gu X#, Li D, Cai L, Xu Q*. METTL3 regulates osteoblast differentiation and inflammatory response via Smad signaling and MAPK signaling. Int J Mol Sci, 2020, 21(1): E119

23. Cai L#, Zhan M#, Li Q，Li D, Xu Q*. DNA methyltransferase DNMT1 inhibits lipopolysaccharideinduced inflammatory response in human dental pulp cells involving the methylation changes of IL6 and TRAF6. Mol Med Rep, 2020, 21(2): 959-968.

【参编教材与论著】

1. 2020年：参编《牙体牙髓病学病例精解》 科学技术文献出版社 

2. 2024年：参编《牙体牙髓病多学科诊疗病例精粹》 人民卫生出版社 9787117359917

【社会兼职】

1. 中华口腔医学会牙体牙髓病学专业委员会常委

2. 广东省口腔医学会牙体牙髓病学专业委员会常委

【联系方式】

地址：广州市陵园西路56号中山大学光华口腔医学院附属口腔医院

邮箱：xuqionggz@sina.cn   xqiong@mail.sysu.edu.cn