【学位 / 学历】

博士 / 博士研究生

【学术简历】

1981.09~1987.07  中山（医科）大学口腔医学专业获学士学位

1990.09~1992.07   中山（医科）大学口腔医学专业硕士学位

1994.09~1996.07   华西医科大学口腔医学专业获博士学位

1987.07-至今  中山大学附属口腔医院口腔医学 历任住院医师、讲师、副教授、主任医师、教授

【研究方向】

   口腔重大疾病基础与转化研究

【主持课题】

2022-2024年，202206080009：《口腔潜在恶性病变早期识别、风险预警及干预体系的研发与应用》，广州市科技计划项目，500万

【发表论文】

1. Zhang J, Peng J, Wang S, Wang L, Sun Y, Xia J, Cheng B, Hu Q. Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition. Cell Death Discov. 2025 Jan 28;11(1):30. doi: 10.1038/s41420-025-02314-1.

2．Sun Y, Wang C, Wen L, Ling Z, Xia J, Cheng B, Peng J. Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway. Int J Mol Med. 2025 Jan;55(1):4. doi: 10.3892/ijmm.2024.5445. Epub 2024 Oct 25.

3.Wu S, Yang S, Ou L, Zhang H, Wang L, Feng B, Bai Z, Li W, Cheng B, Toh WS, Xia J. Melatonin-Loaded Hydrogel Modulates Circadian Rhythms and Alleviates Oxidative Stress and Inflammation to Promote Wound Healing. ACS Appl Bio Mater. 2025 Jan 24. doi: 10.1021/acsabm.4c01752. Online ahead of print.

4.Zhou J, Hu Z, Wang L, Hu Q, Chen Z, Lin T, Zhou R, Cai Y, Wu Z, Zhang Z, Yang Y, Zhang C, Li G, Zeng L, Su K, Li H, Su Q, Zeng G, Cheng B, Wu T. Tumor-colonized Streptococcus mutans metabolically reprograms tumor microenvironment and promotes oral squamous cell carcinoma. Microbiome. 2024 Oct 5;12(1):193. doi: 10.1186/s40168-024-01907-9.

5.Li W, Zeng Q, Wang B, Lv C, He H, Yang X, Cheng B, Tao X. Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization. Redox Biol. 2024 Sep 5;76:103335. doi: 10.1016/j.redox.2024.103335. Online ahead of print.

6.Yang Z, Deng M, Ren L, Fan Z, Yang S, Liu S, Ren X, Gao J, Cheng B, Xia J. Pyroptosis of oral keratinocyte contributes to energy metabolic reprogramming of T cells in oral lichen planus via OPA1-mediated mitochondrial fusion. Cell Death Discov. 2024 Sep 17;10(1):408. doi: 10.1038/s41420-024-02174-1.

7.Cai G, Ren L, Yu J, Jiang S, Liu G, Wu S, Cheng B, Li W, Xia J. A Microenvironment-Responsive, Controlled Release Hydrogel Delivering Embelin to Promote Bone Repair of Periodontitis via Anti-Infection and Osteo-Immune Modulation. Adv Sci (Weinh). 2024，11(34):e2403786.， doi: 10.1002/advs.202403786. Online ahead of print.

8.Guo J, Su K, Wang L, Feng B, You X, Deng M, Toh WS, Wu J, Cheng B, Xia J. Poly(p-coumaric acid) nanoparticles alleviate temporomandibular joint osteoarthritis by inhibiting chondrocyte ferroptosis. Bioact Mater. 2024 Jun 12; 40:212-226. doi: 10.1016/j.bioactmat.2024.06.007. eCollection 2024 Oct.

9.Wang L, Yang R, Kong Y, Zhou J, Chen Y, Li R, Chen C, Tang X, Chen X, Xia J, Chen X, Cheng B, Ren X. Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC. Int J Oral Sci. 2024 Jun 17;16(1):44. doi: 10.1038/s41368-024-00310-2. ？？？

10.Shen Z, Zhang R, Huang Y, Chen J, Yu M, Li C, Zhang Y, Chen L, Huang X, Yang J, Lin Z, Wang S, Cheng B. The spatial transcriptomic landscape of human gingiva in health and periodontitis. Sci China Life Sci. 2024 Apr;67(4):720-732. doi: 10.1007/s11427-023-2467-1. Epub 2023 Dec 15.

11.Wang W, Zheng J, Hong X, Zhou J, Xiong Y, Yang H, Li S, Chen G, Su Q, Li W, Cheng B, Fu J, Wu T. Micro-environment triple-responsive hyaluronic acid hydrogel dressings to promote antibacterial activity, collagen deposition, and angiogenesis for diabetic wound healing. J Mater Chem B. 2024 May 15;12(19):4613-4628. doi: 10.1039/d4tb00261j.

12．Yang R, Zhang S, Wang L, Chen Y, Chen X, Xia J, Ren X, Cheng B, Chen X. Radiation-induced exosomes promote oral squamous cell carcinoma progression via enhancing SLC1A5-glutamine metabolism. J Oral Pathol Med. 2024，53(7):458-467. doi: 10.1111/jop.13561. Online ahead of print.

13.Wang L, Wang S, Zhang J, Peng J, Cheng B, Li H, Hu Q. Radiotherapy upregulated immune checkpoints contribute to the development of second primary OSCC. Oral Dis. 2024 May;30(4):2188-2201. doi: 10.1111/odi.14621. Epub 2023 May 22.

14.Shen Z, Kuang S, Zhang Y, Chen J, Wang S, Xu C, Huang Y, Zhang M, Huang S, Wang J, Zhao C, Lin Z, Shi X, Cheng B. Restoring periodontal tissue homoeostasis prevents cognitive decline by reducing the number of Serpina3nhigh astrocytes in the hippocampus. Innovation (Camb). 2023 Nov 24;5(1):100547. doi: 10.1016/j.xinn.2023.100547. eCollection 2024 Jan 8.

15.Li W, Wu S, Ren L, Feng B, Chen Z, Li Z, Cheng B, Xia J. Development of an Antiswelling Hydrogel System Incorporating M2-Exosomes and Photothermal Effect for Diabetic Wound Healing. ACS Nano. 2023 Nov 14;17(21):22106-22120. doi: 10.1021/acsnano.3c09220. Epub 2023 Oct 30.

16.Li Y, Ma Z, Li W, Xu X, Shen P, Zhang SE, Cheng B, Xia J. PDPN+ CAFs facilitate the motility of OSCC cells by inhibiting ferroptosis via transferring exosomal lncRNA FTX. Cell Death Dis. 2023 Nov 22;14(11):759. doi: 10.1038/s41419-023-06280-3.

17.Li W, Ling Z, Wang J, Su Z, Lu J, Yang X, Cheng B, Tao X. ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus. Biochem Pharmacol. 2023 Oct;216:115767. doi: 10.1016/j.bcp.2023.115767. Epub 2023 Aug 25.

18.Su Z, Lu J, Ling Z, Li W, Yang X, Cheng B, Tao X. Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus. Biochem Pharmacol. 2023 Oct;216:115796. doi: 10.1016/j.bcp.2023.115796. Epub 2023 Sep 9.

19.Li W, Xu X, Ma Z, Shen P, Cheng B, Xia J, Li Y. LncRNA BANCR promotes oral squamous cell carcinoma progression via regulating Rab1A signaling.  J Oral Pathol Med. 2023 Jul 11. doi: 10.1111/jop.13463. Online ahead of print.

20.Guan J, Xu X, Qiu G, He C, Lu X, Wang K, Liu X, Li Y, Ling Z, Tang X, Liang Y, Tao X, Cheng B, Yang B. Cellular hierarchy framework based on single-cell/multi-patient sample sequencing reveals metabolic biomarker PYGL as a therapeutic target for HNSCC. J Exp Clin Cancer Res. 2023 Jul 8;42(1):162. doi: 10.1186/s13046-023-02734-w

21.Peng J, Hu Q, Wang C, Zhang J, Wang S, Wang L, Xia J, Cheng B. Depletion of Gr1 + myeloid cells attenuates high-fat-diet-aggravated esophageal squamous cell carcinoma in mice. Carcinogenesis. 2023 Jun 23: bgad047. doi: 10.1093/carcin/bgad047. Online ahead of print.

22.Deng M, Guo J, Ling Z, Zhang C, He L, Fan Z, Cheng B, Xia J. KRAS mutations upregulate Runx1 to promote occurrence of head and neck squamous cell carcinoma. Mol Carcinog. 2023 May 24. doi: 10.1002/mc.23563. Online ahead of print.

23.Hu J, Ling Z, Li W, Su Z, Lu J, Zeng Q, Cheng B, Tao X. Glutamine promotes the proliferation of epithelial cells via mTOR/S6 pathway in oral lichen planus. J Oral Pathol Med. 2023 Feb;52(2):150-160. doi: 10.1111/jop.13391. Epub 2022 Dec 19.

24.Lu J, Su Z, Li W, Ling Z, Cheng B, Yang X, Tao X. ASCT2-mediated glutamine uptake of epithelial cells facilitates CCL5-induced T cell infiltration via ROS-STAT3 pathway in oral lichen planus. Int Immunopharmacol. 2023 Jun; 119:110216. doi: 10.1016/j.intimp.2023.110216. Epub 2023 Apr 26.

25.Chen W, Chen X, Wang L, Yang R, Zhang W, Zhang S, Xia J, Cheng B, Wu T, Ren X. TIPE3 represses head and neck squamous cell carcinoma progression via triggering PGAM5 mediated mitochondria dysfunction. Cell Death Dis. 2023 Apr 6;14(4):251. doi: 10.1038/s41419-023-05775-3.

26.Li J, Chen X, Ren L, Chen X, Wu T, Wang Y, Ren X, Cheng B, Xia J. Type H vessel/platelet-derived growth factor receptor β+ perivascular cell disintegration is involved in vascular injury and bone loss in radiation-induced bone damage. Cell Prolif. 2023 Jan 24:e13406. doi: 10.1111/cpr.13406. Online ahead of print.

27.He L, Guo J, Fan Z, Yang S, Zhang C, Cheng B, Xia J. Exosomal miR-146b-5p derived from cancer-associated fibroblasts promotes progression of oral squamous cell carcinoma by downregulating HIPK3. Cell Signal. 2023 Feb 20; 106:110635. doi: 10.1016/j.cellsig.2023.110635. Online ahead of print.

28.Pan X, Xu X, Wang L, Zhang S, Chen Y, Yang R, Chen X, Cheng B, Xia J, Ren X. BASP1 is a prognostic biomarker associated with immunotherapeutic response in head and neck squamous cell carcinoma. Front Oncol. 2023 Jan 27;13:1021262. doi: 10.3389/fonc.2023.1021262. eCollection 2023.

【参编教材与论著】

1. 2024年8月：主编《口腔科学》（第10版） 人民卫生出版社 978-7-117-36237-5

2. 2022年11月：副主编《口腔黏膜病学》（第2版） 人民卫生出版社 978-7-117-21679-1

3. 2022年3月：主编《口腔黏膜病学标准数据集》 科学出版社 978-7-030-71698-9

【获奖及学术荣誉】

1. 2024年 广东省五一劳动奖章

2. 2022 年 中国医院协会“优秀医院院长”

3. 2021年 广东“最美科技工作者”

4. 2020年 享受国务院政府特殊津贴专家

5. 2020年 全国宝钢优秀教师奖

6. 2020年 第四届全国“白求恩式好医生”

7. 2019年 第九届“广东省高等学校教学名师奖（本科）”

8. 2023年 国家一流本科线下一流课程负责人

9. 2023年 中山大学首届校级研究生教育教学成果奖一等奖(第一完成人)

10. 2023年 中山大学教育教学成果奖一等奖（第二完成人）

11. 2021年 第十届广东教育教学成果奖（高等教育类）一等奖（第一完成人）

12. 2020年 广东省科学技术奖二等奖（第二完成人）

【社会兼职】

1. 国务院学位委员会学科评议组成员

2. 教育部高等学校口腔医学专业教学指导委员会委员

3. 中华口腔医学会理事会常务理事

4. 中华口腔医学会口腔黏膜病专业委员会主任委员

5. 中华口腔医学会口腔生物医学专业委员会副主任委员

6. 广东省口腔医学会会长

【联系方式】

邮箱：chengbin@mail.sysu.edu.cn