【学位 / 学历】

博士 / 博士研究生

【学术简历】

1984.09~1990.06  中山医科大学口腔医学专业获学士学位

1998.09~2001.12  中山大学光华口腔医学院口腔医学专业获硕士学位

2009.09~2012.06  中山大学光华口腔医学院口腔临床医学专业获博士学位

【研究方向】

1.牙合发育

2.口颌疾病与中枢神经系统关系

【主持课题】

1. 2021.1~2023.12：《褪黑素靶向SIRT4调控线粒体功能促DPCs成牙本质向分化的分子机制研究》，广东省自然科学基金面上项目，10万元

2. 2024.01-2024.12.30：《声波牙刷在儿童咬合发育管理中的临床应用与评价-混合方法研究》，USMILE口腔健康研究基金产研合作类项目，10万元

3. 2019.1-2022.12.30：《基于ME2介导的褪黑素促进细胞有氧代谢调控DPCs成牙本质向分化的分子机制》，国家自然科学基金面上项目，57万元

4. 2024.01.01~2025.12.30：《基于 OMT 的 “咬合诱导” 儿童口腔医学本科教学多维融合模式的探索》， 广东省普通高等医学院校临床教学基地本科教学改革研究项目，1万元

5. 2021.1.1~2022.12.30：《OMT新理念引入儿童口腔医学线上线下教学一体化的探索.》，广东省高等教育教学研究和改革项目，1万元

【发表论文】

1.Xinyue Sheng, Jingzhou Li, Haozhen Ma, Hongwen He, Qin Liu, Shilin Jia, Fuping Zhang*, Fang Huang*. Piezo1 Regulates Odontogenesis via a FAM83G-Mediated Mechanism in Dental Papilla Cells In Vitro and In Vivo. Biomolecules. 2025.15(3), 316.

2.Jieyi Chen#, Wanting Chen#, Lude Lin, Haozhen Ma and Fang Huang*. The prevalence of dental caries and its associated factors among preschool children in Huizhou,China: a cross-sectional study. Front. Oral. Health. 2024 30;5:1461959.

3.Hanyi Chen, Lude Lin , Jieyi Chen* and Fang Huang *.Prevalence of Malocclusion Traits in Primary Dentition, 2010–2024:A Systematic Review. Healthcare. 2024  2;12(13):1321.

4.Jiayao Chen, Shuhong Kuang, Jietao Cen, Yong Zhang, Zongshan Shen, Wei Qin, Qiting Huang, Zifeng Wang, Xianling Gao, Fang Huang*, Zhengmei Lin*. Multiomics profiling reveals VDR as a central regulator of mesenchymal stem cell senescence with a known association with osteoporosis after high-fat diet exposure. International Journal of Oral Science. 2024 ;16(1):41.

5.X. Wang, Y. Zhou, C. Luo, J. Zhao, Y. Ji, Z. Wang, P. Zheng, D. Li, Y Shi, A. Nishiura, N. Matsumoto, Y. Honda*, B. Xu, F. Huang*.  Senolytics ameliorate the failure of bone regeneration through the cell senescence-related inflammatory signalling pathway. Biomedicine & Pharmacotherapy. 2024;175:116606.

6.Qi Huang# , Yumei Sun# , Wushuang Huang, Fuping Zhang , Hongwen He, Yifan He*, Fang Huang*. FTO Positively Regulates Odontoblastic Differentiation via SMOC2 in Human Stem Cells from the Apical Papilla under Inffammatory Microenvironment. Int J Mol Sci. 2024 ;25(7):4045.

7.Zhishan Zou, Wenguo Fan, Haotian Liu, Qing Liu, Hongwen He, Fang Huang*. The roles of 5-HT in orofacial pain. Oral Diseases. 2024;30(6):3838-3849.

8.Haotian Liu, Ke Xu, Yifan He*, Fang Huang *. Mitochondria in Multi-Directional Differentiation of Dental-Derived Mesenchymal Stem Cells. Biomolecules. 2023 ;14(1):12.

9.Ke Xu, Qin Liu, Wushuang Huang, Yanhao Chu, Wenguo Fan, Jiawei, Liu, Yifan He*, Fang Huang*. Promotive Effect of FBXO32 on the Odontoblastic Differentiation of Human Dental Pulp Stem Cells. Int J Mol Sci. 2023 ;24(9):7708.

10.Yanhao Chu, YaQi Wu, Silin Jia, Ke Xu, Jinyue Liu, Lijia Mai, Wenguo Fan*, Fang Huang*. Single-nucleus transcriptome analysis reveals transcriptional profiles of circadian clock and pain related genes in human and mouse trigeminal ganglion. Front Neurosci. 2023 ;17:1176654.

11.Haozhen Ma, Wanting Chen, Wenguo Fan, Hongwen He*, Fang Huang*. PER2 regulates odontoblastic differentiation of dental papilla cells in vitro by intracellular ATP content and ROS levels. PeerJ. 2023 Dec 7;11:e16489.

12.Yanhao Chu, Silin Jia, Ke Xu, Qing Liu, Lijia Mai, Jiawei Liu, Wenguo Fan*, Fang Huang*. Single-cell transcriptomic profile of satellite glial cells in trigeminal ganglion. Front Mol Neurosci. 2023 ;16:1117065.  

13.Chu Y, He H, Liu Q, Jia S, Fan W, Huang F*. The Circadian Clocks, Oscillations of Pain-Related Mediators, and Pain. Cell Mol Neurobiol. 2023;43(2):511-523.

14.Wushuang Huang , Qi Huang , Hongwen He * and Fang Huang*. PER2 Promotes Odontoblastic/Osteogenic Differentiation of Dental Pulp Stem Cells by Modulating Mitochondrial Metabolism. Int. J. Mol. Sci. 2023;24(13):10661.

15.Fuping Zhang, Shengyan Yang, Liulin Jiang, Jiawei Liu, Yifan He, Wenguo Fan, Fang Huang*, Hongwen He*. Melatonin-mediated malic enzyme 2 orchestrates mitochondrial fusion and respiratory functions to promote odontoblastic differentiation during tooth development. J Pineal Res. 2023;74(4):e12865.

16.Yulin Lan#, Jieyi Chen#, Shoucheng Chen, Jingxiang Lu, Xinle Yang, Yifan He*，Fang Huang*. Influences of adenoid hypertrophy on children's maxillofacial development. Healthcare. 2023 ;11(21):2812.

17.Lude Lin, Wanting Chen, Dejun Zhong, Xiayuan Cai, Jieyi Chen*, Fang Huang*. Prevalence and Associated Factors of Malocclusion among Preschool Children in Huizhou, China: A Cross-Sectional Study. Healthcare (Basel). 2023;11(7):1050.

18.Haoyun Sun, Miaomiao Zheng, Jiawei Liu, Wenguo Fan, Hongwen He*, Fang Huang*. Melatonin promoted osteogenesis of human periodontal ligament cells by regulating mitochondrial functions through the translocase of the outer mitochondrial membrane 20. Journal of Periodontal Research. 2023 ;58(1):53-69.

19.Haozhen Ma, Wanting Chen, Wenguo Fan, Hongwen He*, Fang Huang*. Roles of LonP1 in Oral-Maxillofacial Developmental Defects and Tumors: A Novel Insight. Int J Mol Sci. 2022 ;23(21):13370.

20.Yingying You, Xianping Yi, Hongwen He*, Fang Huang*. Effects of melatonin on orofacial pain relief by regulating mitochondrial function in cell viability of peripheral sensory neurons. Signa Vitae. 2022; 18(6): 81-93.

21.Lijia Mai, Shilin Jia, Qing Liu, Yanhao Chu, Jinyue Liu, Shengyan Yang, Fang Huang*, Wenguo Fan*. Sympathectomy Ameliorates CFA-Induced Mechanical Allodynia via Modulating Phenotype of Macrophages in Sensory Ganglion in Mice. J Inflamm Res. 2022 ;15:6263-6274.

22.Xu K, Chu Y, Liu Q, Fan W, He H, Huang F*. NEDD4 E3 Ligases: Functions and Mechanisms in Bone and Tooth. Int J Mol Sci. 2022;23(17):9937.

23.Liu Q, Mai LJ, Yang SY, Jia SL, Chu YH, He HW, Fan WG, and Huang F*. Transcriptional alterations of trigeminal ganglion neurons following orofacial inflammation revealed by single-cell analysis. Front Cell Neurosci. 2022 ;16: 885569.

24.Shengyan Yang, Qing Liu, Shijing Chen, Fuping Zhang, Yaoyin Li, Wenguo Fan, Lijia Mai, Hongwen He, Fang Huang*. Extracellular vesicles delivering nuclear factor I/C for hard tissue engineering: Treatment of apical periodontitis and dentin regeneration. Journal of Tissue Engineering. 2022 ;13:20417314221084095.

25.Jun Kang, Haoling Chen, Fuping Zhang, Tong Yan, Wenguo Fan, Liulin Jiang, Hongwen He * and Fang Huang*. RORα regulates odontoblastic differentiation and mediates the pro-odontogenic effect of melatonin on dental papilla cells. Molecules. 2021;26(4):1098.

26.Tong Yan#, Yongjian Xie#, Hongwen He, Wenguo Fan*, Fang Huang*. Role of nitric oxide in orthodontic tooth movement (Review). International Journal of Molecular Medicine. 2021;48(3):168.

27.Tong Yan, Yu Kong, Wenguo Fan, Jun Kang, Haoling Chen, Hongwen He *, Fang Huang*. Expression of nitric oxide synthases in rat odontoblasts and the role of nitric oxide in odontoblastic differentiation of rat dental papilla cells. Development, Growth & Differentiation. 2021 Sep;63(7):354-371.

28.Haozhen Ma, Jun Kang, Wenguo Fan, Hongwen He*, Fang Huang*. ROR: Nuclear Receptor for Melatonin or Not? Molecules. 2021;26(9):2693.

29.Haoling Chen, Jun Kang, Fuping Zhang, Tong Yan, Wenguo Fan, Hongwen He*, Fang Huang*. SIRT4 regulates rat dental papilla cell differentiation by promoting mitochondrial functions. International Journal of Biochemistry and Cell Biology. 2021;134:105962.

30.Haoling Chen, Wenguo Fan, Hongwen He*, Fang Huang*. PGC-1：a key regulator in bone homeostasis. PGC-1: a key regulator in bone homeostasis. J Bone Miner Metab. 2022 ;40(1):1-8.

31.Qing Liu, Hongwen He, Lijia Mai, ShengYan Yang, Wenguo Fan*, Fang Huang*. Peripherally Acting Opioids in Orofacial Pain. Front Neurosci. 2021 ;15:665445.

32.Qing Liu, Wenguo Fan, Hongwen He, Fang Huang*. The role of peripheral opioid receptors in orofacial pain. Oral Dis. 2021 ;27(5):1106-1114.

33.ShengYan Yang, Wenguo Fan, Yaoyi Li, Qing Liu, Hongwen He*, Fang Huang*. Autophagy in tooth: Physiology, disease and therapeutic implication. Cell Biochem Funct. 2021 ;39(6):702-712.

34.Huini Zhang, Qianyi Deng, Wenguo Fan, Miaomiao Zheng, Haoling Chen, Shijing Chen, Hongwen He*, Fang Huang*. Changes in Per1 and Per2 expression during early postnatal stage in rat masseters. Biological Rhythm Research. 2021.52(2), 246–260..

35.Shanshan Xie, Wenguo Fan, Hongwen He, Fang Huang*. Role of Melatonin in the Regulation of Pain. J Pain Res. 2020 ;13:331-343.  

36.ShanShan Xie, Wenguo Fan, Qing Liu, Jingzhou Li, Miaomiao Zheng, Hongwen He, Fang Huang*. Involvement of nNOS in the antinociceptive activity of melatonin in inflammatory pain at the level of sensory neurons. Eur Rev Med Pharmacol Sci. 2020 Jul;24(13):7399-7411.

37.Liulin Jiang#, Fang Huang*, Hongwen He*. Expression of circadian clock genes during differentiation of rat dental papilla cells in vitro. BIOL RHYTHM RES. 2020, 53(5), 753–764.

38.Miaomiao Zheng, Fang Huang*, Hongwen He*. Suppression of osteogenic differentiation and mitochondrial function change in human periodontal ligament stem cells by melatonin at physiological levels. PeerJ. 2020 ;8:e8663.

39.Jingzhou Li, Qianyi Deng, Wenguo Fan, Qi Zeng, Hongwen He*, Fang Huang*. Melatonin-induced suppression of DNA methylation promotes odontogenic differentiation in human dental pulp cells. Bioengineered. 2020 ;11(1):829-840.

40.何旭顺,陈诗菁,黄芳*.活动矫治器推磨牙远中进行乳磨牙早失间隙管理一例[J].中华口腔医学研究杂志(电子版),2021,15(06):360-367.

【参编教材与论著】

1. 2022年 参编《中国儿童错颌畸形早期矫治暨专家共识及病例解析》 四川大学出版社 978-7-5690-5757-7

2. 2020年 参编《实验口腔颌面解剖学》 中山大学出版社 978-7-306-06826-2

【获奖及学术荣誉】

1. 2023年 国家卫生健康委医院管理研究所儿童早期矫治规范化诊疗项目典型案例

2. 2023年 中山大学附属口腔医院医疗新技术奖三等奖

【社会兼职】

1. 中华口腔医学会儿童口腔医学专委会常务委员

2. 广东省口腔医学会儿童口腔医学专委会副主任委员

3. 广东省口腔医学会颞下颌关节病学及合学专业委员会常务委员

4. 广东省医学会口腔疾病防治专业委员会常务委员

【联系方式】

地址：广东省广州市天河区华夏路49号津滨腾越大厦南塔一楼口腔

邮箱：hfang@mail.sysu.edu.cn