余东升
教授 主任医师 博士生导师 硕士生导师
导师简介

学位 / 学历

博士 / 博士研究生

学术简历

1988.09-1993.06 武汉大学口腔医学专业获学士学位

1996.09-1999.06 武汉大学口腔医学专业获硕士学位

2001.09-2004.06 中山大学口腔医学专业获博士学位

研究方向

1.纳米材料介导的口腔鳞癌综合治疗

2.口腔鳞癌的放疗增敏治疗

3.口腔颌面部缺损修复和重建

4.口腔颌面部疼痛管理

主持课题

1. 2024-2027年:《细胞硬度介导口腔鳞癌细胞与CD8+T细胞间力学对话调控免疫杀伤的机制研究》,国家自然科学基金48

2. 2021-2024年:《磁性氧化石墨烯介导 CircATRNL1 促进铁死亡提高口腔鳞癌放射敏感性的实验研究》,国家自然科学基金55

3. 2019-2022年:《COL11A1 基因突变引起先天缺牙的分子机制及运用CRISPR/Cas9 技术进行基因修复的实验研究》,国家自然科学基金57万

4. 2024-2025年:《NSUN7介导的m5c修饰调控口腔鳞癌细胞硬度促进CD8+T细胞免疫杀伤的机制研究》,广东省自然科学基金15万

5. 2021-2023年:《CircATRNL1 介导铁过载促进铁死亡增强口腔鳞癌放疗敏感性的实验研究》,广东省自然科学基金10万

6. 2023-2024年:《电动牙刷牙龈安全性研究》,Usmile口腔健康研究基15万

发表论文

1.Li R, Lu Y, Du W, Wu J, He Y, Zhang L, Liu L, Li K, Zhuang W, Huang S, Wang Z, Zhao W, Zou X, Wang W, Yu D*. Modulating cell stiffness to improve macrophage antibacterial defense: Utilizing spermidine-functionalized black phosphorus nanosheets for periodontitis treatment. J MATER SCI TECHNOL. 2025 2025-01-01;235:91-109.

2.Zhuang W, Pan K, Wu J, Liu L, Lv S, Hu J, Shi F, Zhao W, Yu D*. Harnessing the power of traceable system C-GAP: homologous-targeting to fire up T-cell immune responses with low-dose irradiation. J Nanobiotechnology. 2025 Mar 12;23(1):207. 

3.He Y, Lu Y, Li R, Tang Y, Du W, Zhang L, Wu J, Li K, Zhuang W, Lv S, Han Y, Tao B, Deng F, Zhao W, Yu D*. CircAars-Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis. Adv Healthc Mater. 2025 Apr;14(10):e2404501. doi: 10.1002/adhm.202404501. Epub 2025 Mar 4. PMID: 40035523; PMCID: PMC12004435.

4.Lu H, Mu Q, Ku W, Zheng Y, Yi P, Lin L, Li P, Wang B, Wu J, Yu D*, Zhao W. Functional extracellular vesicles from SHEDs combined with gelatin methacryloyl promote the odontogenic differentiation of DPSCs for pulp regeneration. J Nanobiotechnology. 2024 May 17;22(1):265.

5.Wu J, Liu L, Du W, Lu Y, Li R, Wang C, Xu D, Ku W, Li S, Hou W, Yu D*, Zhao W. Modulating cell stiffness for improved vascularization: leveraging the MIL-53(fe) for improved interaction of titanium implant and endothelial cell. J Nanobiotechnology. 2024 Jul 17;22(1):422.

6.He Y, Tang Y, Zeng B, Chen X, Yuan L, Lu Y, Du W, Li R, Han Y, Deng F, Yu D*, Zhao W. Black phosphorus quantum dot-modified ADSCs as a novel therapeutic for periodontitis bone loss coupling of osteogenesis and osteoimmunomodulation. Mater Today Bio. 2024 Jun 10;27:101122.

7.He Y, Zhang L, Huang S, Tang Y, Li Y, Li H, Chen G, Chen X, Zhang X, Zhao W, Deng F, Yu D*. Magnetic Graphene Oxide Nanocomposites Boosts Craniomaxillofacial Bone Regeneration by Modulating circAars/miR-128-3p/SMAD5 Signaling Axis. Int J Nanomedicine. 2024 Apr 3;19:3143-3166.

8.Yi He, Fangyang Shi, Jiajun Hu, Hongyu Li, Xun Chen, Lingyu Yuan, Yunyang Lu, Weidong Du, Runze Li, Jie Wu, Feilong Deng, Dongsheng Yu*. Magnetic graphene oxide nanocomposites induce cytotoxicity in ADSCs via GPX4 regulating ferroptosis. Ecotoxicol Environ Saf. 2024;269:115745.

9.Yi P, Chen S, Zhao Y, Ku W, Lu H, Yu D*, Zhao W. An injectable dental pulp-derived decellularized matrix hydrogel promotes dentin repair through modulation of macrophage response. Biomater Adv. 2024 Jul;161:213883.

10.Liu Y, Li K, Zhuang W, Liang L, Chen X, Yu D*. Tetrahedral framework nucleic acid-based small-molecule inhibitor delivery for ecological prevention of biofilm. Cell Prolif. 2024 May 29:e13678.

11.Xiliu Zhang, Chen Yi, Lejia Zhang, Xinyu Zhu, Yi He, Huanzi Lu, Yiming Li, Yuquan Tang, Wei Zhao, Guosheng Chen, Cheng Wang, Siming Huang, Gangfeng Ouyang, Dongsheng Yu*. Size-optimized nuclear-targeting phototherapy enhances the type I interferon response for "cold" tumor immunotherapy. Acta Biomaterialia. 2023,Mar 159:338-352.

12.Leyi Liu, Jie Wu , Shiyu Lv , Duoling Xu, Shujun Li , Wentao Hou,Chao Wang,Dongsheng Yu*. Synergistic effect of hierarchical topographic structure on 3D-printed Titanium scaffold for enhanced coupling of osteogenesis and angiogenesis. Materials Today Bio. 2023, 23 (2023) 100866.

13..Jinxuan Zheng, Rongcheng Yu, Yiqi Tang, Sihui Su, Sainan Wang, Chenxi Liao, Xuecong Li, Jiabin Liao, Dongsheng Yu*, Tingting Ai, Wei Zhao, Vicky Yau, Chufeng Liu, Liping Wu, Yang Cao. Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium. Genes Dis. 2023;11(5):101194.

14.Jianfeng Liang, Hongshi Cai, Chen Hou, Fan Song, Yaoqi Jiang, Ziyi Wang, Danqi Qiu, Yue Zhu, Fang Wang, Dongsheng Yu*, Jinsong Hou. METTL14 inhibits malignant progression of oral squamous cell carcinoma by targeting the autophagy-related gene RB1CC1 in an m6A-IGF2BP2-dependent manner. Clinical Science. 2023, Sep 137(17):1373-1389.

15.Lejia Zhang , Kuangwu Pan , Siyuan Huang , Xiliu Zhang , Xinyu Zhu , Yi He , Xun Chen , Yuquan Tang , Lingyu Yuan , Dongsheng Yu*. Graphdiyne Oxide-Mediated Photodynamic Therapy Boosts Enhancive T-Cell Immune Responses by Increasing Cellular Stiffness. International Journal of Nanomedicine. 2023, Feb 15:18:797- 812.

16.Xun Chen, Lejia Zhang,Yi He,Siyuan Huang, Shangwu Chen, Wei Zhao, Dongsheng Yu*. Regulation of m6A modification on ferroptosis and its potential significance in radiosensitization. Cell Death Discovery. 2023, Sep 15;9(1):343.

17.Yi He , Fangyang Shi , Jiajun Hu , Hongyu Li , Xun Chen , Lingyu Yuan , Yunyang Lu , Weidong Du , Runze Li , Jie Wu , Feilong Deng , Dongsheng Yu*. Magnetic graphene oxide nanocomposites induce cytotoxicity in ADSCs via GPX4 regulating ferroptosis. Ecotoxicology and Environmental Safety.2023, Nov 28:269:115745.

18.Weijie Zhuang, Kechen Li, Yaxin Lu,Zifeng Liu, Dongsheng Yu*. Development and validation of machine learning based prediction model for postoperative pain risk after extraction of impacted mandibular third molars. Heliyon. 2023, Volume 9, Issue 12, e23052.

19.Xun Chen, Lingyu Yuan, Lejia Zhang, Liutao Chen,Yi He, Chao Wang, Jie Wu, Shangwu Chen, Wei Zhao&Dongsheng Yu*. GPX8 deficiency induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells. Epigenetics. 2023, Dec;18(1):2208707.

20.Lingyu Yuan, Xun Chen, Kuangwu Pan,Yi He, Hongyu Li, Dongsheng Yu*. Bioinformatic analysis and verification of a lipid metabolism-related long noncoding RNA prognostic signature for head and neck squamous cell carcinoma. Cellular Signaling. 2023, Dec112:110903.

21.Yexin Zheng, Hui Lu, Qing Mu, Ping Yi, Ling Lin, Pei Li, Dongsheng Yu* and Wei Zhao. Effects of sEV derived from SHED and DPSC on the proliferation, migration and osteogenesis of PDLSC. Regenerative Therapy. 2023, Sep 24: 489-498 .

22.Wang, C, Wu, J, Liu, L, Xu, D.; Liu, Y.; Li, S.; Hou, W.; Wang, J.; Chen, X.; Sheng, L.; Lin, H.; Yu, D*. Improving osteoinduction and osteogenesis of Ti6Al4V alloy porous scaffold by regulating the pore structure. Frontiers in Chemistry.2023,2296-2646,2023, May 17, 11, 1190630.

23.Yuhan Wu, Wenyi Zeng, Jiayun Xu, Yang Sun, Yucheng Huang, Dong Xiang, Chenguang Zhang, Zheng Fu, Feilong Deng, Dongsheng Yu*. Preparation, physicochemical characterization, and in vitro and in vivo osteogenic evaluation of a bioresorbable, moldable, hydroxyapatite/poly(caprolactone-co-lactide) bone substitute. J BIOMED MATER RES A.2023, Mar;111(3):367-377.

24.Li P, Zeng B, Xie W, Xiao X, Lin L, Yu D*, Zhao W. Enamel Structure Defects in Kdf1 Missense Mutation Knock-in Mice. Biomedicines. 2023, Feb 11(2):482.

25.Chen X, Chen L, Tang Y, He Y, Pan K, Yuan L, Xie W, Chen S, Zhao W, Yu D*. Transcriptome-wide mA methylome analysis uncovered the changes of mA modification in oral pre-malignant cells compared with normal oral epithelial cells. Front Oncol. 2022 Sep 28;12:939449.

26.Chen X, Kuang S, He Y, Li H, Yi C, Chen G, Chen S, Yu D*. Differential metabolic response of oral squamous cell carcinoma cells and normal oral epithelial cells to cisplatin exposure. J Metabolites. 2022 Apr 25;12(5):389.

27.Zhou L, Li H, Cai H, Liu W, Pan E, Yu D*, He S. Upregulation of IGF2BP2 Promotes Oral Squamous Cell Carcinoma Progression That Is Related to Cell Proliferation, Metastasis and Tumor-Infiltrating Immune Cells. J Front Oncol. 2022 Mar 1; 12:809589.

28.Xu D, Wang C, Wu J, Fu Y, Li S, Hou W, Lin L, Li P, Yu D*, Zhao W. Effects of Low-Concentration Graphene Oxide Quantum Dots on Improving the Proliferation and Differentiation Ability of Bone Marrow Mesenchymal Stem Cells through the Wnt/β-Catenin Signaling Pathway. J ACS Omega. 2022 Apr 18;7(16):13546-13556.

29.Xie W, Zeng B, Li P, Xu D, Yu D*, Zhao W. Two Novel Mutations in Ectodysplasin-A Identified in Syndromic Tooth Agenesis. J Coll Physicians Surg Pak. 2022 May;32(5):570-574.

30.Xun Chen, Liutao Chen, Yuquan Tang, Yi He, Kuangwu Pan, Linyu Yuan, Weihong Xie, Shangwu Chen, Wei Zhao, Dongsheng Yu*. Transcriptome-wide m6A methylome analysis uncovered the changes of m6A modification in oral pre-malignant cells compared with normal oral epithelial cells. J Front Oncol. 2022 Sep 28; 12:939449.

31.Yuhan Wu, Wenyi Zeng, Jiayun Xu, Yang Sun, Yucheng Huang, Dong Xiang, Chenguang Zhang, Zheng Fu, Feilong Deng, Dongsheng Yu*. Preparation, physicochemical characterization, and in vitro and in vivo osteogenic evaluation of a bioresorbable, moldable, hydroxyapatite/poly(caprolactone-co-lactide) bone substitute. J Biomed Mater Res A. 2022 Oct 21.

32.Yi C, Zhang X, Li H, Chen G, Zeng B, Li Y, Wang C, He Y, Chen X, Huang Z, Yu D*. EPHB4 Regulates the Proliferation   and Metastasis of Oral Squamous Cell Carcinoma through the HMGB1/NF-κB Signalling Pathway. J Cancer.2021 Aug 20;12(20):5999-6011.

33.He Y, Chen G, Li Y, Li Y & Yu D*. Effect of magnetic graphene oxide on cellular behaviors and osteogenesis under a moderate static magnetic field. J Nanomedicine. 2021 Oct; 37:102435.

34.Li HY, Zhang XL, Yi C, He Y, Chen X, Zhao W, Yu DS*. Ferroptosis-related gene signature predicts the prognosis in Oral squamous cell carcinoma patients. J BMC CANCER.2021-07.

35.He Y, Yi C, Zhang X, Zhao W, & Yu D*. Magnetic graphene oxide: synthesis approaches, physicochemical characteristics, and biomedical applications. TrAC Trends in Analytical Chemistry, 2021-04-19,136, 116191.

36.Chen X, Yi C, Yang MJ, Sun X, & Yu D*. Metabolomics study reveals the potential evidence of metabolic  reprogramming towards the warburg effect in precancerous lesions. Journal of Cancer, 2021, 12(5), 1563-1574.

37.Gao S, Lu JX, Li, P (Li, Pei), Yu DS*, Zhao W. Prevalence and risk factors of children's dental anxiety in China: a longitudinal study [J]. BMJ Open, 2021, 11(4).

38.Li, YM, Chen, GH, He, Y, Yi, C, Zhang, XL, Zeng, BH, Huang, ZQ, Deng, FL, Yu,DS* .Selenomethionine-Modified Polyethylenimine-Based Nanoparticles Loaded with miR-132-3p Inhibitor-Biofunctionalized Titanium Implants for Improved Osteointegration [J]. Acs Biomaterials Science & Engineering, 2021, 7(10): 4933-45.

39.Li, YM, He Y, Chen GH, Huang ZQ, Yi C, Zhang XL, Deng FL, Yu, DS*. Selenomethionine protects oxidative-stress- damaged bone-marrow-derived mesenchymal stem cells via an antioxidant effect and the PTEN/PI3K/AKT pathway [J]. Experimental Cell Research, 2021, 408(2).

40.Yang X; Zhao Q; Chen JW ; Liu JY; Lin, JC; Lu, JX; Li, WQ; Yu, DS*; Zhao, W.Graphene Oxide Quantum Dots Promote Osteogenic Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth via the Wnt/beta-Catenin Signaling Pathway [J]. Stem Cells International, 2021.

41.Wang, C; Xu, DL; Lin, L ; Li, SJ ; Hou, WT ; He, Y; Sheng, LY; Yi, C; Zhang, XL ; Li, HY ; Li, YM ; Zhao, W ; Yu, DS*. Large-pore-size Ti6Al4V scaffolds with different pore structures for vascularized bone regeneration. [J]. Materials Science & Engineering C-Materials for Biological Applications, 2021, 131

42.Zhang, WL; Zeng, BH ; Lin, HC; Guan, W ; Mo, J; Wu, S; Wei, YJ; Zhang, QS ; Yu, DS*; Li, WZ; Chan, GCF. CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects [J]. Oncoimmunology, 2021, 10(1).

43.Wang C, Xu D, Li S, Yi C, & Yu D*. Effect of pore size on the physicochemical properties and osteogenesis of ti6al4v porous scaffolds with bionic structure.[J]ACS Omega, 2020 Oct 26;5(44):28684-28692.

44.Zhang X, Li H, Yi C, Chen G, & Yu D*. Host immune response triggered by graphene quantum-dot-mediated photodynamic therapy for oral squamous cell carcinoma. Int J Nanomedicine. 2020 Dec 1; 15:9627-9638.

45.Chen X, Chen S, Yu D*. Protein kinase function of pyruvate kinase M2 and cancer[J]. Cancer Cell International, 2020, 20(1);1475-2867.

46.Chen X, Chen S, Yu D*. Metabolic Reprogramming of Chemoresistant Cancer Cells and the Potential Significance of Metabolic Regulation in the Reversal of Cancer Chemoresistance[J]. Metabolites, 10(7).2020-07/1563-1574.

47.Chen G, Li Y, He Y, Zeng B, Yi C, Wang C, Zhang X, Zhao W, Yu D*. 2020. Upregulation of Circular  RNA circATRNL1 to Sensitize Oral Squamous Cell Carcinoma to Irradiation[J] Mol Ther Nucleic Acids, 2020, 19: 961-973.

48.Kang X, Li Y, Wang Y, Zhang Y, Yu D*, Peng Y. Relationships of Stresses on Alveolar Bone and Abutment of Dental Implant from Various Bite Forces by Three-Dimensional Finite Element Analysis. Biomed Res Int. 2020 Feb 19;2020:7539628.

49.He Y, Li Y, Chen G, Wei C, Zhang X, Zeng B, Yi C, Wang C, Yu D*. Concentration‐dependent cellular behavior and osteogenic differentiation effect induced in bone marrow mesenchymal stem cells treated with magnetic graphene oxide. J BIOMED MATER RES A. 2020-01-01;108(1):50-60.

50.Chen Jingwen, Zhao Qi, Peng Jianmin, Yang Xin, Yu Dongsheng *, Zhao Wei . Antibacterial and mechanical properties of reduced graphene-silver nanoparticle nanocomposite modified glass ionomer cements. doi: 10.1016/j.jdent.2020.103332.

51.中华口腔医学会口腔急诊专业委员会. 恒牙外伤牙固定术技术专家共识[J]. 中华口腔医学杂志,2022,57(04):326-333。

52.中华口腔医学会口腔急诊专业委员会. 口腔诊疗过程中伴发急性全身性病症的规范化椅旁急救专家共识[J]. 中华口腔医学杂志,2022,57(05):441-454。DOI:10.3760/cma.j.cn112144-20220119-00024。

53.高慧,余东升*.国际牙外伤学会牙外伤预防指南(2024版)解读[J].口腔医学, 2024,44(12):881-886.DOI:10.13591/j.cnki.kqyx.2024.12.001。

54.张茜柳,余东升*. 医源性牙外伤的发生原因和防治策略[J/OL]. 中华口腔医学研究杂志(电子版),2024,18(5)。

55.何毅,韩曜岭,余东升*. 环状RNA的功能及其在牙周炎中的研究进展 [J/OL]. 口腔疾病防治, 1-11[2024-08-07]。

56.何毅,余东升*. 铁死亡在牙周炎中的研究进展 [J/OL]. 口腔疾病防治, 1-9[2024-08-07]。

57.陆云洋,杜维东,余东升*。M5C甲基化修饰及其在肿瘤免疫治疗中的研究进展。口腔疾病防治,2024,2月第32卷第2期。

58.何毅,余东升*. 年轻恒牙脱位性损伤的诊疗进展[J/OL]. 中华口腔医学研究杂志(电子版),2023,17(6)。

59.刘杨;朱亚琴;余东升;雷容;黄萍;李强;陈永进.中国口腔急诊建设现状的调查分析[J].中国实用口腔科杂志,2022,15(05):539-545。

60.张茜柳,朱新宇,张玏珈,余东升*.光动力介导的免疫调控作用及其在口腔医学领域中的作用特点[J].中国实用口腔科杂志,2022,15(05):620-624。

61.李泓钰,刘燕婷,余东升*.铁死亡与肿瘤放射治疗的研究进展.中华口腔医学研究杂志(电子版). 2021,15(06)。

62.向媛媛,张伟娜,黄宇蕾,王琳,杨菁,王润夫,余东升,章小缓.口腔颌面外科住院患者医院感染病原学特征及相关因素分析.中华口腔医学研究杂志(电子版). 2021,15(03)。

63.易晨,黄子贤,余东升*.Hippo信号通路在口腔鳞状细胞癌中的研究进展.中华口腔医学研究杂志(电子版).2020,14(06)。

64.谢伟鸿,余东升,赵玮.非综合征型先天缺牙致病基因和分子机制的研究进展.口腔疾病防治. 2020,28(04)。

65.曾藩韬,余东升*.敲低circ0001273抑制口腔鳞癌细胞增殖、迁移及侵袭的研究.口腔疾病防治. 2020,28(03)。

参编教材与论著

1. 2009年 参编《颌骨肿瘤诊断与治疗》 上海科技出版社 9787532394265

2. 2011年 参编《口腔颌面外科学精选模拟习题集》 中国旅游出版社 9787117135856

3. 2024年 参编《口腔急诊医学》 人民卫生出版社 9787117368933

社会兼职

1. 中华口腔医学会口腔急诊专业委员会主委

2. 广东省口腔急诊专业委员会主委

3. 中华口腔医学会牙及牙槽外科专业委员会常务委员

4. 中华口腔医学会口腔病理专业委员会委员

5. 广东省口腔医学会老年口腔专业委员会副主任委员

6. 广东省口腔医学会医院感染控制与管理专业委员会副主任委员

7. 中国抗癌协会广东省头颈外科专业委员委员

8. 中华医学会广东省医院感染管理专业委员会委员委员

9. 《中华口腔医学研究杂志(电子版)》编委

10.  《Journal of dentistry》Editorial Board

11. 国家自然科学基金评审专家

12. 北京市自然科学基金评审专家

13. 广东省自然科学基金评审专家

14. 广东省千师万苗工程科技导师

联系方式

地址广州市陵园路56号(邮编 510055)

传真:020-83862543

邮箱:yudsh@mail.sysu.edu.cn