王成 | 中山大学附属口腔医院

王成

主任医师博士生导师硕士生导师

导师简介

【学位 / 学历】

博士 / 研究生

【学术简历】

2000.09-2005.06 兰州大学口腔医学专业获学士学位

2005.09-2008.06 中山大学口腔临床医学专业获硕士学位

2008.09-2011.06 中山大学口腔临床医学专业获博士学位

【研究方向】

口腔-颌面头颈肿瘤分子发病机制及精准诊疗

【主持课题】

1. 2025-2028年：《COL11A1+肿瘤相关肌成纤维细胞促进头颈鳞癌Tumor budding细胞免疫逃逸的机制研究》，国家自然科学基金面上项目，49万

2. 2022-2024年：《基于单细胞测序和空间转录组学解析成釉细胞瘤复发的关键调控机制》，国家自然科学基金专项项目，60万

3. 2021-2024年：《超级增强子驱动“CYTOR-FOSL1正反馈环路”促进口腔鳞癌Tumor budding转移的研究》，国家自然科学基金面上项目，55万

4. 2024-2026年：《CD276-ANXA1双特异性抗体药物的研发与应用》，广州市科技计划项目重点研发计划，50万

5. 2022-2025年：《早期口腔癌隐匿性转移及免疫逃逸机制研究》，国家万人计划青年拔尖人才，190万

【发表论文】

1.Wang C, Li Y, Jia L, Kim JK, Li J, Deng P, Zhang W, Krebsbach PH, Wang CY*. CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance. Cell Stem Cell. 2021 Sep 2;28(9):1597-1613.e7.

2.Wang W#, Yun B#, Hoyle RG#, Ma Z, Zaman SU, Xiong G, Yi C, Xie N, Zhang M, Liu X, Bandyopadhyay D, Li J, Wang C. CYTOR Facilitates Formation of FOSL1 Phase Separation and Super Enhancers to Drive Metastasis of Tumor Budding Cells in Head and Neck Squamous Cell Carcinoma. Adv Sci (Weinh). 2024 Jan;11(4):e2305002.

3.Xiong G#, Xie N#, Nie M, Ling R, Yun B, Xie J, Ren L, Huang Y, Wang W, Yi C, Zhang M, Xu X, Zhang C, Zou B, Zhang L, Liu X, Huang H, Chen D, Cao W, Wang C*. Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma. Int J Oral Sci. 2024 Feb 29;16(1):21.

4.Xu X#, Xie J#, Ling R, Ouyang S, Xiong G, Lu Y, Yun B, Zhang M, Wang W, Liu X, Chen D, Wang C. Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma. Int J Oral Sci. 2023 Sep 7;15(1):38. Int J Oral Sci. 2023 Sep 7;15(1):38.

5.Zhang M#, Wang G#, Ma Z, Xiong G, Wang W, Huang Z, Wan Y, Xu X, Hoyle RG, Yi C, Hou J, Liu X, Chen D, Li J, Wang C. BET Inhibition Triggers Anti-tumor Immunity by Enhancing MHC Class I Expression in Head and Neck Squamous Cell Carcinoma. Mol Ther. 2022 Nov 2;30(11):3394-3413.

6.Zhang M#, Hoyle RG#, Ma Z, Sun B, Cai W, Cai H, Xie N, Zhang Y, Hou J, Liu X, Chen D, Kellogg GE, Harada H, Sun Y, Wang C, Li J. FOSL1 Promotes Metastasis of Head and Neck Squamous Cell Carcinoma Through Super-Enhancer-Driven Transcription Program. Mol Ther. 2021 Aug 4;29(8):2583-2600.

7.Zhuang Z#, Yu P#, Xie N#, Wu Y, Liu H, Zhang M, Tao Y, Wang W, Yin H, Zou B, Hou J, Liu X, Li J, Huang H, Wang C*. MicroRNA-204-5p is a tumor suppressor and potential therapeutic target in head and neck squamous cell carcinoma. Theranostics 2020; 10(3):1433-1453.

8.Ouyang S, Zhang J, Ren L, Huang Y, Zhang W, Pan C, Zhuang Z, Wang C. Risk Factors and Nomogram for Predicting the Recurrence of Conventional Ameloblastoma. Oral Dis. 2025 Apr 28. doi: 10.1111/odi.15360.

9.Xie J, Zhang J, Xiong G, Ouyang S, Yun B, Xu X, Wang W, Zhang M, Xie N, Chen D, Wang C. Targeting BRD4 attenuates the stemness and aggressiveness of ameloblastoma. Oral Dis. 2024 Jul;30(5):3212-3224.

10.Wang W, Yun B, Xiang Z, Liu X, Yi C, Ouyang S, Zhang X, Xiong G, Zhuang Z, Wang C. A multi-omics analysis reveals KDELR1 promotes malignant progression and correlates with tumor microenvironment in head and neck squamous cell carcinoma. Cell Signal. 2025 Mar:127:111613.

11.Cai H, Liang J, Jiang Y, Wang Z, Li H, Wang W, Wang C, Hou J. KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma. J Exp Clin Cancer Res. 2024 Mar 5;43(1):69.

12.Lu Y, Xiang Z, Wang W, Yun B, Yi C, Zhang M, Xie N, Wang C, Zhuang Z. Establishment and validation of a tumor-infiltrating γδT cell related prognostic gene signature in head and neck squamous cell carcinoma. Int Immunopharmacol. 2024 May 10;132:112054.

13.Zhao Z, Xiong G, Wang C, Cao W. From pathogenesis to precision medicine: Transformative advances in research and treatment of ameloblastoma. Cancer Lett. 2025 Mar 1;612:217448.

14.Huang Z#, Lu Y#, Wang W, Xie N, Yi C, Xiong G, Xu X, Zhang M, Wang C*. Prognostic value of tumor-infiltrating immune cells in clinical early-stage oral squamous cell carcinoma. J Oral Pathol Med. 2023 May;52(5):372-380. doi: 10.1111/jop.13357.

15.Feng K, Hu J, Huang Q, Cai W, Zhuang Z, Liu H, Hou J, Liu X, Wang C*. Risk factors and Nomogram for Predicting Carotid Blowout Syndrome Based on Computed Tomography Angiography. Oral Diseases. 2022 Nov;28(8):2131-2138.

16.Wang W#, Xie N#, Yi C, Zhang M, Xiong G, Xu X, Hou J, Wang C*. Prognostic and clinicopathological significance of cytocapsular tubes in oral squamous cell carcinoma. J Oral Pathol Med. 2022 Jul;51(6):520-528.

17.Xu X#, Gan X#, Zhang M, Xie J, Chen S, Li K, Li J, Bao Y, Wang C, Chen D. Sox9 + cells are required for salivary gland regeneration after radiation damage via the Wnt/β-catenin pathway. J Genet Genomics. 2022 Mar;49(3):230-239.

18.Wang F#, Liao Y#, Zhang M#, Zhu Y, Wang W, Cai H, Liang J, Song F, Hou C, Huang S, Zhang Y, Wang C, Hou J. N6-methyladenosine demethyltransferase FTO-mediated autophagy in malignant development of oral squamous cell carcinoma. Oncogene. 2021 Jun;40(22):3885-3898.

19.Wang X#, Li K#, Wan Y#, Chen F, Cheng M, Xiong G, Wang G, Chen S, Chen Z, Chen J, Xu X, Wang C, Peng L, Chen D*. Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma. Int J Oral Sci. 2021 Aug 11;13(1):26. doi: 10.1038/s41368-021-00130-8.

【参编教材与论著】

1. 2018年参编《穿支皮瓣：口腔颌面与头颈部的应用》上海交通大学出版社 978-7-313-17392-8/R

2. 2020年参编《放射性颌骨坏死临床诊断与治疗》上海科学技术出版社 978-7-5478-4594-3/R-1928

3. 2023、2024年副主编全国卫生专业技术资格考试习题集丛书《口腔颌面外科学同步习题集》人民卫生出版社 978-7-117-34082-3

【获奖及学术荣誉】

1. 2022年国家万人计划青年拔尖人才

2. 2024年广州好医生

3. 2024年羊城好医生

【社会兼职】

1. 中国抗癌协会口腔颌面肿瘤整合医学专业委员会青年委员会副主任委员

2. 中华口腔医学会口腔颌面外科专业委员会委员

3. 中华口腔医学会口腔颌面头颈肿瘤专业委员会委员

4. 中华口腔医学会口腔生物医学专业委员会委员委员

5. 中国中西医结合学会口腔医学专业委员会常委

6. 中国抗癌协会青年理事会理事

7. 中国抗癌协会口腔癌整合防筛专业委员会常委常委

8. 广东省医学会颌面-头颈外科学分会副主任委员

9. 广东省精准医学应用学会口腔肿瘤分会副主任委员

10. 广东省口腔医学会口腔颌面外科专业委员会常委

11. 广东省抗癌协会肿瘤整形专业委员会常委

【联系方式】

地址：广州市陵园西路56号

邮箱：wangch75@mail.sysu.edu.cn

【研究方向】

口腔-颌面头颈肿瘤分子发病机制及精准诊疗

【主持课题】

【发表论文】

1.Wang C, Li Y, Jia L, Kim JK, Li J, Deng P, Zhang W, Krebsbach PH, Wang CY*. CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance. Cell Stem Cell. 2021 Sep 2;28(9):1597-1613.e7.

4.Xu X#, Xie J#, Ling R, Ouyang S, Xiong G, Lu Y, Yun B, Zhang M, Wang W, Liu X, Chen D*, Wang C*. Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma. Int J Oral Sci. 2023 Sep 7;15(1):38. Int J Oral Sci. 2023 Sep 7;15(1):38.

5.Zhang M#, Wang G#, Ma Z, Xiong G, Wang W, Huang Z, Wan Y, Xu X, Hoyle RG, Yi C, Hou J, Liu X, Chen D, Li J*, Wang C*. BET Inhibition Triggers Anti-tumor Immunity by Enhancing MHC Class I Expression in Head and Neck Squamous Cell Carcinoma. Mol Ther. 2022 Nov 2;30(11):3394-3413.

6.Zhang M#, Hoyle RG#, Ma Z, Sun B, Cai W, Cai H, Xie N, Zhang Y, Hou J, Liu X, Chen D, Kellogg GE, Harada H, Sun Y, Wang C*, Li J*. FOSL1 Promotes Metastasis of Head and Neck Squamous Cell Carcinoma Through Super-Enhancer-Driven Transcription Program. Mol Ther. 2021 Aug 4;29(8):2583-2600.

7.Zhuang Z#, Yu P#, Xie N#, Wu Y, Liu H, Zhang M, Tao Y, Wang W, Yin H, Zou B, Hou J, Liu X, Li J*, Huang H*, Wang C*. MicroRNA-204-5p is a tumor suppressor and potential therapeutic target in head and neck squamous cell carcinoma. Theranostics 2020; 10(3):1433-1453.

8.Ouyang S, Zhang J, Ren L, Huang Y, Zhang W, Pan C, Zhuang Z*, Wang C*. Risk Factors and Nomogram for Predicting the Recurrence of Conventional Ameloblastoma. Oral Dis. 2025 Apr 28. doi: 10.1111/odi.15360.

9.Xie J, Zhang J, Xiong G, Ouyang S, Yun B, Xu X, Wang W, Zhang M, Xie N, Chen D*, Wang C*. Targeting BRD4 attenuates the stemness and aggressiveness of ameloblastoma. Oral Dis. 2024 Jul;30(5):3212-3224.