【学位 / 学历】

博士 / 研究生

【学术简历】

2005.09-2010.06 中山大学光华口腔医院口腔医学（七年制）专业获学士学位

2010.07-2012.07 中山大学光华口腔医院口腔医学（七年制）专业获硕士学位

2012.09-2015.12 澳大利亚昆士兰科技大学生物医学工程专业获博士学位

【研究方向】

1.口腔种植周软硬组织再生修复研究

2.口腔智能决策大模型的构建与实践

【主持课题】

1. 2025年：《上颌窦CBCT 影像病理性异常人工智能决策支持系统的横断面诊断试验》，广东省口腔疾病临床医学研究中心“临床研究专项”，30万

2. 2024-2026年：《口腔种植体周围炎免疫稳态失衡机制及其应用研究》，广州市科技计划项目，基础与应用基础研究专题（科技菁英“领航”方向）项目，30

3. 2023-2025年：《基于“血凝块-免疫复合体调控”的口腔骨再生材料研发及应用研究》，广东省科技计划项目，国际科技合作领域项目，50万

4. 2023-2026年：《口腔种植临床类脑智能决策平台构建及应用推广》，广州市科技计划项目，农业和社会发展科技专题重点研发计划项目，100万

5. 2022-2027年：《“基于再生原理的牙颌生物重建及其转化应用研究”课题二“牙颌再生中炎症微环境与干细胞间交互调控研究”项目》，国家重点研发计划“ 干细胞研究与器官修复” 重点专项项目，616万元

6. 2021-2024年：《基于调控巨噬细胞HIF的仿缺氧水凝胶体系构建及其成骨/破骨稳态调节机制和凹坑型牙槽骨缺损修复应用》，国家自然科学基金面上项目，55万

7. 2025 年：《新医科背景下口腔种植研究生临床教育基地的教学数智化探索与实践》，中山大学研究生教育创新计划项目，1万

8. 2024年：《口腔基础研究导论》，广东省研究生教育创新计划项目，5万

9. 2023-2024年：《口腔种植手术虚拟仿真教学实验课程建设》，中山大学本科教学质量工程类项目，20万

10. 2022-2023年：《口腔基础研究导论线上线下混合式一流课程》，中山大学本科教学质量工程类项目，3万

11. 2020-2021年：《以创新人才培养模式为导向的口腔基础研究课程建设与实践》，广东省高校青年教师高等教育学研究课题

12. 2021-2023年：《Tuning immune response to manipulate the multi-faceted effects of gingival fibroblasts for improving gingival- and osseo-integration》，ITI Research Grant，Small Grant 2020 (1536_2020)，49488.60美金

【发表论文】

教学论文：

1.Qianmin Ou#, Deqian Tan#, Shijie Chen#, Zhuohong Gong, Manqing Liu, Xuejing Gan, Gengbin Cai, Xiaolan Li, Xuebin B. Yang, Yun Hong*, Zetao Chen*. The landscape and challenges of postgraduate dental basic research education: a scoping review. BMC Oral Health, 2025 accepted. (IF: 2.6)

2.Xuejing Gan#, Qianmin Ou#, Zhuohong Gong#, Gengbin Cai, Xinyu Liu, Ruihan Yang, Yuhang Lin, Lin Li, Xiaolan Li, Yun Hong*, Zetao Chen*. A “flexible”compulsory dental basic research course for undergraduatestudents:a three-year retrospective study. BMC Oral Health, 2024, 24:1133. (IF: 2.6)

3.Zhuohong Gong#, Xuejing Gan#, Haiwen Liu, Mengru Shi, Shijie Chen, Junlong Xue, Gengbin Cai, Shangyou Wen, Jiayu Li, Shuheng Huang, Yun Hong, Lin Li*, Zetao Chen*. The Development and Training Effect of Innovative Undergraduate Dental Talents Training Project: A Six-Year Retrospective Study. European Journal of Dental Education, 2024;28:621–630. (IF: 1.7)

4.Haiwen Liu#, Zhuohong Gong#, Chen Ye, Xuejing Gan, Shijie Chen, Lin Li, Yun Hong, Junqing Xu, Zhengmei Lin*, Zetao Chen*. The Picture of Undergraduate Dental Basic Research Education: A Scoping Review. BMC Medical Education, 2022, 22569, 1-21. (IF: 2.7)

临床论文：

1.Peisheng Zeng#, Rihui Song#, Shijie Chen#, Xiaohang Li, Haopeng Li, Yue Chen, Zhuohong Gong, Gengbin Cai, Yixiong Lin, Mengru Shi*, Kai Huang*, Zetao Chen*. Expert-guided StyleGAN2 image generation elevates AI diagnostic accuracy for maxillary sinus lesions. Communication Medicine, 2025 accepted. (IF: 5.4)

2.Gengbin Cai#, Beichen Wen#, Zhuohong Gong#, Yixiong Lin, Hengyi Liu, Peisheng Zeng, Mengru Shi*, Ruixuan Wang*, Zetao Chen*. Intelligent virtual dental implant placement via 3D segmentation strategy. Journal of Dental Research, 2025 accepted. (IF: 5.7)

3.Zhuohong Gong#, Gengbin Cai#, Jiayang Zeng#, Beichen Wen, Hengyi Liu, Jiahong Lin, Xiaofei Meng, Peisheng Zeng, Jiamin Shi, Rui Xie, Yang Yu, Yin Xiao, Mengru Shi*, Ruixuan Wang*, Zetao Chen*. Expertise-inspiredal framework for clinically applicable reconstruction of tooth-centric radiaplanes: development and multicenter validation. BMEMat, 2025 accepted. (IF: N/A)

4.Mengru Shi#, Shijie Chen#, Haiwen Liu#, Gengbin Cai, Zhuohong Gong, Jiamin Shi, Guangqi Gao, Zhuofan Chen, Quan Liu*, Zetao Chen*. Quantitative analysis of the basal bone width as an index for immediate implant placement in the esthetic zone: A retrospective study. Journal of Prosthodontic Research, 2025, 10.2186/jpr.JPR_D_23_00299 (IF: 3.2)

5.Xiaomeng Gao#, Xinyu Guo#, Yong Ao#, Mengru Shi, Xuejing Gan, Baoxin Huang, Zetao Chen*. A digital in situ bone augmentation workflow for reconstructing the alveolar ridgeoutline using a modified shell technique. Journal of Prosthetic Dentistry, 2024,S0022-3913(24)00517-1. (IF: 4.3)

6.Mengru Shi#, Zhuohong Gong#, Peisheng Zeng#, Dawei Xiang, Gengbin Cai, Hengyi Liu, Shijie Chen, Runheng Liu, Zhuofan Chen*, Xinchun Zhang*, Zetao Chen*.  Multi-quantifying maxillofacial traits via a demographic parity-based AI model. BME Frontiers, 2024, 13: 5: 0054. (IF: 5.0)

7.Zhuohong Gong#, Guangqi Gao#, Mengru Shi#, Xuejing Gan, Gengbin Cai, Hongcheng Chen, Cuijun Li, Zhuofan Chen*, Danying Chen*, and Zetao Chen*. Integrated correlation analysis of the thickness of the buccal bone and gingiva of the maxillary incisors. Journal of Applied Oral Science, 2024;32:e20240018. (IF: 2.2)    

8.Haiwen Liu#, Jiaxu Duan#, Peisheng Zeng#, Mengru Shi, Jiayang Zeng, Shijie Chen, Zhuohong Gong, Zhuofan Chen*, Jiaxiang Qin*, Zetao Chen*. Intelligently quantifying the entire irregular dental structure. Journal of Dental Research, 2024;103(4):378-387. (IF: 5.7)

9.Runheng Liu#, Ruidi Xia#, Linjun Zhang#, Xuejing Gan, Cuijun Li, Quan Liu, Zhuofan Chen*, Zetao Chen*. The influence of guide stabilizers and their application sequences on trueness and precision of surgical guides in free end situations: An in vitro analysis. Clinical Oral Implants Research, 2024, 35(3): 294-304. (IF: 4.8)

10.Zhuwei Huang#, Jiamin Shi#, Guangqi Gao, Mengru Shi, Zhuohong Gong, Haiwen Liu, Peisheng Zeng, Shijie Chen, Xuejing Gan, Jianfeng Ding, Yan Wang*, Zetao Chen*. Quantification of the apical palatal bone index for maxillary incisor immediate implant assessment: a retrospective cross-sectional study. Journal of Stomatology oral and Maxillofacial Surgery, 124(2023), 101634. (IF: 1.8)

11.Zhuohong Gong#, Xiaohui Li#, Mengru Shi#, Gengbin Cai, Shijie Chen, Zejun Ye, Xuejing Gan, Ruihan Yang, Ruixuan Wang* and Zetao Chen*. Measuring the binary thickness of buccal bone of anterior maxilla in low-resolution CBCT via a bilinear convolutional neural network. Quantitative Imaging in Medicine and Surgery, 2023, 13(12): 8053–8066. (IF: 2.9)

12.Peisheng Zeng#, Rihui Song#，Yixiong Lin#, Haopeng Li，Shijie Chen，Mengru Shi，Gengbin Cai，Zhuohong Gong，Kai Huang*，Zetao Chen*. Abnormal maxillary sinus diagnosing on CBCT images via object detection and “straight-forward” classification deep learning strategy. Journal of Oral Rehabilitation, 2023, 50(12): 1465-1480. (IF: 3.1)

13.Yixiong Lin#, Mengru Shi#, Dawei Xiang#, Peisheng Zeng, Zhuohong Gong, Haiwen Liu, Quan Liu, Zhuofan Chen, Juan Xia*, Zetao Chen*. Construction of an end-to-end regression neural network for the determination of a quantitative index sagittal root inclination. Journal of Periodontology, 2022, 93:1951-1960. (IF: 4.2)

14.Mengru Shi#, Haiwen Liu#, Xiaoshuang Wang, Zhuohong Gong, Peisheng Zeng, Baoxin Huang* and Zetao Chen*. A decision tree with updated views of timing of implant placement for single maxillary anterior residual root. Journal of Dentistry and Oral Biology, 2022, 7(1):1185.

15.Mengru Shi#, Xiaoshuang Wang#, Peisheng Zeng#, Haiwen Liu, Zhuohong Gong, Yixiong Lin, Zhipeng Li*, Zetao Chen*, Zhuofan Chen. Analysis of the sagittal root angle and its correlation with hard and soft tissue indices in anterior teeth for immediate implant evaluation - A retrospective study. BMC Oral Health, 2021, 21：494. (IF: 2.6)

科研论文：

1.Guanqi Liu#, Junlong Xue#, Xuan Zhou#, Mixiao Gui, Ruidi Xia, Yanshu Zhang, Yihua Cai, Shuhua Li, Songtao Shi, Xueli Mao*, Zetao Chen*. The paradigm shifts of periodontal regeneration strategy: from reparative manipulation to developmental engineering. Bioactive Materials, 2025, 49, 418-436. (IF: 18.0)

2.Zongpu Han#, Jieyun Xu#, Xinyu Guo#, Lingyu Liang, Linjun Zhang, Yu Su, Wendong Gao, Qingming Tang, Lili Chen, Zhuofan Chen*, Yin Xiao*, Zetao Chen*. The biomaterial and blood clot complex: a crucial early environment for osteo-coagulo-immunomodulation and the advancement of bone biomaterials. Small structures, 2025, 2400625.  (IF 13.9)

3.Xuan Zhou#, Junlong Xue#, Yanshu Zhang#, Ruidi Xia, Zhengjie Shan, Linjun Zhang, Mixiao Gui, Guanqi Liu*, Zetao Chen*. Evolution of BHA modification strategy: the anti-inflammation approach rescues the Calcium-NLR-inflammation axis mediated periodontal redevelopment failure. Biomaterials Research, 2025, 29, 0131.  (IF: 8.1)

4.Lv Xie#, Zhengjie Shan#, Linjun Zhang#, Xinyi He#, Mixiao Gui, Yingye Zhang, Junlong Xue, Chen Ye, Yang Zou, Mengxi Su, Zhuofan Chen, Shiyu Wu*, Yin Xiao*, Zetao Chen*. Metal Ion “Adjuvant” [Si-O4] Tetrahedron Addresses Coagulation Interruption and Promotes Multi-Tissue Regeneration via Smart Ionic Capturing and Cell Membrane Transporting. Advanced Functional Materials, 2025, 35, 2416743. (IF: 18.5)

5.Yixiong Lin#, Yang Zou#, Jieting Yang#, Zongpu Han#, Xinyu Guo, Xiaomeng Gao, Jieyun Xu, Zhuohong Gong, Ruizhi Li, Zhipeng Li, Baoxin Huang, Yin Xiao*, Feilong Deng*, Zetao Chen*. Systemic T-cell and local macrophage interactions mediate granule size-dependent biological hydroxyapatite foreign body reaction. BMEMat, 2025, e12133. (IF: N/A)

6.Yong Ao#, Ruidi Xia#, Yuanlong Guo#, Yihua Cai, Xinyu Guo, Jingyi Wang, Zetao Chen*. Mechanoimmunomodulation-based strategy on advancing tissue-engineered nanotopographic structures. Microstructure, 2025, 5, 2025015. (IF: N/A)  

7.Jieyun Xu#, Xiaoran Yu#, Hongcheng Chen#, Junlong Xue#, Zhuohong Gong, Zhengjie Shan, Shijie Chen, Yuanlong Guo, Xiaomeng Gao, Linjun Zhang, Yin Xiao*, Feilong Deng*, Zetao Chen*. Nature knows best: Extracellular matrix-gelatin hydrogel-masking bioauthentic bone scaffold locking blood clot to induce M2 macrophage-mediated bone regeneration via activating an endocytosis-macroautophagy-inflammation axis. Small structures, 2024, 2400499.  (IF 13.9)

8.Guanqi Liu#, Ruidi Xia#, Mixiao Gui#, Linjun Zhang, Xuan Zhou, Junlong Xue, Yihua Cai, Yang Cao*, Yin Xiao*, Zetao Chen*. Turn hood into good: recycling silicon from MSNs carrier by Mg modification to reduce toxicity and conducive to tissue regeneration. ACS Nano, 2024, 18(47), 32932–32949.  (IF 15.8)

9.Zongpu Han#, Yixiong Lin#, Xinyu Guo#, Jieyun Xu, Xiaomeng Gao, Ruihan Yang, Zhao Yuan, Mixiao Gui, Linjun Zhang, Yuanlong Guo, Zetao Chen*. “Osteo-organogenesis Niche” Hyaluronic Acid Engineered Materials Directing Re-osteo-organogenesis Via Manipulating Macrophage CD44-MAPK/ERK-ETV1/5-MRC1 Axis. Advanced Healthcare Materials, 2024, 2403122. (IF: 10.0)

10.Yong Ao#, Yuanlong Guo#, Yingye Zhang#, Lv Xie, Ruidi Xia, Jieyun Xu, Mengru Shi, Xiaomeng Gao, Xiaoran Yu, Zetao Chen*. Hypoxia-mimicking mediated macrophage elimination of erythrocytes promotes bone regeneration via regulating Integrinαvβ3 /Fe2+-Glycolysis-Inflammation. Advanced Science, 2024, 11(45), 2403921. (IF: 14.3)

11.Shoucheng Chen#, Guangqi Gao#, Jiamin Shi#, Na Li#, Lv Xie, Yingye Zhang, Zhengjie Shan, Jiaxin Xie, Yin Xiao*, Zhuofan Chen*, Zetao Chen*. Unveiling the Governing Role of ‘Remodeling Triangle Area’ in Soft and Hard Tissue Equilibrium for Metal Implants Advancement. Materials Today Bio, 2024, 28: 101170 . (IF: 8.7)

12.Xiaomeng Gao#, Jieting Yang#, Xuejing Gan#, Yixiong Lin, Jieyun Xu, Zhengjie Shan, Zongpu Han, Shijie Chen, Baoxin Huang*, Bingfeng Fan*, Zetao Chen*. Optimized DLP 3D-printed high-resolution nano zirconia-hydroxyapatite scaffold with cranial soft tissue invasion resistance and pro-osteogenic properties via dectin-1/syk inflammatory axis. Chemical Engineering Journal, 2024, 491, 152044. (IF: 13.4)

13.Xingchen Liu#, Shudan Deng#, Xiyan Li#, Haiwen Liu, Zhixin Li, You Wu, Pu Luo, Xinyi Zhong, Ruoxuan Huang, Runheng Liu, Xiayi Wu, Baoxin Huang, Zetao Chen*, Zhuofan Chen*, Shoucheng Chen*. A standardized rat model to study transmucosal osseointegrated implants peri implantitis. Biomaterials Research, 2024, 28, 0021. (IF: 8.1)

14.Lingyu Liang, Zongpu Han, Ruihan Yang, Yuanlong Guo*, Zetao Chen*. Research hotspots and trends of nanomaterials in stomatology: A bibliometric analysis from 2000-2023. Heliyon, 2024, 10(6): e27967. (IF: 3.4)

15.Guanqi Liu#, Linjun Zhang#, Xuan Zhou#, Junlong Xue#, Ruidi Xia, Xuejing Gan, Chunxiao Lv, Yanshu Zhang, Xueli Mao, Xiaoxing Kou, Songtao Shi, Zetao Chen*. Inducing the “re-development state” of periodontal ligament cells via tuning macrophage mediated immune microenvironment. Journal of Advanced Research, 2024, 60, 233-248. (IF: 11.4)

16.Yang Zou#, Zhengjie Shan#, Zongpu Han#, Jieting Yang Yixiong Lin, Zhuohong Gong, Lv Xie, Jieyun Xu, Runlong Xie, Zhuofan Chen, Zetao Chen*. Regulating blood clot fibrin films to manipulate biomaterials-mediated foreign body responses. Research, 2023, 6, 0225. (IF: 8.5)

17.Shoucheng Chen#, Jiamin Shi#, Guangqi Gao#, Lv Xie, Yingye Zhang, Zhengjie Shan, Zhuwei Huang, Xinchun Zhang*, Zhuofan Chen*, Zetao Chen*. Immunomodulation-based development engineering for advancing metal soft tissue implants. Smart Materials in Medicine, 2023, 4, 562-577 (IF: N/A)

18.Yuanlong Guo#, Yong Ao#, Chen Ye#, Ruidi Xia#, Jiaomei Mi, Zhengjie Shan, Mengru Shi, Lv Xie, Zetao Chen*. Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β2 to manipulate inflammatory responses. Nano Research, 2023, 16 (7), 9715-9729 (IF: 9.5)

19.Peina Huang#, Jieyun Xu#, Lv Xie#, Guangqi Gao, Shoucheng Chen, Zhuohong Gong, Xiaomei Lao, Zhengjie Shan, Jiamin Shi, Zhaocai Zhou, Zhuofan Chen, Yang Cao*, Yan Wang*, Zetao Chen*. Improving hard metal implant and soft tissue integration by modulating the ‘inflammatory-fibrous complex’ response. Bioactive Materials, 2023, 20, 42-52 (IF: 18.0)

20.Shoucheng Chen#, Zhuwei Huang#, Rahul Madathiparambil Visalakshan, Haiwen Liu, Akash Bachhuka, You Wu; Ruvini Dabare, Pu Luo; Runheng Liu, Zhuohong Gong, Yin Xiao, Krasimir Vasilev*, Zhuofan Chen*; Zetao Chen*. Plasma polymerized bio-interface directs fibronectin adsorption and functionalization to enhance "epithelial barrier structure" formation via FN-ITG β1-FAK-mTOR signaling cascade. Biomaterials Research, 2022, 26(88), 1-21. (IF: 8.1)

21.Zhengjie Shan#, Lv Xie#, Haiwen Liu#, Jiamin Shi, Peisheng Zeng, Mixiao Gui, Xianzhi Wei, Zhuwei Huang, Guangqi Gao, Shijie Chen, Shoucheng Chen, Zetao Chen*. “Gingival Soft Tissue Integrative” Lithium Disilicate Glass-Ceramics with High Mechanical Properties and Sustained-Release Lithium Ions". ACS Applied Materials & Interfaces, 2022, 14 (49), 54572-54586. (IF:8.3)

22.Guanqi Liu#, Xuan Zhou#, Linjun Zhang#, Yang Zou, Junlong Xue, Ruidi Xia, Nuerbiya Abuduxiku，Xuejing Gan, Runheng Liu，Zhuofan Chen*, Yang Cao*, Zetao Chen*. Cell-free immunomodulatory biomaterials mediated in situ periodontal multi-tissue regeneration and their immunopathophysiological processes. Materials Today Bio, 2022, 16, 100432 (IF: 8.7)

23.Shiyu Wu#, Zhengjie Shan#, Lv Xie#, Mengxi Su, Peisheng Zeng, Peina Huang, Lingchan Zeng, Xinyue Sheng, Zhipeng Li, Gucheng Zeng*, Zhuofan Chen*, Zetao Chen*. Mesopore controls the responses of blood clot-immune complex via modulating fibrin network. Advanced Science, 2022, 9(3), 2103608 (IF: 14.3)

24.Yuanlong Guo#, Jiaomei Mi#, Chen Ye#, Yong Ao, Mengru Shi, Zhengjie Shan, Bingzhi Li, Zetao Chen*, Zhuofan Chen, Krasimir Vasilev, Yin Xiao. A practical guide to promote informatics-driven efficient biotopographic material development. Bioactive Materials, 2022, 8, 515-528 (IF: 18.0)

25.Runheng Liu#, Shoucheng Chen#, Peina Huang, Guanqi Liu, Pu Luo, Zhipeng Li, Yin Xiao, Zhuofan Chen*, Zetao Chen*. Immunomodulation-based strategy for improving soft tissue and metal implant integration and its implications in the development of metal soft tissue materials. Advanced Functional Materials, 2020, 30(21), 1910672. (IF: 18.5)

26.Guanqi Liu#, Xiaoshuang Wang#, Xuan Zhou#, Linjun Zhang, Jiaomei Mi, Zhengjie Shan, Baoxin Huang*, Zhuofan Chen*, Zetao Chen* Modulating the cobalt dose range to manipulate multisystem cooperation in bone environment: a strategy to resolve the controversies about cobalt use for orthopedic applications. Theranostics, 2020, 10(3), 1074-1089. (IF:12.4)

【参编教材与论著】

1. 2024年 《单颗后牙种植修复决策路径及操作实践》 人民卫生出版社978-7-117-36825-4

2. 2020年 《口腔基础研究导论》 人民卫生出版社 978-7-117-36825-4

3. 2020年 《口腔种植学词典》 人民卫生出版社 978-7-117-30565-

【获奖及学术荣誉】

1. 2024年 广东省高等教育学会第三届高等教育研究优秀成果奖一等奖

2. 2024年 羊城好医生

3. 2024年 广州好医生

4. 2023年 中山大学首届校级研究生教育教学成果奖一等奖

5. 2022年 广东省教育教学成果奖，一等奖

6. 2021年 广东省学位与研究生教育学会优秀教育成果奖

7. 2020年 国家自然科学基金申报立项优秀贡献奖

【社会兼职】

1. 中华口腔医学会口腔生物医学专委会常务委员

2. 中华口腔医学会口腔医学设备器材分会第五届委员会常务委员

3. 中国生物材料学会青年委员会委员

4. 中华口腔医学会口腔医学科研管理分会委员

5. 广东省口腔医学会口腔种植专委会常务委员

【联系方式】

地址：广东省广州市越秀区陵园西路56号

邮箱：chenzet3@mail.sysu.edu.cn