陈泽涛
研究员 博士生导师
导师简介

[学位/学历]

2005-2010  中山大学光华口腔医学院 本科

2010-2012  中山大学光华口腔医学院 七年制硕士 (口腔种植学)

2012-2015  澳大利亚昆士兰科技大学 博士

 

[学术简历]

就职于中山大学光华口腔医学院٠附属口腔医院,任研究员、主治医师(口腔种植科),博士生导师。现任中山大学科学研究院基地处副处长,广东省牙颌系统修复重建技术与材料工程技术研究中心副主任。入选国家海外高层次人才计划、广东省杰出青年科学基金项目、广东省珠江人才计划青年拔尖人才项目。

2012年毕业于中山大学光华口腔医学院,获口腔临床医学(种植学)硕士学位。2015年毕业于澳大利亚昆士兰科技大学,取得博士学位。从事口腔种植相关医教研工作,聚焦软硬组织再生修复的免疫机制及其调控研究,成果发表于Advanced Functional Materials,ACS Nano,Materials Today等。共发表SCI学术论文37篇,累计影响因子达268.079,通讯10篇,第一/并列第一16篇,一作/通讯发表大于10分的SCI学术论文7篇。参编外语专著1部(The Immune Response to Implanted Materials and Devices)。申请专利2项,参与获批专利1项。主持包括ITI Research Grant, The Osteology Foundation Research Grant在内的国际项目4项,国家自然科学基金在内的项目5项。

    教学方面,参与口腔种植学的教学工作,并致力于推动口腔基础研究的教学改革与实践。主编《口腔基础研究导论》(人民卫生出版社,2020,ISBN: 978-7-117-29325-9)。从2016年起,作为学院“科创育才”协会指导教师与学生科联合连续举办四届“口腔科研训练营”,探索以第二课堂形式培养学生创新基础研究能力,并初步建立口腔创新基础研究能力的教学评价体系;2020年作为课程负责人与教学科联合创建“口腔基础研究导论”课程,将创新基础研究能力的培养融入第一课堂。从口腔基础研究课程的建立与实践、教材的编写、到教学评价体系的构建,这一系列的教学改革工作获得了2项省级及3项校级教学类项目支持。

[研究方向]

1.    口腔软硬组织再生修复过程的免疫调控机制

2.    口腔生物材料的免疫调控性能

3. 免疫智能口腔生物材料的研发及其在口腔软硬组织再生修复中的应用

 

[主持课题]

教学类项目:

1.    2020-2022年,中山大学本科教学质量工程类项目

2.    2020-2021年,广东省高校青年教师高等教育学研究课题

3.    2019-2019年,中山大学研究生教育创新计划项目

4.    2019-2020年,广东省高等教育教学研究和改革项目(综合类项目,第二参与人)

5.    2018-2019年,中山大学本科教学质量工程类项目

 

科研类项目:

1.    2018-2020年,国家自然科学基金青年基金

2.    2018-2021年,广东省杰出青年科学基金项目

3.    2017-2022年,广东省珠江人才计划青年拔尖人才项目

4.    2017-2019年,中山大学青年教师培育项目

5.    2016-2018年,中山大学百人计划启动基金

 

国际项目:

1.    2019-2020年,The  Osteology Foundation, Young Researcher Grant (18-016)

2.    2018-2020年,ITI Research Grant,Small Grant 2017 (1267_2017)

3.    2016-2017年,The Osteology Foundation, Young  Researcher Grant (15-004)

4.    2015-2016年,The Prince Charles Hospital Foundation,New Investigator Gran t (NI2015-102)

 

[发表论文(近三年)]

基础研究:

1.      Runheng  Liu#, Shoucheng Chen#, Peina Huang, Guanqi Liu, Pu Luo,  Zhipeng Li, Yin Xiao, Zhuofan Chen*, Zetao  Chen*. Immunomodulation-based strategy for improving soft tissue and  metal implant integration and its implications in the development of metal  soft tissue materials.. Advanced Functional Materials, 2020, accepted. (IF:  15.621)

2.      Guanqi  Liu#, Xiaoshuang Wang#, Xuan Zhou#, Linjun  Zhang, Jiaomei Mi, Zhengjie Shan, Baoxin Huang*, Zhuofan Chen*, Zetao Chen*. Modulating the  cobalt dose range to manipulate multisystem cooperation in bone environment:  a strategy to resolve the controversies about cobalt use for orthopedic  applications. Theranostics, 2020, 10(3), 1074-1089. (IF: 8.063)

3.      Lingling  Chen#, Guanqi Liu#, Jinyan Wu, Xuan Zhou, Yiming Zhao, Zetao Chen*, Zhengmei Lin*,  Yin Xiao. Multi-faceted effects of mesenchymal stem cells (MSCs) determined  by immune microenvironment and their implications on MSC/biomaterial-based  inflammatory disease therapy. Applied Materials Today, 2020, 18, 100458. (IF:  8.013)

4.      Zetao Chen#,  Rahul Madathiparambil Visalakshan#, Jia Guo#, Fei Wei,  Linjun Zhang, Lingling Chen, Zhengmei Lin*, Krasimir Vasilev*, Yin Xiao*.  Plasma deposited poly-oxazoline nanotextured surfaces dictate  osteoimmunomodulation towards ameliorative osteogenesis. Acta Biomaterialia,  2019, 15: 568-581 (IF: 6.638)

5.      Guanqi  Liu#, Yuanlong Guo#, Linjun Zhang#,  Xiaoshuang Wang, Runheng Liu, Peina Huang, Yin Xiao, Zhuofan Chen*, Zetao Chen*. A standardized  rat burr hole defect model to study maxillofacial bone regeneration. Acta Biomaterialia,  2019, 86:456-60 (IF: 6.638)

6.      Shiyu  Wu#, Binbin Xia#, Sui Mai#, Zhicai Feng,  Xiaoshuang Wang, Yudong Liu, Runheng Liu, Zhipeng Li, Yin Xiao*, Zhuofan  Chen*, Zetao Chen*. Sodium  fluoride under dose range of 2.4-24 μM, a promising osteoimmunomodulatory  agent for vascularized bone formation. ACS Biomaterials Science &  Engineering, 2019, 5 (2): 817–830. (IF 4.511)

7.      Wei  Qiao#, Runheng Liu#, Zhipeng Li, Xin Luo, Baoxin Huang,  Quan Liu, Zetao Chen, James  Kit Hon Tsoi, Richard Yu Xiong Su, Kenneth M.C. Cheung, Jukka Matinlinna*,  Kelvin Yeung*, Zhuofan Chen*. Contribution of the in situ release of  endogenous cations from xenograft bone driven by fluoride incorporation  toward enhanced bone regeneration. Biomaterials Science, 2018, 6: 2951-64 (IF  5.251)

8.      Fei  Wei#, Guanqi Liu#, Yuanlong Guo, Ross Crawford, Zetao Chen*, Yin Xiao*. Blood  prefabricated hydroxyapatite/tricalcium phosphate induces ectopic  vascularized bone formation via modulating the osteoimmune environment.  Biomaterials Science, 2018, 6(8):2156-71 (IF 5.251)

9.      Runheng  Liu#, Yixiong Lin#, Jinying Lin#, Linjun  Zhang, Xueli Mao, Baoxin Huang, Yin Xiao, Zhuofan Chen*, Zetao Chen*. Blood prefabrication subcutaneous small  animal model for the evaluation of bone substitute materials. ACS  Biomaterials Science & Engineering, 2018, 4(7):2516-2527 (IF  4.511)

10.  Zetao Chen#,  Lingling Chen#, Runheng Liu#, Yixiong Lin, Shoucheng  Chen, Shifeier Lu, Zhengmei Lin, Zhuofan Chen*, Chengtie Wu*, Yin Xiao*. The osteoimmunomodulatory  property of barrier collagen membrane and its manipulation via coating  nanometer-sized bioactive glass to improve guided bone regeneration.  Biomaterials Science, 2018, 6(5):1007-19 (IF 5.251)

11.  Runheng  Liu#, Wei Qiao#, Baoxin Huang, Zetao Chen, Jinghan Fang, Zhipeng Li*, Zhuofan Chen*,  Fluorination enhances osteogenic capacity of porcine hydroxyapatite, Tissue  Engineering Part A, 2018, 24(15-16):1207-17 (IF 3.616)

12.  Shoucheng  Chen#, Yuanlong Guo#, Runheng Liu#, Shiyu  Wu, Jinghan Fang, Baoxin Huang,  Zhipeng Li, Zhuofan Chen*, Zetao  Chen*. Tuning surface properties of bone biomaterials to manipulate  osteoblastic cell adhesion and the signaling pathways for the enhancement of  early osseointegration. Colloids and Surfaces B: Biointerfaces, 2018, 164:  58-69. (IF: 3.973)

13.  Zetao Chen#,  Shengwei Han#, Mengchao Shi, Guanqi Liu, Zhuofan Chen, Jiang  Chang, Chengtie Wu*, Yin Xiao*. Immunomodulatory effects of mesoporous silica  nanoparticles on osteogenesis: from nanoimmunotoxicity to nanoimmunotherapy.  Applied Materials Today, 2018, 10: 184-93. (IF: 8.013)

14.  Zetao Chen#, Akash  Bachhuka#, Fei Wei, Xiaoshuang Wang, Guanqi Liu, Krasimir Vasilev*,  Yin Xiao*. Nanotopography-based strategy on the precise manipulation of  osteoimmunomodulation in bone regeneration. Nanoscale, 2017, 9: 18129-52. (IF:  6.970)

15.  Mengchao  Shi#, Lunguo Xia#, Zetao  Chen, Fang Lv, Huiying Zhu, Fei Wei, Shengwei Han, Jiang Chang, Yin  Xiao*, Chengtie Wu*. Europium-doped mesoporous silica nanosphere as an immune-modulating  osteogenesis/angiogenesis agent. Biomaterials, 2017, 144: 176-87. (IF:  10.273)

16.  Xufang  Zhang#, Qingpiao Chen#, Jianwei Liu, Qi Wei, Zetao Chen, Xueli Mao*.  Parthenolide promotes differentiation of osteoblasts through Wnt/β-catenin  signaling pathway in inflammatory environment. Journal of Interferon and  Cytokine Research, 2017, 37(9): 406-414. (IF:1.774)

17.  Zetao Chen#,  Akash Bachhuka#, Shengwei Han, Fei Wei, Shifeier Lu, Rahul  Visalakshan, Krasimir Vasilev*, Yin Xiao*. Tuning chemistry and topography of  nanoengineered surfaces to manipulate immune response for bone regeneration  applications. ACS Nano, 2017, 11(5): 4494-506. (IF 13.903)

18.  Gaojie  Yang#, Haoming Liu#, Xixi Hu, Zetao Chen, Thor Friis, Jianglin Wang, Yin Xiao*, Shengmin  Zhang*. Bio-inspired hybrid nanoparticles promote vascularized bone  regeneration in a morphology-dependent manner. Nanoscale, 2017, 9: 5794-805.  (IF  6.970)

19.  Shengwei  Han, Zetao Chen*, Pingping  Han, Qingang Hu, Yin Xiao*. Activation of macrophages by lipopolysaccharide  for assessing the immunomodulatory property of biomaterials. Tissue  Engineering Part A, 2017, 23 (19-20): 1100-9. (IF 3.616)

20.  Zetao Chen#,  Siyu Ni#, Shengwei Han, Ross Crawford, Shifeier Lu, Fei Wei, Jiang  Chang, Chengtie Wu*, Yin Xiao*. Nanoporous microstructures mediate  osteogenesis by modulating the osteo-immune response of macrophages.  Nanoscale. 2017, 9: 706-18. (IF 6.970)

临床研究:

21.  Yudong  Liu#,Qifan Liu#, Zhipeng Li, Aneesha  Acharya, Danying Chen, Zetao Chen,  Nikos Mattheos, Zhuofan Chen*, Baoxin Huang*. Long noncoding RNA and mRNA  expression profiles in peri-implantitis versus periodontitis. Journal of  periodontal research, 2019, accepted. (IF: 2.613)

22.  Rachana  Shrestha#, Xin Liu#, Shoucheng Chen, Zhipeng Li, Zetao Chen, Edmond H. N. Pow,Zhuofan Chen*,  Baoxin Huang*. Correlation of anterior overbite with root position and buccal  bone thickness of maxillary anterior teeth: a CBCT study. Surgical and  Radiologic Anatomy. 2019,41(8):935-942. (IF:1.039)

 

[参编教材与论著]

1.       主编《口腔基础研究导论》,人民卫生出版社,2020,ISBN:  978-7-117-29325-9

2.      参编英文专著'The Immune  Response to Implanted Materials and Devices', by  editor Bruna Corradetti, Springer-Verlag, 2017. ISBN: 978-3-319-45431-3. Zetao  Chen, Chengtie Wu, Yin Xiao. 'Convergence of osteoimmunology and  immunomodulation for the development and assessment of bone biomaterials.'

 

[获奖及学术荣誉]

 

1.     2019/2018中山大学光华口腔医学院本科教学优秀教师奖,二等奖

2.     AIDE - Young Australia China Alumni  of the Year Award of the ACAA and TOEFL® - 2018 Australia China  Alumni Awards, finalist.

3.     2017全国口腔生物医学学术年会优秀青年研究奖三等奖

4.     2017年IADR中国分会杰出青年学者奖比赛二等奖

5.     中华口腔医学会科研管理专委会年会2017国际口腔医学青年科学家论坛明日之星奖

 

[社会兼职]

1.    广东省青年联合会第十一届委员会委员

2.    中华口腔医学会第三届口腔生物学专业委员会委员

3.    广东省口腔医学会第三届口腔种植学专委会委员

4.     中国生物材料学会青年委员会第二届委员会委员

 

 

[联系方式]

地 址:广州市陵园西路56号中山大学光华口腔医学院·附属口腔医院(510055)

电 话:020-87330592

传 真:020-83822807

E-mail:ztchensysu@163.com