梁玉洁 | 中山大学附属口腔医院

梁玉洁

主任医师博士生导师硕士生导师

导师简介

【学位 / 学历】

博士 / 博士研究生

【学术简历】

2002.09-2007.07 中山大学口腔医学专业获学士学位

2007.09-2012.07 中山大学口腔临床医学专业获博士学位

2012.07-2015.12 中山大学附属口腔医院口腔颌面外科主治医师

2015.12-2020.12 中山大学附属口腔医院口腔颌面外科副主任医师

2020.12-至今中山大学附属口腔医院口腔颌面外科主任医师

【研究方向】

1. 口腔颌面头颈肿瘤临床、基础及应用研究

2. 侵犯颅底的口腔颌面部肿瘤综合诊疗策略

3. 新辅助治疗在晚期头颈肿瘤中的新策略探究

4. 口腔颌面组织缺损后语音吞咽障碍的机制及康复策略

【主持课题】

1. 2024年：《头颈鳞癌免疫治疗肿瘤退缩路径的关键分子研究》，广州市科技计划项目科技菁英“领航”项目，30万

2. 2020年：《中枢神经系统远程启动及调控舌鳞癌微环境程序性坏死的作用机制》，国家科学自然基金面上项目，55万

【发表论文】

1. Yu S#, Li J#, Zhang J, Zeng G, Zeng B, Song S, Lao Z, Chen H, Wen Z, Yang Z, Li X, Li K, Yang L, Liu H, Liu L, Liao G, Chen Y, Liang Y*. Nanosized Shikonin Disrupts Tumor-Cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy. ACS Nano. 2025 Apr 15;19(14):13889-13905.

2. Li J, Alaoui H, Lu H, Wang D, Liang Y*. Craniofacial Langerhans Cell Histiocytosis Successfully Treated Through Intralesional Injection of Triamcinolone Acetonide: A Retrospective Study. J Craniofac Surg. 2025 Mar 31. doi: 10.1097/SCS.0000000000011300. Epub ahead of print. PMID: 40162971.

3. Yang L#, Zhang S#, Li J#, Feng C#, Zhu L#, Li J, Lin L, Lv X, Su K, Lao X, Chen J, Cao W, Li S, Tang H, Chen X, Liang L, Shang W, Cao Z, Qiu F, Li J, Luo W, Gao S, Wang S, Zeng B, Duan W, Ji T, Liao G, Liang Y*. Diagnosis of lymph node metastasis in oral squamous cell carcinoma by an MRI-based deep learning model. Oral Oncol. 2025 Feb;161:107165.

4. Mei X#, Luo W#, Duan W, Guo Z, Lao X, Zhang S, Yang L, Zeng B, Gong J, Deng W, Liao G, Liang Y. Development and Validation of Machine Learning Models for Predicting Tumor Progression in OSCC. Oral Dis. 2025 Feb;31(2):426-434.

5. Duan W, Wu Z, Jiang H, Liao G, Liang Y, Lao X. Preoperative thromboelastography parameters in predicting the tumour stage of oral squamous cell carcinoma. BMC Cancer. 2024 Sep 11;24(1):1136.

6. Li J#, Tan J#, Wang T, Yu S, Guo G, Li K, Yang L, Zeng B, Mei X, Gao S, Lao X, Zhang S, Liao G, Liang Y. cGAS-ISG15-RAGE axis reprogram necroptotic microenvironment and promote lymphatic metastasis in head and neck cancer. Exp Hematol Oncol. 2024 Jun 26;13(1):63. doi: 10.1186/s40164-024-00531-5.

7. Li J#, Zhang S#, Ouyang D, Zeng L, Qiao Y, Deng W, Liao G, Liang Y. Favorable effects of open surgery on patients with extensive skull base osteoradionecrosis through a personalized sequential approach: A case series. J Craniomaxillofac Surg. 2024 Mar;52(3):302-309.

8. Chen J#, Tang S#, Zheng Q, Li J, Jiang H, Lu H, Liao G, Li K, Liang Y. The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma. Exp Cell Res. 2024 Mar 1;436(1):113957.

9. Wu J, Shen Y, Zeng G, Liang Y, Liao G. SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma. Cancer Gene Ther. 2024 Feb;31(2):311-321.

10. Zhang XH#, Li J#, He Z, Wang D, Liao G, Zhang SE, Duan H, Mou Y, Liang Y. Clinical application of a three-dimensional-printed model in the treatment of intracranial and extracranial communicating tumors: a pilot study. 3D Print Med. 2024 Jan 22;10(1):2.

11. Lu D, Zhou X, Sun H, Zeng B, Fu J, Gong J, Liao G, Liang Y, Yang L. Risk of second primary cancer in patients with head and neck squamous cell carcinoma: a systemic review and meta-analysis. Clin Oral Investig. 2023 Sep;27(9):4897-4910

12. Mohamed AAS#, Liang YJ#, Al-Shujaa EA, Yang L, Luo WH, Liao GQ*. Volumetric change of bony cavity and shrinkage speed after marsupialization for odontogenic keratocyst and unicystic ameloblastoma. Int J Oral Maxillofac Surg. 2023 Jun;52(6):670-678.

13. Xu J#, Liu H#, Wang T#, Wen Z, Chen H, Yang Z, Li L, Yu S, Gao S, Yang L, Li K, Li J, Li X, Liu L, Liao G, Chen Y, Liang Y. CCR7 Mediated Mimetic Dendritic Cell Vaccine Homing in Lymph Node for Head and Neck Squamous Cell Carcinoma Therapy. Adv Sci (Weinh). 2023 Jun;10(17):e2207017.

14. Gao S#, Tang Y#, Sun W, Liu Z, Zhao T, Li X, Wang T, Liao G, Xu T, Zheng G, Liang Y*. 3D-bioprinted GelMA nerve guidance conduits promoted peripheral nerve regeneration by inducing trans-differentiation of MSCs into SCLCs via PIEZO1/YAP axis. Materials Today Advances 2023;17.

15. Zeng B#, Tan J#, Guo G#, Li Z, Yang L, Lao X, Wang D, Ma J, Zhang S, Liao G, Liang Y. The oral cancer microbiome contains tumor space–specific and clinicopathology-specific bacteria. Frontiers in Cellular and Infection Microbiology 2022;12.

16. Li K#, Gong J#, Zheng Q#, Yang L, Mei X, Chen J, Liao G, Liang Y*. Preliminary study on the molecular features of mutation in multiple primary oral cancer by whole exome sequencing. Frontiers in Oncology 2022;12.

17. Huang Q#, He X#, Yang WF, Ye J, Lin Z, Xiong C, Liang YJ*. Nutritional status in patients of mandibular osteoradionecrosis: A single-institution experience. Oral Diseases 2022;28:513-520.

18. Liang YJ, Mei XY, Zeng B, Zhang SE, Yang L, Lao XM, Liao GQ. Prognostic role of preoperative D-dimer, fibrinogen and platelet levels in patients with oral squamous cell carcinoma. BMC Cancer 2021;21.

19. Saenthaveesuk P, Yang L, Zeng B, Xu M, Young S, Liao G, Liang Y*. Development and validation of multiparametric MRI-based nomogram for predicting occult metastasis risk in early tongue squamous cell carcinoma. BMC Cancer 2021;21.

20. Zheng Q#, Yang L#, Zeng B, Li J, Guo K, Liang Y, Liao G. Artificial intelligence performance in detecting tumor metastasis from medical radiology imaging: A systematic review and meta-analysis. EClinicalMedicine 2021;31

21. Xiao Y, Wang T, Deng W, Yang L, Zeng B, Lao X, Zhang S, Liu X, Ouyang D, Liao G, Liang Y. Data mining of an acoustic biomarker in tongue cancers and its clinical validation. Cancer Medicine 2021;10:3822-3835.

22. Guan C#, Ouyang D#, Qiao Y, Li K, Zheng G, Lao X, Zhang S, Liao G, Liang Y. CA9 transcriptional expression determines prognosis and tumour grade in tongue squamous cell carcinoma patients. Journal of Cellular and Molecular Medicine 2020;24:5832-5841.

23. Li J#, Huang S#, Zeng L#, Li K, Yang L, Gao S, Guan C, Zhang S, Lao X, Liao G, Liang Y. Necroptosis in head and neck squamous cell carcinoma: characterization of clinicopathological relevance and in vitro cell model. Cell Death and Disease 2020;11.

24. Liang Y#, Guan C#, Li K, Zheng G, Wang T, Zhang S, Liao G*. MMP25 Regulates Immune Infiltration Level and Survival Outcome in Head and Neck Cancer Patients. Frontiers in Oncology 2020;10.

25. Liang Y#, Xu J#, Chu M#, Mai J, Lai N, Tang W, Yang T, Zhang S, Guan C, Zhong F, Yang L, Liao G*. Neurosensory dysfunction: A diagnostic marker of early COVID-19. International Journal of Infectious Diseases 2020;98:347-352.

26. Xu J#, Chu M#, Zhong F#, Tan X, Tang G, Mai J, Lai N, Guan C, Liang Y, Liao G. Digestive symptoms of COVID-19 and expression of ACE2 in digestive tract organs. Cell Death Discovery 2020;6.

27.Guan C#, Xiao Y#, Li K, Wang T, Liang Y, Liao G. MMP-12 regulates proliferation of mouse macrophages via the ERK/P38 MAPK pathways during inflammation. Experimental Cell Research 2019;378:182-190.

28.Li K#, Yang L#, Li J#, Guan C, Zhang S, Lao X, Ouyang D, Zheng G, Gao S, Wang D, Liang Y, Liao G. TGFβ induces stemness through non-canonical AKT-FOXO3a axis in oral squamous cell carcinoma. EBioMedicine 2019;48:70-80.

29.Liu X#, Chen D#, Lao X, Liang Y. The value of MYB as a prognostic marker for adenoid cystic carcinoma: Meta-analysis. Head and Neck 2019;41:1517-1524.

【参编教材与论著】

2024年副主编《口腔癌、口咽癌——全生命周期诊疗及康复》人民卫生出版社 9787117370981

【获奖及学术荣誉】

1. 2024年国家优秀青年医师

2. 2021年广东省科技进步奖二等奖

【社会兼职】

1. 中华口腔医学会口腔颌面外科专委会常委

2. 中国康复医学会吞咽障碍康复专业委员会副主任委员

3. 中华口腔医学会口腔颌面-头颈肿瘤专委会委员

4. 中华口腔医学会口腔遗传病及罕见病专委会委员

5. 广东省抗癌协会头颈肿瘤专业委员会副主任委员

6. 广东省精准医学应用学会儿童肿瘤分会副主任委员

7. 广东省肿瘤康复学会头颈肿瘤分会副主任委员

8. 中国医疗保健国际交流促进会颅底外科分会委员会青年委员

9. 广东省研究型医院学会理事

10. 广东省健康科普促进会头颈肿瘤防治分会副主委

11. 广东省康复医学会吞咽障碍康复分会常委

12. 广东省口腔医学会口腔颌面外科专委会常委

【联系方式】

地址：广东省广州市越秀区陵园西路56号中山大学附属口腔医院

电话：020-83846030

邮箱：liangyj35@mail.sysu.edu.cn

【研究方向】

1. 口腔颌面头颈肿瘤临床、基础及应用研究

2. 侵犯颅底的口腔颌面部肿瘤综合诊疗策略

3. 新辅助治疗在晚期头颈肿瘤中的新策略探究

4. 口腔颌面组织缺损后语音吞咽障碍的机制及康复策略

【主持课题】

【发表论文】

2. Li J, Alaoui H, Lu H, Wang D, Liang Y*. Craniofacial Langerhans Cell Histiocytosis Successfully Treated Through Intralesional Injection of Triamcinolone Acetonide: A Retrospective Study. J Craniofac Surg. 2025 Mar 31. doi: 10.1097/SCS.0000000000011300. Epub ahead of print. PMID: 40162971.

4. Mei X#, Luo W#, Duan W, Guo Z, Lao X, Zhang S, Yang L, Zeng B, Gong J, Deng W, Liao G*, Liang Y*. Development and Validation of Machine Learning Models for Predicting Tumor Progression in OSCC. Oral Dis. 2025 Feb;31(2):426-434.

5. Duan W, Wu Z, Jiang H, Liao G, Liang Y*, Lao X*. Preoperative thromboelastography parameters in predicting the tumour stage of oral squamous cell carcinoma. BMC Cancer. 2024 Sep 11;24(1):1136.

7. Li J#, Zhang S#, Ouyang D, Zeng L, Qiao Y, Deng W, Liao G*, Liang Y*. Favorable effects of open surgery on patients with extensive skull base osteoradionecrosis through a personalized sequential approach: A case series. J Craniomaxillofac Surg. 2024 Mar;52(3):302-309.

8. Chen J#, Tang S#, Zheng Q, Li J, Jiang H, Lu H, Liao G, Li K*, Liang Y*. The competitive mechanism of EZH1 and EZH2 in promoting oral squamous cell carcinoma. Exp Cell Res. 2024 Mar 1;436(1):113957.

9. Wu J, Shen Y, Zeng G, Liang Y*, Liao G*. SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma. Cancer Gene Ther. 2024 Feb;31(2):311-321.

10. Zhang XH#, Li J#, He Z, Wang D, Liao G, Zhang SE, Duan H, Mou Y*, Liang Y*. Clinical application of a three-dimensional-printed model in the treatment of intracranial and extracranial communicating tumors: a pilot study. 3D Print Med. 2024 Jan 22;10(1):2.

11. Lu D, Zhou X, Sun H, Zeng B, Fu J, Gong J, Liao G, Liang Y*, Yang L*. Risk of second primary cancer in patients with head and neck squamous cell carcinoma: a systemic review and meta-analysis. Clin Oral Investig. 2023 Sep;27(9):4897-4910

12. Mohamed AAS#, Liang YJ#, Al-Shujaa EA, Yang L, Luo WH, Liao GQ*. Volumetric change of bony cavity and shrinkage speed after marsupialization for odontogenic keratocyst and unicystic ameloblastoma. Int J Oral Maxillofac Surg. 2023 Jun;52(6):670-678.

13. Xu J#, Liu H#*, Wang T#, Wen Z, Chen H, Yang Z, Li L, Yu S, Gao S, Yang L, Li K, Li J, Li X, Liu L, Liao G*, Chen Y*, Liang Y*. CCR7 Mediated Mimetic Dendritic Cell Vaccine Homing in Lymph Node for Head and Neck Squamous Cell Carcinoma Therapy. Adv Sci (Weinh). 2023 Jun;10(17):e2207017.

14. Gao S#, Tang Y#, Sun W, Liu Z, Zhao T, Li X, Wang T, Liao G, Xu T*, Zheng G*, Liang Y*. 3D-bioprinted GelMA nerve guidance conduits promoted peripheral nerve regeneration by inducing trans-differentiation of MSCs into SCLCs via PIEZO1/YAP axis. Materials Today Advances 2023;17.

15. Zeng B#, Tan J#, Guo G#, Li Z, Yang L, Lao X, Wang D, Ma J, Zhang S, Liao G*, Liang Y*. The oral cancer microbiome contains tumor space–specific and clinicopathology-specific bacteria. Frontiers in Cellular and Infection Microbiology 2022;12.