【学位 / 学历】

博士 / 博士研究生

【学术简历】

1991.09-1996.07  武汉大学口腔医学专业获本科学位

1998.09-2001.06  中山大学牙体牙髓病学专业获硕士学位

2006.01-2009.12  新加坡国立大学口腔医学专业获博士学位

【研究方向】

1.牙髓及根尖周病的病因与防治

2.医理工相结合探索口腔生物材料在组织再生中的作用机制

3. 细胞外囊泡在血管生成及骨再生中的作用机制

【主持课题】

1. 2018.01-2022.01：《粪肠球菌定植牙本质的特异性和非特异性黏附力机制研究》，国家自然科学基金面上项目，58万

2. 2022.01-2024.12：《DPSC源性外泌体蛋白FGD5激活Cdc42/p38 MAPK通路促进皮肤伤口愈合的作用机制研究》，广东省自然科学基金面上项目，10万

3. 2024.01-2026.12：《可注射水凝胶递释增强型外泌体靶向Smurf2激活TGF-β1/Smad2信号通路促进伤口愈合的作用机制研究》，广东省自然科学基金面上项目，15万

【发表论文】

1. Huang L, Zhang X, Shao J, Zhou Z, Chen Y, Hu X*. Nanoscale chemical and mechanical heterogeneity of human dentin characterized by AFM-IR and bimodal AFM. J Adv Res. 2020；22:163-171.

2. Lin D, Zhou Z, Zhang M, Yao S, Yuan L, Xu M, Zhang X, Hu X*.Electrical stimulations generated by P(VDF-TrFE) films enhance adhesion forces and odontogenic differentiation of dental pulp stem cells (DPSCs). ACS Appl Mater Interfaces. 2024;16(22):28029-28040.

3. Hu X*, Zhong Y, Kong Y, Chen Y, Feng J, Zheng J*. Lineage-specific exosomes promote the odontogenic differentiation of human dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of microRNAs. Stem Cell Res Ther. 2019;10(1):170.

4. Lei L, Huang Z, Feng J, Huang Z, Tao Y, Hu X*, Zhang X*. Loss of receptor tyrosine kinase-like orphan receptor 2 impairs the osteogenesis of mBMSCs by inhibiting signal transducer and activator of transcription 3. Stem Cell Res Ther. 2020;11(1):137.

5. Zhou Z, Zheng J, Lin D, Xu R, Chen Y, Hu X*. Exosomes derived from dental pulp stem cells accelerate cutaneous wound healing by enhancing angiogenesis via the Cdc42/p38 MAPK pathway. Int J Mol Med. 2022;50(6):143.

6. Yuan L, Liu Y, Lv K, Zhang M, Hu X*. Effects of poly(amidoamine) as an extrafibrillar demineralization agent on dentin bonding durability of deciduous teeth. J Dent. 2025;154:105609.

7. Wang X, Wang S, Yuan L, Liang ZH, Zhang XY, Lin DL, Hu X*. Influence of adhesion force on croRS gene expression and antibiotic resistance of Enterococcus faecalis. J Biomed Mater Res A. 2024;112(1):44-52.

8. Xu R, Zhou Z, Lin D, Yuan L, Wang S, Xu M, Chen Y, Hu X*. Enhancing effects of immobilized chondroitin sulfate on odontogenic differentiation of dental pulp stem cells and reparative dentin formation. J Endod. 2023;49(7):852-860.

9. Tao YW, Xing Q, Li D, Quan J, Gao Y, Hu X*, Zhang X*. Association between increased inducible costimulator/inducible costimulator ligand expression with bone destruction in apical periodontitis. J Endod. 2019;45(7):890-897.

10. Lu JR, Xu RM, Chen YN, Chan LT, Feng X, Lin LCH, Yao YCH, Hu X*, Zhang XL*. Injectable Col-I/CS hydrogel enhances bone regeneration in mice tibial mono-cortical defect with impaired osteogenesis. Mater Today Commun, 2022; 32: 104070.

11. Jiang J, Zhang N, Song H, Yang Y, Li J, Hu X*. Oridonin alleviates the inhibitory effect of lipopolysaccharide on the proliferation and osteogenic potential of periodontal ligament stem cells by inhibiting endoplasmic reticulum stress and NF-κB/NLRP3 inflammasome signaling. BMC Oral Health. 2023;23(1):137.

12. Chen Y, Zheng J, Li D, Huang Z, Huang Z, Wang X, Zhang X, Hu X*. Three-dimensional position of mandibular third molars and its association with distal caries in mandibular second molars: a cone beam computed tomographic study. Clin Oral Investig. 2020;24(9):3265-3273.

【参编教材与论著】

1. 2021年 参编《牙体牙髓病病例精解》 科学技术文献出版社 9787518961115

2. 2024年 参编《牙体牙髓病多学科诊疗病例精粹》 人民卫生出版社 9787117359917

  3. 2023年 主译《口腔激光治疗新视界》 辽宁科学技术出版社 9787559126986

【获奖及学术荣誉】

2019年 广东省杰出医学青年人才

【社会兼职】

广东省口腔医学会牙体牙髓病学专业委员会常务委员

【联系方式】

地址：广州市珠江新城华夏路49号津滨腾越大厦二楼

电话：020-38092041

邮箱：huxiaol3@mail.sysu.edu.cn