郑健茂 | 中山大学附属口腔医院

郑健茂

副主任医师硕士生导师

导师简介

【学位/学历】

口腔临床医学博士

【学术简历】（注：时间正序写，从大学开始）

示例：

2006.08-2013.06 中山大学口腔医学专业获硕士学位

2013.08-2016.06 中山大学口腔临床医学专业获博士学位

2016.07-2019.12 中山大学附属口腔医院医师、主治医师

2019.12至今中山大学附属口腔医院副主任医师

【研究方向】

1.牙髓干细胞

2.牙髓再生

3.牙髓炎

【主持课题】

1. 2018/01-2020/12，81700950，MagT1激活Hspa12a/MAPK信号通路诱导BMMSCs成牙本质向分化的作用机制研究，国家自然科学基金青年项目，20万元。

2. 2022/01-2024/12, 2022A1515011266, 外泌体miR-758-3p靶向调控PTEN/PI3K/Akt通路调控巨噬细胞M2极化促进SHED成牙本质向分化, 广东省自然科学基金面上项目, 10万元。

3. 2022-07 至 2024-06, A2022322, 外泌体miR-200c-3p靶向调控PTEN/PI3K/Akt通路调控巨噬细胞M2极化促进SHED成牙本质向分化, 广东省医学科研基金项目, 0.5万元。

4. 2019/10-2022/09，2019A1515011289，外泌体miR-27a-5p靶向调控LTBP1/TGF-β1通路促进DPSC成牙本质向分化的机制研究，广东省自然科学基金面上项目，10万元。

5. 2017/01-2019/12，17ykpy74，MagTl介导Hspa12a激活MAPK信号通路诱导骨髓间充质干细胞成牙本质向分化的机制研究，中山大学青年教师培育项目，15万元。

【发表论文】

（格式：1.全部作者，论文题目，发表杂志，年卷页（作者要求：本人加粗、共一的加#、共同通讯的加*））

（1）Yueqi Chen, Jianmao Zheng#, Yizhou Chen, Haiyi Zhang, Jiayi Li, Huan Deng, Yuanyuan Kong. Average and Heterogeneous Associations between Secondhand Smoking and Tooth Loss. Journal of Dental Research. 2026;0(0).

（2）Jiyuan Zuo, Qining Guo, Youzhun Fan, Xiaobin Fu, Fengyuan Zhang, Xiaojing Zhu, Chengyun Ning, Yuanyuan Kong, Peng Yu, Jianmao Zheng, Self-powered intracellular nanogenerator attenuates inflammatory osteolysis through mitochondrial MRS2/Mg2+-mediated macrophage repolarization and osteoclastogenesis inhibition,Materials Today Bio,Volume 33,2025,102050

（3）Jianmao Zheng, Jiyuan Zuo, Cairong Xiao, Qining Guo, Xiaobin Fu, Chengyun Ning, Peng Yu*, Wireless electrical stimulation generated by piezoelectric nanomaterial promotes the dental pulp regeneration via regulating mitochondrial Ca2+/PKA signaling pathway，journal of material science & technology, 2024, 168:24-34

（4）Yueqi Chen , Jianmao Zheng#, Haiyi Zhang, Shaopeng Chen , Linyuan Yu, Yuanyuan Kong. Passive smoking is associated with poor carious status in adults: A population-based cross-sectional study. Journal of Dentistry. 2026,165:106306.

（5）Jiyuan Zuo, Qining Guo, Xiaobin Fu, Zhishan Li, Fengyuan Zhang, Jianmao Zheng,Stem cells of human exfoliated deciduous teeth -delivered miR-200c-3p contained in small extracellular vesicles regulates M2 macrophage polarization via PTEN/PI3K/Akt pathway in vitro, Biochemical and Biophysical Research Communications,Volume 777,2025,152259

(6) Ziyu Zhou; Jianmao Zheng*; Danle Lin; Ruoman Xu; Yanan Chen; Xiaoli Hu ; Exosomes derived from dental pulp stem cells accelerate cutaneous wound healing by enhancing angiogenesis via the Cdc42/p38 MAPK pathway, International Journal of Molecular Medicine, 2022, 50(6): 143

(7) Jianmao Zheng; Yuanyuan Kong; Xiaoli Hu; Zhishan Li; Yaoyin Li1;Yingqun Zhong; Xi Wei; Junqi Ling; MicroRNA-enriched small extracellular vesicles possess odonto-immunomodulatory properties for modulating the immune response of macrophages and promoting odontogenesis., Stem Cell Research & Therapy, 2020, 11(1): 517.

(8) Jianmao Zheng, YuanYuan Kong, YaoYin Li, Wen Zhang. MagT1 regulated the odontogenic differentiation of BMMSCs induced byTGC-CM via ERK signaling pathway. Stem Cell Res Ther. 2019;10(1):48.

(9) Yuanyuan Kong; Xiaoli Hu; Yingqun Zhong; Ke Xu; Buling Wu*; Jianmao Zheng*; Magnesium-enriched microenvironment promotes odontogenic differentiation in human dental pulp stem cells by activating ERK/BMP2/Smads signaling, Stem Cell Research & Therapy, 2019, 10(1): 378.

(10) Xiaoli Hu, Yingqun Zhong, YuanYuan Kong, Yanan Chen, Junming Feng, Jianmao Zheng. Lineage-specific exosomes promote the odontogenic differentiation of dental pulp stem cells (DPSCs) through TGFβ1/smads signaling pathway via transfer of mircoRNAs. Stem Cell Res Ther.2019;10:170.

(11) Haozhen Ma, Jianmao Zheng*, Xiaolan Li，Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population，Int J Med Sci. 2020 Sep 12;17(16):2531-2543.

(12) Yanan Chen，Jianmao Zheng#，Danna Li，Zhuwei Huang，Zijing Huang，Xue Wang，Xiaolei Zhang，Xiaoli Hu，Three-dimensional position of mandibular third molars and its association with distal caries in mandibular second molars: a cone beam computed tomographic study，Clinical Oral Investigations (2020) 24:3265–3273.

（13）Jianmao Zheng; Xueli Mao; Junqi Ling*; Chanchan Chen; Wen Zhang; Role of Magnesium Transporter Subtype 1 (MagT1) in the Osteogenic Differentiation of Rat Bone Marrow Stem Cells，Biol Trace Elem Res，2016，171（1）：131~137

（14）Kong YY#, Zheng JM#, Zhang WJ, Jiang QZ*, Yang XC, Yu M, Zeng SJ, The relationship between vitamin D receptor gene polymorphism and deciduous tooth decay in Chinese children，BMC Oral Health，2017，17(1):111.

（15）Jianmao Zheng, Xueli Mao, Junqi Ling*, Qun He, Jingjing Quan, Hongbo Jiang, Association between serum level of magnesium and postmenopausal osteoporosis: a meta-analysis, Biol Trace Elem Res. 2014,159(1-3):8-14.

（16）Jianmao Zheng, Xueli Mao, Junqi Ling*, Qun He, Jingjing Quan, Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis, Biol Trace Elem Res, 2014,160(1):15-23.

（17）郑健茂,毛学理,凌均棨. 镁基支架及其在动物骨缺损修复中的应用[J].国际口腔医学杂志,2015,42(06):720-723.