陶小安 | 中山大学附属口腔医院

陶小安

主任医师博士生导师硕士生导师

导师简介

【学位 / 学历】

博士 / 博士研究生

【学术简历】

1997.09-2002.06 江西医学院（南昌大学）口腔医学专业获学士学位

2002.09-2005.06 中山大学口腔临床医学专业获硕士学位

2005.09-2008.07 中山大学口腔临床医学专业获博士学位

2015.09-2016.08 美国安德森癌症中心访问学者

【研究方向】

口腔黏膜疾病免疫/代谢病理机制

【主持课题】

1. 2024年：《自体荧光引导下的口腔白斑光动力精准治疗》，广州地区临床高新和重大技术项目，40万

2. 2022年：《谷氨酰胺代谢通过IL-37调控口腔黏膜免疫稳态的机制研究》，国家自然科学基金面上项目，52万

3. 2021 年：《谷氨酰胺代谢调控口腔黏膜上皮细胞自噬/凋亡平衡的机制研究》，广东省自然科学基金面上项目，10万

【发表论文】

1. He H#, Lv C#, Xie Y#, Li W, Ling Z, Cheng B, Tao X. Carnosine alleviates oxidative stress to prevent cellular senescence by regulating Nrf2/HO-1 pathway: a promising anti-aging strategy for oral mucosa. Front. Pharmacol. 2025, 16:1559584. doi: 10.3389/fphar.2025.1559584

2. Mu W#, Li S#, Lu Q, Wang J, Tao X. The immediate pain relief of low-level laser therapy for burning mouth syndrome: a retrospective study of 94 cases. Front Oral Health. 2024 Dec 18;5:1458329. doi: 10.3389/froh.2024.1458329

3. Li W#, Zeng Q#, Wang B#, Lv C, He H, Yang X, Cheng B, Tao X*. Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization. Redox Biol. 2024 Oct:76:103335

4. Su Z#, Lu J#, Ling Z, Li W, Yang X, Cheng B, Tao X*. Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus. Biochem Pharmacol. 2023 Sep 8:115796. doi: 10.1016/j.bcp.2023.115796. Online ahead of print.

5. Li W#, Ling Z#, Wang J, Su Z, Lu J, Yang X, Cheng B, Tao X*. ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus. Biochem Pharmacol. 2023 Aug 25:115767. doi: 10.1016/j.bcp.2023.115767. Online ahead of print.

6. Guan J#, Xu X#, Qiu G#, He C, Lu X, Wang K, Liu X, Li Y, Ling Z, Tang X, Liang Y, Tao X, Cheng B, Yang B*. Cellular hierarchy framework based on single-cell/multi-patient sample sequencing reveals metabolic biomarker PYGL as a therapeutic target for HNSCC. J Exp Clin Cancer Res. 2023 Jul 8;42(1):162.

7. Lu J#, Su Z#, Li W, Ling Z, Cheng B, Yang X, Tao X*. ASCT2-mediated glutamine uptake of epithelial cells facilitates CCL5-induced T cell infiltration via ROS-STAT3 pathway in oral lichen planus. Int Immunopharmacol. 2023 Apr 26;119:110216. doi: 10.1016/j.intimp.2023.110216. Online ahead of print.

8. Hu J#, Ling Z#, Li W, Su Z, Lu J, Zeng Q, Cheng B, Tao X. Glutamine promotes the proliferation of epithelial cells via mTOR/S6 pathway in oral lichen planus. J Oral Pathol Med. 2023 Feb;52(2):150-160.

9. Zihang Ling# , Wei Li # , Jiaqi Hu #, Yuanyuan Li , Miao Deng , Siyuan Zhang, Xianyue Ren, Tong Wu , Juan Xia, Bin Cheng, Xiaoan Tao*. Targeting CCL2-CCR4 axis suppress cell migration of head and neck squamous cell carcinoma. Cell Death Dis, 2022 Feb 17;13(2):158. doi: 10.1038/s41419-022-04610-5.

10. Su Z#, Tao X*. Current Understanding of IL-37 in Human Health and Disease. Front Immunol. 2021 Jun 25;12:696605. doi: 10.3389/fimmu.2021.696605.

11. Su Z#, Hu J#, Cheng B, Tao X*. Efficacy and safety of topical administration of tacrolimus in oral lichen planus: An updated systematic review and meta-analysis of randomized controlled trials. J Oral Pathol Med. 2022 Jan;51(1):63-73. doi: 10.1111/jop.13217.

12. Ling Z, Cheng B, Tao X*. Epithelial-to-mesenchymal transition in oral squamous cell carcinoma: Challenges and opportunities. Int J Cancer. 2021 Apr 1;148(7):1548-1561. doi: 10.1002/ijc.33352.

13. Xi Yang#, Xiaoan Tao#, Weijuan Qi, Zhao Liu, Yamin Wang, Qianqian Han, Chenrong Xu. TLR-4 targeting contributes to the recovery of osteoimmunology in periodontitis. J Periodontal Res. 2021 Aug;56(4):782-788. doi: 10.1111/jre.12877

14. Luo Y#, Li W#, Ling Z, Hu Q, Fan Z, Cheng B, Tao X. ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine-addicted OSCC cells. Cancer Med. 2020, 9(10):3489-3499.

【参编教材与论著】

1. 2024年11月参编《口腔癌、口咽癌:全生命周期诊疗及康复》人民卫生出版社 9787117370981

2. 2022年4月参编《口腔黏膜病标准数据集》科学出版社 9787030716989

【获奖及学术荣誉】

1. 2022年分子标志物与口腔黏膜潜在恶性疾患的演变及诊疗，广东省科技进步奖，二等奖，第三完成人

2. 2023年广东省医院优秀临床科主任

【社会兼职】

1. 广东省口腔医学会口腔黏膜病专委会副主任委员

2. 中华口腔医学会中西医结合专委会委员

【联系方式】

地址：广州市陵园西路56号

电话：020-83741891

邮箱：taoxiaoa@mail.sysu.edu.cn

【研究方向】

口腔黏膜疾病免疫/代谢病理机制

【主持课题】

【发表论文】

1. He H#, Lv C#, Xie Y#, Li W, Ling Z, Cheng B*, Tao X*. Carnosine alleviates oxidative stress to prevent cellular senescence by regulating Nrf2/HO-1 pathway: a promising anti-aging strategy for oral mucosa. Front. Pharmacol. 2025, 16:1559584. doi: 10.3389/fphar.2025.1559584

2. Mu W#, Li S#, Lu Q, Wang J*, Tao X*. The immediate pain relief of low-level laser therapy for burning mouth syndrome: a retrospective study of 94 cases. Front Oral Health. 2024 Dec 18;5:1458329. doi: 10.3389/froh.2024.1458329

3. Li W#, Zeng Q#, Wang B#, Lv C, He H, Yang X*, Cheng B*, Tao X*. Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization. Redox Biol. 2024 Oct:76:103335

4. Su Z#, Lu J#, Ling Z, Li W, Yang X*, Cheng B*, Tao X*. Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus. Biochem Pharmacol. 2023 Sep 8:115796. doi: 10.1016/j.bcp.2023.115796. Online ahead of print.

5. Li W#, Ling Z#, Wang J, Su Z, Lu J, Yang X*, Cheng B*, Tao X*. ASCT2-mediated glutamine uptake promotes Th1 differentiation via ROS-EGR1-PAC1 pathway in oral lichen planus. Biochem Pharmacol. 2023 Aug 25:115767. doi: 10.1016/j.bcp.2023.115767. Online ahead of print.

8. Hu J#, Ling Z#, Li W, Su Z, Lu J, Zeng Q, Cheng B*, Tao X*. Glutamine promotes the proliferation of epithelial cells via mTOR/S6 pathway in oral lichen planus. J Oral Pathol Med. 2023 Feb;52(2):150-160.